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Determining the identity of the cochlear amplifier: electrical stimulation of the tecta mouse cochlea

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posted on 2023-06-08, 07:40 authored by Drexl, Mellado Lagarde, Lukashkina, Lukashkin, Russell
The sensitivity, large dynamic range and narrow frequency tuning of the mammalian cochlea is determined by the passive mechanical properties of the basilar membrane (BM) and active feedback from the outer hair cells (OHCs). Two mechanisms have been proposed to provide amplification: Hair bundle motility, and OHC somatic-motility. Acoustically- and electrically-elicited mechanical responses were measured from the BMs of the cochleae of wild type and genetically modified mice where the hair bundles are freestanding and cannot react against the tectorial membrane (TM) to contribute to amplification. We found the electrically elicited responses in mutant mice, where only somatic motility can provide amplification, to be remarkably similar to acoustical and electrical responses in the wild type animals. We, therefore, conclude that somatic, not stereocilia motility is the basis of the cochlear amplifier.

History

Publication status

  • Published

Publisher

WORLD SCIENTIFIC PUBL CO PTE LTD

Pages

7.0

Presentation Type

  • paper

Event name

10th International Workshop on the Mechanics of Hearing Keele Univ, Staffordshire, ENGLAND, JUL 27-31, 2008

Event location

Keele Univ, Staffordshire, ENGLAND

Event type

conference

ISBN

978-981-283-377-8

Department affiliated with

  • Biology and Environmental Science Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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