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Synthesis of agonists and atagonists for central glutamate receptors by a novel 'ring switching' strategy
journal contribution
posted on 2023-06-16, 09:58 authored by Andrew Bowler, Andrew Dinsmore, Paul M Doyle, Douglas W YoungA novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the ß-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors.
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Publication status
- Published
Journal
Journal of the Chemical Society, Perkin Transactions 1ISSN
0300-922XPublisher
RSC PublishingExternal DOI
Volume
9Page range
1297 - 1306ISBN
0300-922XDepartment affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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