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Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity
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posted on 2023-06-08, 07:29 authored by Emma J Cannell, Paul J Farrell, Alison SinclairThe exposure of Epstein-Barr virus immortalised B cells (LCLs) to the genotoxic effects of gamma irradiation causes a decreased proliferation of the cells. The early events in this process have been investigated here. The induction of p53 expression correlates with a cell cycle arrest in the G1 and G2/M phases of the cell cycle within 24 h of exposure, The molecular mechanism governing the decreased proliferation appears to involve the induction of the cyclin dependent kinase (cdk) inhibitor p21(CIP1) and its functional association with cdk2, (C) 1998 Federation of European Biochemical Societies.
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Publication status
- Published
Journal
FEBS LettersISSN
0014-5793Publisher
ElsevierExternal DOI
Issue
3Volume
439Page range
297-301Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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