File(s) not publicly available
Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease
journal contribution
posted on 2023-06-08, 13:46 authored by Amir Ali Rahsepar, Hossein Pourghadamyari, Mohsen Moohebati, Seyyed Mohammad Reza Parizadeh, Shima Tavallaie, Roghayeh Paydar, Homa Falsoleiman, Mashalla Dehghani, Afsoon Fazlinezhad, Maral Amini, Fatemeh Khorashadizadeh, Majid Ghayour-Mobarhan, Gordon FernsGordon FernsOBJECTIVE We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects. DESIGN AND METHODS Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD). RESULTS The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>0.05). CONCLUSIONS In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.
History
Publication status
- Published
Journal
Clinical BiochemistryISSN
0009-9120Publisher
ElsevierIssue
16Volume
44Page range
1304-1308Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-19Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC