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Adaptive protein evolution in Drosophila
journal contribution
posted on 2023-06-08, 05:16 authored by Nick G C Smith, Adam Eyre-WalkerAdam Eyre-WalkerFor over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level1, 2. Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level3, 4, but it has remained unclear how prevalent adaptive evolution is. Here we present a simple method by which the number of adaptive substitutions can be estimated and apply it to data from Drosophila simulans and D. yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species.
History
Publication status
- Published
Journal
NatureISSN
0028-0836External DOI
Volume
415Page range
1022-1024Pages
3.0Department affiliated with
- Evolution, Behaviour and Environment Publications
Notes
One of the first estimates of the rate of adaptive substitution. Cited by several textbooks. AEW designed the analysis, devised the method, did some of the analysis and wrote the paper. NS, who was a post-doc with AEW at the time, collected the data and did some of the analysis.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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