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Leg patterning driven by Proximal-Distal interactions and EGFR signaling
journal contribution
posted on 2023-06-08, 06:40 authored by M I Galindo, Sarah Bishop, S Greig, Juan Pablo Cousowingless and decapentaplegic signaling establishes the proximal-distal axis of Drosophila legs by activating the expression of genes such as Distalless and dachshund in broad proximal-distal domains during early leg development. However, here we show that wingless and decapentaplegic are not required throughout all of proximal-distal development. The tarsus, which has been proposed to be an ancestral structure, is instead defined by the activity of Distalless, dachshund, and a distal gradient of epidermal growth factor receptor (EGFR)-Ras signaling. Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates
History
Publication status
- Published
Journal
ScienceISSN
0036-8075External DOI
Volume
297Page range
256-259Department affiliated with
- Biochemistry Publications
Notes
All authors members of my lab including S. Greig. I managed the project, designed and executed experiments and wrote the paper. Here we amended the existing paradigm for proximal-distal appendage development in arthropods, revealing a wingless and dpp-independent patterning driven by EGFR. Reviewed in Nature and quoted over 50 times.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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