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Synthesis of agonists and atagonists for central glutamate receptors by a novel 'ring switching' strategy

journal contribution
posted on 2023-06-16, 09:58 authored by Andrew Bowler, Andrew Dinsmore, Paul M Doyle, Douglas W Young
A novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the ß-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors.

History

Publication status

  • Published

Journal

Journal of the Chemical Society, Perkin Transactions 1

ISSN

0300-922X

Publisher

RSC Publishing

Volume

9

Page range

1297 - 1306

ISBN

0300-922X

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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