University of Sussex
Browse

File(s) not publicly available

Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity

journal contribution
posted on 2023-06-08, 07:29 authored by Emma J Cannell, Paul J Farrell, Alison Sinclair
The exposure of Epstein-Barr virus immortalised B cells (LCLs) to the genotoxic effects of gamma irradiation causes a decreased proliferation of the cells. The early events in this process have been investigated here. The induction of p53 expression correlates with a cell cycle arrest in the G1 and G2/M phases of the cell cycle within 24 h of exposure, The molecular mechanism governing the decreased proliferation appears to involve the induction of the cyclin dependent kinase (cdk) inhibitor p21(CIP1) and its functional association with cdk2, (C) 1998 Federation of European Biochemical Societies.

History

Publication status

  • Published

Journal

FEBS Letters

ISSN

0014-5793

Publisher

Elsevier

Issue

3

Volume

439

Page range

297-301

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC