University of Sussex
Browse

File(s) not publicly available

Non-uptake of highly active antiretroviral therapy among patients with a CD4 count

journal contribution
posted on 2023-06-08, 16:22 authored by C Kober, M Johnson, M Fisher, T Hill, J Anderson, L Bansi, M Gompels, A Palfreeman, D Dunn, B Gazzard, R Gilson, F Post, A N Phillips, J Walsh, C Orkin, V Delpech, J Ainsworth, C Leen, C A Sabin, The UK Collaborative HIV Cohort (CHIC) Study
OBJECTIVES Current British HIV Association (BHIVA) guidelines recommend that all patients with a CD4 count <350 cells/µL are offered highly active antiretroviral therapy (HAART). We identified risk factors for delayed initiation of HAART following a CD4 count <350 cells/µL. METHODS All adults under follow-up in 2008 who had a first confirmed CD4 count <350 cells/µL from 2004 to 2008, who had not initiated treatment and who had >6 months of follow-up were included in the study. Characteristics at the time of the low CD4 cell count and over follow-up were compared to identify factors associated with delayed HAART uptake. Analyses used proportional hazards regression with fixed (sex/risk group, age, ethnicity, AIDS, baseline CD4 cell count and calendar year) and time-updated (frequency of CD4 cell count measurement, proportion of CD4 counts <350 cells/µL, latest CD4 cell count, CD4 percentage and viral load) covariates. RESULTS Of 4871 patients with a confirmed low CD4 cell count, 436 (8.9%) remained untreated. In multivariable analyses, those starting HAART were older [adjusted relative hazard (aRH)/10 ?years 1.15], were more likely to be female heterosexual (aRH 1.13), were more likely to have had AIDS (aRH 1.14), had a greater number of CD4 measurements

History

Publication status

  • Published

Journal

HIV Medicine

ISSN

1464-2662

Publisher

Wiley

Issue

1

Volume

13

Page range

73-78

Department affiliated with

  • BSMS Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-12-13

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC