Long-term follow-up of antiretroviral-naïve HIV-positive patients treated with nevirapine

Sabin, Caroline A, Fisher, Martin, Churchill, Duncan, Pozniak, Anton, Hay, Phillip, Easterbrook, Philippa and Williams, Ian (2001) Long-term follow-up of antiretroviral-naïve HIV-positive patients treated with nevirapine. Journal of the Acquired Immune Deficiency Syndromes, 26 (5). pp. 462-5. ISSN 0894-9255

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Abstract

This article reports on the extended follow-up of 125 antiretroviral (ARV)-naive patients treated with nevirapine (NVP) in the United Kingdom. The patients have been observed for a median of 1.8 years after starting NVP (range, 4 days-2.7 years). Baseline CD4 counts and HIV RNA levels were 210 (interquartile range, 130 - 335) cells/mm3 and 4.86 (range, 4.52-5.26) log10 copies/ml, respectively. Eleven patients (9.0%) developed a rash thought to be related to NVP, of whom 4 permanently discontinued NVP. Twenty-four months after starting NVP, RNA levels had dropped by a median of 2.32 log10 copies/ml and CD4 counts increased by a median of 143 cells/mm3. In all, 96 patients had at least one viral load measured <500 copies/ml, a median of 2.8 months after starting NVP. RNA levels rebounded >500 copies/ml in 37 of these patients, on average 2 years after initial response. In conclusion, in ARV-naive patients, NVP is generally well tolerated and long-term response rates are good.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
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Depositing User: EPrints Services
Date Deposited: 21 Feb 2012 10:03
Last Modified: 10 Jan 2020 09:22
URI: http://sro.sussex.ac.uk/id/eprint/37869
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