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Sequence variation in the phd gene of nonencapsulated Haemophilus influenzae isolated from patients with chronic bronchitis
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posted on 2023-06-08, 07:09 authored by Birgitta Duim, Paula Ruiter, Lucas D Bowler, Jakob Dankert, Loek van AlphenThe molecular diversity of protein D of nonencapsulated Haemophilus influenzae strains isolated from persistently infected patients with chronic bronchitis was studied by sequencing the hpd gene of four independently obtained isolates. The nucleotide (nt) sequences of the hpd genes of two strains were identical. The other two hpd sequences showed nt substitutions which were mostly synonymous. As a consequence the deduced amino acid (aa) sequences differed from the consensus sequence only by a few aa. No changes in the hpd genes were observed among the four variants of the four strains persisting in chronic bronchitis patients for 9, 11, 8 and 3 months, respectively, although variation in their major outer membrane proteins P2 and P5 occurred. We conclude that the hpd gene is conserved during chronic infections of nonencapsulated H. influenzae.
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Publication status
- Published
Journal
GeneISSN
0378-1119Publisher
GeneExternal DOI
Volume
191Page range
57-60ISBN
0378-1119Department affiliated with
- Biochemistry Publications
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- No
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- Yes
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2012-02-06Usage metrics
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