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The combined use of stereoelectronic control and ring closing metathesis for the synthesis of (-)-8-epi-swainsonine

journal contribution
posted on 2023-06-07, 20:36 authored by Philip J Parsons, Adrian J Murray, Peter Hitchcock
A novel and efficient synthesis of (-)-8-epi-swainsonine 2 is reported. Stereocontrolled diol formation from the bicyclic alkene 3 followed by a stereoselective vinylation of the aldehyde and ring closing metathesis gave the indolizidine ring system, which was converted into (-)-8-epi-swainsonine 2. © 2007 Elsevier Ltd. All rights reserved.

History

Publication status

  • Published

Journal

Tetrahedron

ISSN

0040-4020

Issue

28

Volume

63

Page range

6485-6492

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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