File(s) not publicly available
Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans
journal contribution
posted on 2023-06-07, 15:35 authored by L.C. McKay, Hugo CritchleyHugo Critchley, K. Murphy, R.S.J. Frackowiak, D.R. CorfieldWe investigated the neural basis for spontaneous chemo-stimulated increases in ventilation in awake, healthy humans. Blood oxygen level dependent (BOLD) functional MRI was performed in nine healthy subjects using T2* weighted echo planar imaging. Brain volumes (52 transverse slices, cortex to high spinal cord) were acquired every 3.9 s. The 30 min paradigm consisted of six, 5-min cycles, each cycle comprising 45 s of hypoxic-isocapnia, 45 s of isooxic-hypercapnia and 45 s of hypoxic-hypercapnia, with 55 s of non-stimulatory hyperoxic-isocapnia (control) separating each stimulus period. Ventilation was significantly (p < 0.001) increased during hypoxic-isocapnia, isooxic-hypercapnia and hypoxic-hypercapnia (17.0, 13.8, 24.9 L/min respectively) vs. control (8.4 L/min) and was associated with significant (p < 0.05, corrected for multiple comparisons) signal increases within a bilateral network that included the basal ganglia, thalamus, red nucleus, cerebellum, parietal cortex, cingulate and superior mid pons. The neuroanatomical structures identified provide evidence for the spontaneous control of breathing to be mediated by higher brain centres, as well as respiratory nuclei in the brainstem. © 2009 Elsevier Inc. All rights reserved.
History
Publication status
- Published
Journal
NeuroimageISSN
10538119Publisher
Academic PressExternal DOI
Issue
3Volume
49Page range
2526-2535Department affiliated with
- Clinical and Experimental Medicine Publications
Notes
PubMed ID: 19913627Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2010-10-28Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC