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Tissue-protective cytokines: structure and evolution

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posted on 2023-06-08, 14:49 authored by Pietro Ghezzi, Darrell Conklin
Cytokines are important mediators of host defense and immunity, and were first identified for their role in immunity to infections. It was then found that some of them are pathogenic mediators in inflammatory diseases and much of the emphasis is now on pro-inflammatory cytokines, also in consideration of the fact that TNF inhibitors became effective drugs in chronic inflammatory diseases. The recent studies on the tissue-protective activities of erythropoietin (EPO) led to the term "tissue-protective cytokine." We discuss here how tissue-protective actions might be common to other cytokines, particularly those of the 4-alpha helical structural superfamily.

History

Publication status

  • Published

Journal

Methods in molecular biology (Clifton, N.J.)

ISSN

1940-6029

Publisher

Humana Press

Issue

982

Volume

982

Page range

43-58

Book title

Tissue-protective cytokines: methods and protocols

Series

Methods in molecular biology

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Editors

Anthony Cermi, Pietro Ghezzi

Legacy Posted Date

2013-04-30

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