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Pegfilgrastim in children with severe congenital neutropenia

journal contribution
posted on 2023-06-08, 13:26 authored by Francesca Fioredda, Michaela Calvillo, Marina Lanciotti, Tiziana Lanza, Laura Giunti, Elio Castagnola, Ines Lorenzi, Rossella Tonelli, Pietro Ghezzi, Carlo Dufour
Two pediatric patients affected by severe congenital neutropenia (SCN) were treated with 100 mcg/L/dose every 9-12 days within a pilot study (Observatory of the Italian Ministry of Health, Eudract Code 2005-003096-20) on the use of pegfilgrastim in patients with chronic neutropenia. Both children increased their absolute neutrophil count, reduced their infectious load, and improved their quality of life. Serum concentrations of G-CSF observed in pegfilgrastim mirrored those seen in filgrastim. These data suggest that pegfilgrastim may be beneficial in SCN patients with an exposure of hematopoietic cells to G-CSF similar to that on filgrastim.

History

Publication status

  • Published

Journal

Pediatric Blood and Cancer

ISSN

1545-5017

Publisher

Wiley-Blackwell

Issue

3

Volume

54

Page range

465-467

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-02

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