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Noise measurements in bilayer lipid membranes during electroporation
journal contribution
posted on 2023-06-08, 18:27 authored by A Ridi, Enrico Scalas, A GliozziA study of voltage fluctuations in bilayer lipid membranes during electroporation and under current-clamp conditions is presented. Qualitative considerations based on the electroporation theory are used in order to explain the phenomenon on long time scale. Indeed, the current-clamp condition induces a feedback mechanism on the pore formation and therefore on the macroscopic conductance. Voltage fluctuations can thus be recorded. These fluctuations are nonstationary long-living and have a flicker power spectrum over nearly four decades of frequency between about 10-2 and 102Hz. The study of the fluctuations in the time domain has been performed by introducing an electrical model of the system formed by the membrane and the circuit under current-clamp configuration. The analysis of the time series gives a characteristic time of 100ms for the circuitry response to the fragments of electroporation signals with characteristic times faster than 100ms. During electroporation, the response to an external periodic stimulus in the frequency range 10-1-10Hz shows that the system behaves linearly, even if voltage fluctuations are present.
History
Publication status
- Published
Journal
The European physical journal. E, Soft matterISSN
1292-8941Publisher
Springer VerlagExternal DOI
Issue
2Volume
2Page range
161-168Department affiliated with
- Mathematics Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-10-02Usage metrics
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