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Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy
journal contribution
posted on 2023-06-08, 17:09 authored by Maeve K Lalor, Anne Ben-Smith, Patricia Gorak-Stolinska, Rosemary E Weir, Sian Floyd, Rose Blitz, Hazzie Mvula, Melanie NewportMelanie Newport, Keith Branson, Nuala McGrath, Amelia C Crampin, Paul E M Fine, Hazel M DockrellBacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-gamma response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.
History
Publication status
- Published
Journal
Journal of Infectious DiseasesISSN
0022-1899Publisher
Oxford University PressExternal DOI
Issue
6Volume
199Page range
795-800Department affiliated with
- Global Health and Infection Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-05-12Usage metrics
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