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Target detection by opponent coding in monkey prefrontal cortex

journal contribution
posted on 2023-06-08, 13:39 authored by Makoto Kusunoki, Natasha SigalaNatasha Sigala, Hamed Nili, David Gaffan, John Duncan
The pFC plays a key role in flexible, context-specific decision making. One proposal [Machens, C. K., Romo, R., & Brody, C. D. Flexible control of mutual inhibition: A neural model of two-interval discrimination. Science, 307, 1121-1124, 2005] is that prefrontal cells may be dynamically organized into opponent coding circuits, with competitive groups of cells coding opposite behavioral decisions. Here, we show evidence for extensive, temporally evolving opponent organization in the monkey pFC during a cued target detection task. More than a half of all randomly selected cells discriminated stimulus category in this task. The largest set showed target-positive activity, with the strongest responses to the current target, intermediate activity for a nontarget that was a target on other trials, and lowest activity for nontargets never associated with the target category. Second most frequent was a reverse, antitarget pattern. In the ventrolateral frontal cortex, opponent organization was strongly established in phasic responses at stimulus onset; later, such activity was widely spread across dorsolateral and ventrolateral sites. Task-specific organization into opponent cell groups may be a general feature of prefrontal decision making

History

Publication status

  • Published

Journal

Journal of Cognitive Neuroscience

ISSN

0898-929X

Publisher

Cambridge Center for Behavioral Studies

Issue

4

Volume

22

Page range

751-60

Department affiliated with

  • Clinical and Experimental Medicine Publications

Notes

Accession Number: BCI:BCI201100735852 as shown on Web of Knowledge pages. Miscellaneous Descriptors: decision making, target detection, central fixation point, stimulus category, behavioral decision, task-specific information, opponent coding, intermediate activity, anti-target pattern, dorsolateral site, ventrolateral site

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-14

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