A

Aherne, Wynne, Maloney, Alison, Prodromou, Chrisostomos, Rowlands, Martin G, Hardcastle, Anthea, Boxall, Katherine, Clarke, Paul, Walton, Michael I, Pearl, Laurence and Workman, Paul (2003) Assays for HSP90 and inhibitors. Methods in Molecular Medicine, 85. pp. 149-161. ISSN 1543-1894

Ahmed, Jubed Omee (2014) Characterisation of the roles of Poz1 and Stn1 at Schizosaccharomyces pombe telomeres. Doctoral thesis (PhD), University of Sussex.

Al-Fartusie, Falah Sumoon Daghal (2011) Engineering and characterisation of novel protein covalent linkages in horseradish peroxidase (HRP): effect on structure and function. Doctoral thesis (DPhil), University of Sussex.

Al-Hilaly, Youssra K, Biasetti, Luca, Brakeman, Ben J, Pollack, Saskia J, Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R, Xue, Wei-Feng and Serpell, Louise C (2016) The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease. Scientific Reports, 6. p. 39171. ISSN 2045-2322

Al-Hilaly, Youssra K, Pollack, Saskia J, Vadukul, Devkee, Citossi, Francesca, Rickard, Janet E, Simpson, Michael, Storey, John M D, Harrington, Charles R, Wischik, Claude M and Serpell, Louise C (2017) Alzheimer's disease-like paired helical filament assembly from truncated tau protein is independent of disulphide cross-linking. Journal of Molecular Biology, 429 (4). pp. 3650-3665. ISSN 0022-2836

Al-Hilaly, Youssra K, Williams, Thomas L, Stewart-Parker, Maris, Ford, Lenzie, Skaria, Eldhose, Cole, Michael, Bucher, William, Morris, Kyle L, Sada, Alaa, Thorpe, Julian R and Serpell, Louise C (2013) A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease. Acta Neuropathologica Communications, 1 (83). pp. 1-17. ISSN 2051-5960

Al-Hilaly, Youssra Kareem (2014) Chemical and biochemical studies of dityrosine cross-link formation in amyloidogenic peptides. Doctoral thesis (PhD), University of Sussex.

Alatwi, Hanan Eid A (2017) The role of the mammalian INO80 in maintaining genome stability. Doctoral thesis (PhD), University of Sussex.

Alcantara, Diana and O'Driscoll, Mark (2014) Congenital microcephaly. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 166 (2). pp. 124-139. ISSN 1552-4868

Alhdad, Gazala M, Zörb, Christian, Al-Azzawi, Mohammed J and Flowers, Timothy J (2015) Is the reduced growth of the halophyte Suaeda maritima under hypoxia due to toxicity of iron or manganese? Environmental and Experimental Botany, 116. pp. 61-70. ISSN 0098-8472

Ali, Ammar A E, Timinszky, Gyula, Arribas-Bosacoma, Raquel, Kozlowski, Marek, Hassa, Paul O, Hassler, Markus, Ladurner, Andreas G, Pearl, Laurence H and Oliver, Antony W (2012) The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nature Structural & Molecular Biology, 9 (7). pp. 685-692. ISSN 1545-9985

Argunhan, Bilge (2016) Interplay netween Dbf4-dependent Cdc7 kinase and polo-like kinase unshackles mitotic recombination mechanisms by promoting synaptonemal complex disassembly. Doctoral thesis (PhD), University of Sussex.

Armes, Helen Elizabeth Harcourt (2017) Implementing super-resolution palm microscopy in fission yeast. Doctoral thesis (PhD), University of Sussex.

Arseni, Lavinia, Lanzafame, Manuela, Compe, Emmanuel, Fortugno, Paola, Afonso-Barroso, Antonio, Peverali, Fiorenzo A, Lehmann, Alan R, Zambruno, Giovanna, Egly, Jean-Marc, Stefanini, Miria and Orioli, Donata (2015) TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin. Proceedings of the National Academy of Sciences, 112 (5). pp. 1499-1504. ISSN 1091-6490

B

Baashen, Mohammed Abdulwahhab M (2013) Synthesis, analysis and biological evaluation of heterocyclic drugs. Doctoral thesis (PhD), University of Sussex.

Bagley, Mark C, Dwyer, Jessica E, Baashen, Mohammed, Dix, Matthew C, Murziani, Paola G S, Rokicki, Michal J, Kipling, David and Davis, Terence (2016) The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells. Organic and Biomolecular Chemistry, 14 (3). pp. 947-956. ISSN 1477-0520

Balan, Nicolae (2014) Analysis of the Epstein-Barr virus transcription factor, Zta. Doctoral thesis (PhD), University of Sussex.

Bannister, Mark L, Alvarez-Laviada, Anita, Thomas, N Lowri, Mason, Sammy A, Coleman, Sharon, du Plessis, Christo L, Moran, Abbygail T, Neill-Hall, David, Osman, Hasnah, Bagley, Mark C, MacLeod, Kenneth T, George, Christopher H and Williams, Alan J (2016) Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. British Journal of Pharmacology, 173 (15). pp. 2446-2459. ISSN 0007-1188

Barri, Muruj Asaad (2015) Functional analysis of motor neuron disease-associated mutations in TAR DNA-binding protein 43 and cytoplasmic dynein heavy chain 1. Doctoral thesis (PhD), University of Sussex.

Bartlett, Edward, Brissett, Nigel C and Doherty, Aidan J (2013) Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proceedings of the National Academy of Sciences, 110 (22). E1984-E1991. ISSN 1091-6490

Bartlett, Edward J (2013) Structural and functional characterisation of the Nonhomologous End-­‐Joining proteins of the archaeon Methanocella Paludicola. Doctoral thesis (PhD), University of Sussex.

Bauer, Matthias R, Jones, Rhiannon N, Baud, Matthias G J, Wilcken, Rainer, Boeckler, Frank M, Fersht, Alan, Joerger, Andreas C and Spencer, John (2016) Harnessing fluorine-sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs. ACS Chemical Biology, 11 (8). pp. 2265-2274. ISSN 1554-8929

Bauer, Matthias R, Krämer, Andreas, Settanni, Giovanni, Jones, Rhiannon N, Ni, Xiaomin, Tareque, Raysa Khan, Fersht, Alan R, Spencer, John and Joerger, Andreas C (2020) Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm. ACS Chemical Biology. ISSN 1554-8929

Bianchi, Julie (2013) Investigating the role of a novel primase-polymerase, PrimPol, in DNA damage tolerance in vertebrate cells. Doctoral thesis (PhD), University of Sussex.

Booth, D A (1974) Food intake compensation for increase or decrease in the protein content of the diet. Behavioral Biology, 12 (1). pp. 31-40. ISSN 0091-6773

Booth, D A (1962) Isolation and assay of gangliosides and their interactions with basic proteins. Journal of Neurochemistry, 9 (3). pp. 265-276. ISSN 0022-3042

Booth, D A (1963) Lipophilic sialic acid derivatives in human erythrocytes. BBA - Biochimica et Biophysica Acta, 70. pp. 486-487. ISSN 0006-3002

Booth, D A (1979) Metabolism and the control of feeding in man and animals. In: Brown, K and Cooper, S J (eds.) Chemical influences on behaviour. Academic Press, London, pp. 79-134. ISBN 9780121367800

Booth, D A (1970) Neurochemical changes correlated with learning and memory retention. In: Ungar, G (ed.) Molecular mechanisms in memory and learning. Plenum Press, New York, pp. 1-57.

Booth, D A (1972) Postabsorptively induced suppression of appetite and the energostatic control of feeding. Physiology and Behavior, 9 (2). pp. 199-202. ISSN 0031-9384

Booth, D A (1978) Prediction of feeding behaviour from energy flows in the rat. In: Booth, D A (ed.) Hunger models: computable theory of feeding control. Academic Press, London, pp. 227-278. ISBN 9780121159504

Booth, D A, Chase, Aileen and Campbell, A T (1970) Relative effectiveness of protein in the late stages of appetite suppression in man. Physiology and Behavior, 5 (11). pp. 1299-1302. ISSN 0031-9384

Booth, D A, Lovett, D and Simson, P C (1970) Subcutaneous dialysis in the study of the effects of nutrients on feeding. Physiology and Behavior, 5 (10). pp. 1201-1203. ISSN 0031-9384

Booth, D A and Simson, P C (1971) Food preferences acquired by association with variations in amino acid nutrition. Quarterly Journal of Experimental Psychology, 23 (1). pp. 135-145. ISSN 1747-0218

Booth, D A and Simson, P C (1974) Taste aversion induced by an histidine-free amino acid load. Physiological Psychology, 2 (3). pp. 349-351. ISSN 0090-5046

Booth, D A and Smith, E B O (1964) Urinary excretion of some purine bases in normal and schizophrenic subjects. British Journal of Psychiatry, 110 (467). pp. 582-587. ISSN 0007-1250

Booth, D A, Stoloff, Robert and Nicholls, Joy (1974) Dietary flavor acceptance in infant rats established by association with effects of nutrient composition. Physiological Psychology, 2 (3(A)). pp. 313-319. ISSN 0889-6313

Booth, D A and Stribling, D (1978) Neurochemistry of appetite mechanisms. Proceedings of the Nutrition Society, 37 (2). pp. 181-191. ISSN 0029-6651

Booth, D A and Toates, F M (1974) A physiological control theory of food intake in the rat: Mark 1. Bulletin of the Psychonomic Society, 3 (6). pp. 442-444. ISSN 0090-5054

Booth, David A (1977) Intake control and energy balance stabilisation by net energy supply. In: Proceedings of 27th International Congress of the International Union of Physiological Sciences (Paris, July 1977). International Union of Physiological Sciences, Paris, 6.18.

Booth, David A and Campbell, Constance S (1975) Relation of fatty acids to feeding behaviour: effects of palmitic acid infusions, lighting variation and pent 4 enoate, insulin or propranolol injection. Physiology and Behavior, 15 (5). pp. 523-535. ISSN 0031-9384

Booth, David A and Jarman, Simon P (1975) Ontogeny and insulin-dependence of the satiation which follows carbohydrate absorption in the rat. Behavioral Biology, 15 (2). pp. 159-172. ISSN 0091-6773

Booth, David A, Love, Edith and Wechsler, Ann (1968) Feeding after a single insulin injection disrupted by puromycin but not actinomycin. Physiology and Behavior, 3 (3). pp. 455-460. ISSN 0031-9384

Booth, David A and Pitt, M Elisabeth (1968) The role of glucose in insulin-induced feeding and drinking. Physiology and Behavior, 3 (3). pp. 447-453. ISSN 0031-9384

Booth, David A and Toates, Frederick M (1978) Matters arising (Rothwell & Stock). No paradox in the control of energy intake. Nature, 275. p. 345. ISSN 0028-0836

Braithwaite, Natalie Emma (2011) Functional genomics and signalling in invasive growth of Schizosaccharomyces pombe. Doctoral thesis (DPhil), University of Sussex.

Brissett, Nigel C, Martin, Maria J, Bartlett, Edward J, Bianchi, Julie, Blanco, Luis and Doherty, Aidan J (2013) Molecular basis for DNA double-strand break annealing and primer extension by a NHEJ DNA polymerase. Cell Reports, 5 (4). pp. 1108-1120. ISSN 2211-1247

Brunton, Holly (2011) Investigating the role of higher order chromatin structure and DNA damage complexity on ATM signalling and G2/M checkpoint arrest. Doctoral thesis (DPhil), University of Sussex.

C

Cadot, Stephanie (2014) Regulatory analysis of Fgf3 and Fgf10 and the role of retinoids in their control. Doctoral thesis (PhD), University of Sussex.

Carr, Antony, Wang, Zhao-Qi, WooKee, Min, Krueger, Anja, Bruhn, Christopher, Li, Tang-Liang, Liu, Cong and Zhou, Zhong-Wei (2013) An essential function for the ATR-Activation-Domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genetics, 9 (8). e1003702. ISSN 1553-7390

Carrière, Yves, Crickmore, Neil and Tabashnik, Bruce E (2015) Optimizing pyramided transgenic Bt crops for sustainable pest management. Nature Biotechnology, 33 (2). pp. 161-168. ISSN 1087-0156

Chambers, Helen (2011) Investigating the effects of repair of DNA single-strand breaks on chromatin structure. Doctoral thesis (DPhil), University of Sussex.

Chang, Pishan, Zuckermann, Alexandra M E, Williams, Sophie, Close, Adam J, Cano-Jaimez, Marife, McEvoy, James P, Spencer, John, Walker, Matthew C and Williams, Robin S B (2015) Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. Journal of Pharmacology and Experimental Therapeutics, 352 (1). pp. 43-52. ISSN 0022-3565

Chen, Lina (2017) Structural and functional studies of the cell cycle regulator RGC-32. Doctoral thesis (PhD), University of Sussex.

Chetwynd, Andrew John (2015) Development of nanoflow liquid chromatography-nanoelectrospray ionization mass spectrometry methodology for improved urine metabolomics. Doctoral thesis (PhD), University of Sussex.

Clemens, Michael J, Elia, Androulla and Morley, Simon J (2013) Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition. PLoS ONE, 8 (8). e71138. ISSN 1932-6203

Cloney, Ross (2011) Involvement of human DNA polymerase kappa in nucleotide excision repair. Doctoral thesis (DPhil), University of Sussex.

Cohen, Jonathan (2004) Shock factor shed by microbe. Nature Medicine, 10 (4). pp. 342-343. ISSN 1078-8956

Coldwell, Mark J, Cowan, Joanne L, Vlasak, Markete, Mead, Abbie, Willett, Mark, Perry, Lisa S and Morley, Simon J (2013) Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis. Cell Cycle, 12 (23). pp. 3615-3628. ISSN 1538-4101

Coppo, Lucia and Ghezzi, Pietro (2011) Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism. Biochemical Society Transactions, 39. pp. 1268-1272. ISSN 0300-5127

Coulon, Stéphane, Ramasubramanyan, Sharada, Alies, Carole, Philippin, Gaëlle, Lehmann, Alan and Fuchs, Robert P (2010) Rad8Rad5/Mms2–Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast. EMBO Journal, 29 (12). pp. 2048-2058. ISSN 0261-4189

Covo, Shay, de Villartay, Jean-Pierre, Jeggo, Penny A and Livneh, Zvi (2009) Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Research, 37 (20). pp. 6737-6745. ISSN 0305-1048

Cox, Oakley B, Krojer, Tobias, Collins, Patrick, Monteiro, Octovia, Talon, Romain, Bradley, Anthony, Fedorov, Oleg, Amin, Jahangir, Marsden, Brian D, Spencer, John, von Delft, Frank and Brennan, Paul E (2016) A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chemical Science, 7 (3). pp. 2322-2330. ISSN 2041-6520

Cuomo, Maria Emanuela, Platt, Georgina M, Pearl, Laurence H and Mittnacht, Sibylle (2011) Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition. Journal of Biological Chemistry, 286 (11). pp. 9713-9725. ISSN 0021-9258

D

Damerell, David Robert (2011) The computational analysis of post-translational modifications. Doctoral thesis (DPhil), University of Sussex.

David, Arthur, Lange, Anke, Abdul-Sada, Alaa, Tyler, Charles R and Hill, Elizabeth M (2016) Disruption of the prostaglandin metabolome and characterization of the pharmaceutical exposome in fish exposed to wastewater treatment works effluent as revealed by nanoflow-nanospray mass spectrometry-based metabolomics. Environmental Science & Technology, 51 (1). pp. 616-624. ISSN 0013-936X

Davidson, Calvin Ray (2012) Towards the matter compiler: looking ahead to computer-controlled molecular assembly. Doctoral thesis (DPhil), University of Sussex.

De Marco, Giuseppe (2011) Molecular simulations of conformational transitions in biomolecules using a novel computational tool. Doctoral thesis (DPhil), University of Sussex.

De Seabra Rodrigues Dias, Ivo Ricardo (2012) Effects of virulence and fraction 1 antigens from Yersinia pestis on the human innate immune system. Doctoral thesis (PhD), University of Sussex.

Domanska, Barbara (2016) Mode of action of a human cancer cell active toxin (Parasporin-3) from Bacillus thuringiensis. Doctoral thesis (PhD), University of Sussex.

Durand-Dubief, Mickaël, Will, William Ryan, Petrini, Edoardo, Theodorou, Delphine, Harris, Rachael R., Crawford, Margaret R., Paszkiewicz, Konrad, Krueger, Felix, Correra, Rosa Maria, Vetter, Anna T., Miller, J. Ross, Kent, Nicholas A. and Varga-Weisz, Patrick (2012) SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae. PLoS Genetics, 8 (9). e1002974. ISSN 1553-7390

Dwyer, Jessica E (2016) Building molecules for the modulation of age-related diseases. Doctoral thesis (PhD), University of Sussex.

E

Elhigazi, Alicia (2019) Investigating the specificity of Bacillus thuringiensis Cry41Aa toxin through mutagenesis in domain II loops. Doctoral thesis (PhD), University of Sussex.

Elliott, Catherine Rebecca (2013) The over-expression, purification and crystallisation of the alternative oxidase. Doctoral thesis (PhD), University of Sussex.

Etheridge, Thomas J, Boulineau, Rémi L, Herbert, Alex, Watson, Adam T, Daigaku, Yasukazu, Tucker, Jem, George, Sophie, Jönsson, Peter, Palayret, Matthieu, Lando, David, Laue, Ernest, Osborne, Mark A, Klenerman, David, Lee, Steven F and Carr, Antony M (2014) Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy. Nucleic Acids Research, 42 (19). e146. ISSN 0305-1048

F

Fallas, Andrea Jennifer (2011) C1, SAP and ZiCo: structural studies of three metal‑binding proteins from a crystallographic perspective. Doctoral thesis (DPhil), University of Sussex.

Flower, Kirsty (2011) Methylation dependent interactions of viral transcription factor Zta with DNA. Doctoral thesis (DPhil), University of Sussex.

Fontebasso, Yari (2011) Novel insights into the DNA interstrand cross-link repair in Schizosaccharomyces pombe: characterisation of Fan1 through standard and high-throughput genetic analysis. Doctoral thesis (DPhil), University of Sussex.

G

Gamper, Frederick (2011) Dysregulated toll-like receptor mechanisms: the cause of atherosclerosis? Doctoral thesis (DPhil), University of Sussex.

Garg, Mansi, Gurung, Resham L, Mansoubi, Sahar, Ahmed, Jubed O, Davé, Anoushka, Watts, Felicity Z and Bianchi, Alessandro (2014) Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association. EMBO Reports, 15 (8). pp. 871-877. ISSN 1469-3178

Garg Aggarwal, Mansi (2017) Characterization of the role of SUMO in telomere length homeostasis and overhang processing at yeast telomeres. Doctoral thesis (PhD), University of Sussex.

Garrett, Caroline Alice (2012) Consequences of the ‘Legs at odd angles’ mutation within the motor protein dynein and its possible implications in neurological disease. Doctoral thesis (PhD), University of Sussex.

George, Zenas Okon (2011) Expression and genetic manipulation of Bacillus thuringiensis toxins for improved toxicity and development of a protocol for in vivo selection of toxin variants with improved activity. Doctoral thesis (DPhil), University of Sussex.

Gibson, E L and Booth, D A (1986) Acquired protein appetite in rats: dependence on a protein specific need state. Experientia, 42. pp. 1003-1004. ISSN 0014-4754

Gligoris, Thomas G, Scheinost, Johanna C, Bürmann, Frank, Petela, Naomi, Chan, Kok-Lung, Uluocak, Pelin, Beckouët, Frédéric, Gruber, Stephan, Nasmyth, Kim and Löwe, Jan (2014) Closing the cohesin ring: structure and function of its Smc3-kleisin interface. Science, 346 (6212). pp. 963-967. ISSN 1095-9203

Godfrey, Anja Katharina (2019) Investigation of the Epstein-Barr virus’ latent to lytic cycle switch in epithelial cells suggests an interplay between host transcription co-factors and the viral early lytic cycle protein Zta. Doctoral thesis (PhD), University of Sussex.

Gomez Herreros, Fernando, Schuurs-Hoeijmakers, Janneke H M, McCormack, Mark, Greally, Marie T, Rulten, Stuart, Romero-Granados, Rocio, Counihan, Timothy J, Chaila, Elijah, Conroy, Judith, Ennis, Sean, Delanty, Norman, Cortes-Ledesma, Felipe, de Brouwer, Arjan P M, Cavalleri, Gianpiero L, El-Khamisy, Sherif F, de Vries, Bert B A and Caldecott, Keith W (2014) TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics, 46 (5). pp. 516-521. ISSN 1061-4036

Gray, Stephen (2013) Investigating the molecular mechanisms of meiotic recombination. Doctoral thesis (PhD), University of Sussex.

Gray, Stephen, Allison, Rachal M, Garcia, Valerie, Goldman, Alastair S H and Neale, Matthew J (2013) Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR). Open Biology, 3 (7). p. 130019. ISSN 2046-2441

Grundy, Gabrielle J, Polo, Luis M, Zeng, Zhihong, Rulten, Stuart L, Hoch, Nicolas C, Pathompong, Paomephan, Xu, Yingqi, Sweet, Steve M, Thorne, Alan W, Oliver, Antony W, Matthews, Steve J, Pearl, Laurence H and Caldecott, Keith W (2016) PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature Communications, 7 (1). a12404 1-12. ISSN 2041-1723

Gwon, Gwang Hyeon, Kim, Youngran, Liu, Yaqi, Watson, Adam, Jo, Aera, Etheridge, Thomas, Yuan, Fenghua, Zhang, Yanbin, Kim, YoungChang, Carr, Antony and Cho, Yunje (2014) Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5′ flap DNA: basis of interstrand cross-link repair by FAN1. Genes & Development, 28. pp. 2276-2290. ISSN 0890-9369

H

Harflett, Claudia (2012) Zinc accumulation and its effects on herbivory and competitive ability, in metallicolous populations of Rumex acetosa L. Doctoral thesis (DPhil), University of Sussex.

Hart, LesleyRuth, Rauch, Anita, Carr, Antony, Vermeesch, Joris R and O'Driscoll, Mark (2014) LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition. Disease Models and Mechanisms, 7. pp. 535-545. ISSN 1754-8403

Hartley, Susan E, Eschen, Rene, Horwood, Julia M, Gange, Alan C and Hill, Elizabeth M (2014) Infection by a foliar endophyte elicits novel arabidopside-based plant defence reactions in its host, Cirsium arvense. New Phytologist, 205 (2). pp. 816-827. ISSN 0028-646X

Hopkins, Suzanna (2017) Drug target development and analysis of genome stability in cancer cells lacking the BAF180 subunit of the PBAF remodelling complex. Doctoral thesis (PhD), University of Sussex.

Hornyak, Peter (2016) Structural and mechanistic studies of DNA repair proteins. Doctoral thesis (PhD), University of Sussex.

Hu, Bin, Liao, Chunyan, Millson, Stefan H, Mollapour, Mehdi, Prodromou, Chrisostomos, Pearl, Laurence H, Piper, Peter W and Panaretou, Barry (2005) Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Molecular Microbiology, 55 (6). pp. 1735-1750. ISSN 0950-382X

Humphrey, Laurence J (2016) Transcription initiation in Streptomyces coelicolor A3(2). Doctoral thesis (PhD), University of Sussex.

J

Joerger, Andreas C, Bauer, Matthias R, Wilcken, Rainer, Baud, Matthias G J, Harbrecht, Hannes, Exner, Thomas E, Boeckler, Frank M, Spencer, John and Fersht, Alan R (2015) Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53. Structure, 23 (12). pp. 2246-2255. ISSN 0969-2126

Johnson, Dominic (2017) Investigating double-strand break formation and repair in meiosis. Doctoral thesis (PhD), University of Sussex.

Jones, Christopher I and Newbury, Sarah F (2010) Functions of microRNAs in Drosophila development. Biochemical Society Transactions, 38 (4). pp. 1137-1143. ISSN 1470-8752

Jones, R G and Booth, D A (1975) Low dose response for 2 deoxy D glucose induced feeding and the involvement of peripheral factors. Physiology and Behavior, 15 (1). pp. 85-90. ISSN 0031-9384

Jongjitwimol, Jirapas (2015) Investigating the role of SUMOylation of eukaryotic translation initiation factors. Doctoral thesis (PhD), University of Sussex.

Jongjitwimol, Jirapas, Feng, Min, Zhou, Lihong, Wilkinson, Oliver, Small, Lauren, Baldock, Robert, Taylor, Deborah L, Smith, Duncan, Bowler, Lucas, Morley, Simon J and Watts, Felicity (2014) The S. pombe translation initiation factor eIF4G is sumoylated and associates with the SUMO protease Ulp2. PLoS ONE, 9 (5). e94182. ISSN 1932-6203

K

Kakarougkas, Andreas David William (2012) The role of ATM signalling and its mediator proteins in DNA double strand break repair. Doctoral thesis (PhD), University of Sussex.

Karlsson, Questa Hope (2013) Mutational analysis and protein interactions of Epstein-Barr virus protein Zta, with reference to ZtaRh, a homologue from Cercopithecine herpesvirus-15. Doctoral thesis (PhD), University of Sussex.

Keen, Benjamin A (2015) Molecular dissection of PrimPol, a novel primase-polymerase involved in damage tolerance during DNA replication in eukaryotic cells. Doctoral thesis (PhD), University of Sussex.

Keen, Benjamin A, Jozwiakowski, Stanislaw K, Bailey, Laura J, Bianchi, Julie and Doherty, Aidan J (2014) Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Nucleic Acids Research, 42 (9). pp. 5830-5845. ISSN 0305-1048

Keith, Brian J, Jozwiakowski, Stanislaw K and Connolly, Bernard A (2013) A plasmid-based lacZα gene assay for DNA polymerase fidelity measurement. Analytical Biochemistry, 433 (2). pp. 153-161. ISSN 0003-2697

Kler, Rantej Singh (2014) Metal oxide nanomaterials and their application in solar photoelectrolysis of water. Doctoral thesis (PhD), University of Sussex.

Komulainen, Emilia, Pennicott, Lewis, Le Grand, Darren and Caldecott, Keith (2019) Deazaflavin inhibitors of TDP2 with cellular activity can affect etoposide influx and/or efflux. ACS Chemical Biology, 14 (6). pp. 1110-1114. ISSN 1554-8929

Kozakova, Lucie, Vondrova, Lucie, Stejskal, Karel, Charalabous, Panagoula, Kolesar, Peter, Lehmann, Alan R, Uldrijan, Stjepan, Sanderson, Christopher M, Zdrahal, Zbynek and Palecek, Jan J (2015) The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Cell Cycle, 14 (6). pp. 920-930. ISSN 1538-4101

Krishnan, Vidisha (2013) Investigation of parasporins, the cytotoxic proteins from the bacterium Bacillus thuringiensis. Doctoral thesis (PhD), University of Sussex.

Kukalev, Alexander, Ng, Yiu-Ming, Ju, Limei, Saidi, Amal, Lane, Sophie, Mondragon, Angeles, Dormann, Dirk, Walker, Sophie E, Grey, William, Ho, Philip Wing-Lok, Stephens, David N, Carr, Antony M, Lamsa, Karri, Tse, Eric and Yu, Veronica (2016) Deficiency of Cks1 leads to learning and long-term memory defects and p27 dependentformation of neuronal cofilin aggregates. Cerebral Cortex, 27 (1). pp. 11-23. ISSN 1047-3211

L

Lane, Rosemary (2021) Glioblastoma (GBM) and GBM stem cell subtyping and identification of kinases implicated in GBM differentiation. Doctoral thesis (PhD), University of Sussex.

Lee, Chieh-Ju (2014) Visualizing chromosomal rearrangements caused by replication fork stalling in a single cell. Doctoral thesis (PhD), University of Sussex.

Lehmann, Alan R (2001) Research note: xeroderma pigmentosum in the United Kingdom. Photochemistry and Photobiology, 91 (2). pp. 484-485. ISSN 0031-8655

Li, Zhaobo (2017) Identification of degradation pathways for HSP90 client proteins. Doctoral thesis (PhD), University of Sussex.

Librizzi, Mariangela, Chiarelli, Roberto, Bosco, Liana, Sansook, Supojjanee, Gascon, Jose M, Spencer, John, Caradonna, Fabio and Luparello, Claudio (2015) The histone deacetylase inhibitor JAHA down-regulates pERK and global DNA methylation in MDA-MB231 breast cancer cells. Materials, 8 (10). pp. 7041-7047. ISSN 1996-1944

Librizzi, Mariangela, Spencer, John and Luparello, Claudio (2016) Biological effect of a hybrid anticancer agent based on kinase and histone deacetylase inhibitors on triple-negative (MDA-MB231) breast cancer cells. International Journal of Molecular Sciences, 17 (8). p. 1235. ISSN 1422-0067

Licona, Cynthia, Spaety, Marie-Elodie, Capuozzo, Antonella, Ali, Moussa, Santamaria, Rita, Armant, Olivier, Delalande, Francois, Van Dorsselaer, Alain, Cianferani, Sarah, Spencer, John, Pfeffer, Michel, Mellitzer, Georg and Gaiddon, Christian (2017) A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8 (2). pp. 2568-2584. ISSN 1949-2553

Lin, Su-Jiun (2011) Structure/function analysis of the essential protein Rad4TopBP1 in S. pombe. Doctoral thesis (DPhil), University of Sussex.

Lineham, Ella Kim (2019) Targeting the translational machinery in aggressive cancers. Doctoral thesis (PhD), University of Sussex.

Longo, Alessandra, Librizzi, Mariangela, Chuckowree, Irina S, Baltus, Christine B, Spencer, John and Luparello, Claudio (2015) Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells. Molecules, 20 (6). pp. 9879-9889. ISSN 1420-3049

Lynch, Anthony, Harvey, James, Aylott, Michael, Nicholas, Emma, Burman, Mark, Siddiqui, Ayesha, Walker, Sarah and Rees, Robert (2003) Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity. Mutagenesis, 18 (4). pp. 345-53. ISSN 0267-8357

M

Malik, Reshad K J, Ghurye, Rohit R, Lawrence-Watt, Diana J and Stewart, Helen J S (2009) Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. Glycobiology, 19 (12). pp. 1402-7. ISSN 1460-2423

Marshall, Karen E, Marchante, Ricardo, Xue, Wei-Feng and Serpell, Louise C (2014) The relationship between amyloid structure and cytotoxicity. Prion, 8 (2). pp. 5-4. ISSN 1933-6896

Maunders, Michelle J, Petti, Lisa and Rowe, Martin (1994) Precipitation of the Epstein-Barr virus protein EBNA 2 by an EBNA 3c-specific monoclonal antibody. Journal of General Virology, 75 (4). pp. 769-778. ISSN 0022-1317

May, Benjamin (2016) A biochemical and molecular characterisation of the alternative oxidases. Doctoral thesis (PhD), University of Sussex.

McClellan, Michael J, Khasnis, Sarika, Wood, C David, Palermo, Richard D, Schlick, Sandra N, Kanhere, Aditi S, Jenner, Richard G and West, Michelle J (2012) Downregulation of Integrin Receptor-Signaling Genes by Epstein-Barr Virus EBNA 3C via Promoter-Proximal and -Distal Binding Elements. Journal of Virology, 86 (9). pp. 5165-5178. ISSN 0022-538X

McClellan, Michael John (2015) Cellular reprogramming by Epstein-Barr virus nuclear antigens. Doctoral thesis (PhD), University of Sussex.

McDonald, Jed (2012) Investigating the potential interaction of RBM4 with Translational machinery in C2C12 cells undergoing myogenic differentiation. Doctoral thesis (DPhil), University of Sussex.

McGregor, Grant Alexander (2017) Investigation into the role of the SMC5/6 complex in human cells. Doctoral thesis (PhD), University of Sussex.

Meier, Christoph, Brookings, Daniel C, Ceska, Thomas A, Doyle, Carl, Gong, Haiping, McMillan, David, Saville, Giles P, Mushtaq, Adeel, Knight, David, Reich, Stefanie, Pearl, Laurence H, Powell, Keith A, Savva, Renos and Allen, Rodger A (2012) Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. Journal of Structural Biology, 177 (2). pp. 329-334. ISSN 1095-8657

Mercer, Brenda (2013) An investigation into the function of sumoylation in genomic stability in schizosaccharomyces pombe. Doctoral thesis (PhD), University of Sussex.

Meyer, Philipe, Prodromou, Chrisostomos, Hu, Bin, Vaughan, Cara, Roe, S Mark, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2003) Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Molecular Cell, 11 (3). pp. 647-658. ISSN 1097-2765

Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23 (6). pp. 1402-1410. ISSN 0261-4189

Miles, Catrina Anne (2017) An investigation into factors affecting condensin association with mitotic centromeres. Doctoral thesis (PhD), University of Sussex.

Millson, Stefan H, Truman, Andrew W, King, Victoria, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2005) A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Eukaryotic Cell, 4 (5). pp. 849-860. ISSN 1535-9778

Millson, Stefan H, Truman, Andrew W, Wolfram, Francis, King, Victoria, Panaretou, Barry, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2004) Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach. Cell Stress and Chaperones, 9 (4). pp. 359-368. ISSN 1355-8145

Mirzaa, Ghyada M, Vitre, Benjamin, Carpenter, Gillian, Abramowicz, Iga, Gleeson, Joseph G, Paciorkowski, Alex R, Cleveland, Don W, Dobyns, William B and O'Driscoll, Mark (2014) Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Human Genetics, 133 (8). pp. 1023-1039. ISSN 0340-6717

Mishra, Ruchir (2011) Characterisation of insecticide resistance in Plutella xylostella (the diamondback moth). Doctoral thesis (DPhil), University of Sussex.

Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W, Xu, Wanping, Vaughan, Cara K, Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W, Trepel, Jane B, Prodromou, Chrisostomos, Pearl, Laurence H and Neckers, Len (2011) Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Molecular Cell, 41 (6). pp. 672-681. ISSN 1097-2765

Moore, Duncan Alan (2016) FUS, RNA and the nucleolus. Doctoral thesis (PhD), University of Sussex.

Moore, Thomas Oliver (2016) Synthetic strategies towards challenging PPI drug targets. Doctoral thesis (PhD), University of Sussex.

Morris, Edward P, Rivera-Calzada, Angel, da Fonseca, Paula C A, Llorca, Oscar, Pearl, Laurence H and Spagnolo, Laura (2011) Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Research, 39 (13). pp. 5757-5767. ISSN 1362-4962

Morris, Kyle (2012) The assembly and structure of self-assembling peptides: molecular to supramolecular. Doctoral thesis (PhD), University of Sussex.

Morris, Kyle L, Chen, Lin, Raeburn, Jaclyn, Sellick, Owen R, Cotanda, Pepa, Paul, Alison, Griffiths, Peter C, King, Stephen M, O’Reilly, Rachel K, Serpell, Louise C and Adams, Dave J (2013) Chemically programmed self-sorting of gelator networks. Nature Communications, 4. p. 1480. ISSN 2041-1723

Morris, Kyle L, Rodger, Alison, Hicks, Matthew R, Debulpaep, Maya, Schymkowitz, Joost, Rousseau, Frederic and Serpell, Louise C (2012) Exploring the sequence-structure relationship for amyloid peptides. Biochemical Journal, 450. pp. 275-283. ISSN 0264-6021

Mullen, Lisa, Seavill, Miles, Hammouz, Raneem, Bottazzi, Barbara, Chan, Philippe, Vaudry, David and Ghezzi, Pietro (2015) Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome. Scientific Reports, 5 (1). a14630. ISSN 2045-2322

N

Newman, J C and Booth, D A (1981) Gastrointestinal and metabolic consequences of a rat's meal on maintenance diet ad libitum. Physiology and Behavior, 27 (5). pp. 929-939. ISSN 0031-9384

Nichols, Tyler Woodrow (2022) Expanding the scope of the Bohlmann-Rahtz reaction: new routes to 3-nitropyridines, ẟ-carbolines, and β-carbolines. Masters thesis (MPhil), University of Sussex.

Niimi, Atsuko, Brown, Stephanie, Sabbioneda, Simone, Kannouche, Patricia L., Scott, Andrew, Yasui, Akira, Green, Catherine M. and Lehmann, Alan R. (2008) Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proceedings of the National Academy of Sciences, 105 (42). pp. 16125-16130. ISSN 0027-8424

Ntai, Ioanna (2017) TDP2 as a biomarker of sensitivity to TOP2 targeting agents and as a novel therapeutic target. Doctoral thesis (PhD), University of Sussex.

O

Ojeniyi, Opeoluwa O. (2017) Investigating the mechanism of cellular gene activation and repression by the EBV transcription factor EBNA 2. Masters thesis (MPhil), University of Sussex.

P

Palermo, Richard D, Webb, Helen M, Gunnell, Andrea and West, Michelle J (2008) Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2. Biochemical Society Transactions, 36 (4). pp. 625-8. ISSN 0300-5127

Panaretou, Barry, Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1998) ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO Journal, 17 (16). pp. 4829-4836. ISSN 0261-4189

Panaretou, Barry, Siligardi, Giuliana, Meyer, Philippe, Maloney, Alison, Sullivan, Janis K, Singh, Shradha, Millson, Stefan H, Clarke, Paul A, Naaby-Hansen, Soren, Stein, Rob, Cramer, Rainer, Mollapour, Mehdi, Workman, Paul, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2002) Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Molecular Cell, 10 (6). pp. 1307-1318. ISSN 1097-2765

Panaretou, Barry, Sinclair, Kirsty, Prodromou, Chrisostomos, Johal, Jasvinder, Pearl, Laurence and Piper, Peter W (1999) The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections. Microbiology, 145 (12). pp. 3455-3463. ISSN 1350-0872

Pannell, Sarah Esme (2011) Structural determinants of peroxidase activities. Doctoral thesis (DPhil), University of Sussex.

Parry-Morris, Sarah (2015) High-throughput screening technologies for identification and expression of functional domains of proteins of biomedical importance. Doctoral thesis (PhD), University of Sussex.

Paulin, F E, West, M J, Sullivan, N F, Whitney, R L, Lyne, L and Willis, A E (1996) Aberrant translational control of the c-myc gene in multiple myeloma. Oncogene, 13 (3). pp. 505-513. ISSN 0950-9232

Pearl, Laurence H and Prodromou, Chrisostomos (2000) Structure and in vivo function of Hsp90. Current Opinion in Structural Biology, 10 (1). pp. 46-51. ISSN 0959-440X

Pearl, Laurence H and Prodromou, Chrisostomos (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. Annual Review of Biochemistry, 75. pp. 271-294. ISSN 0066-4154

Pearl, Laurence H and Prodromou, Chrisostomos (2001) Structure, function, and mechanism of the Hsp90 molecular chaperone. Advances in Protein Chemistry, 59. pp. 157-186. ISSN 0065-3233

Peter, Nisha (2017) Characterisation of the phosphatase control system that prevents premature mitotic entry in mammalian cells. Doctoral thesis (PhD), University of Sussex.

Peters, Nicholas E, Ferguson, Brian J, Mazzon, Michela, Fahy, Aodhnait S, Krysztofinska, Ewelina, Arribas-Bosacoma, Raquel, Pearl, Laurence H, Ren, Hongwei and Smith, Geoffrey L (2013) A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus. PLoS Pathogens, 9 (10). e1003649. ISSN 1553-7374

Phelps, Sarah (2016) Analysis of the Ies6 subunit of the INO80 chromatin remodelling complex. Doctoral thesis (PhD), University of Sussex.

Philpott, Amelia (2011) Investigations into the biochemical and cellular biology of a cytoplasmic dynein mutation, abnormal rear leg (Arl). Doctoral thesis (DPhil), University of Sussex.

Pilcher, Charles W T and Booth, David A (1975) Effect of cycloheximide on the long term retention of reversed paw preference in the rat. Experimental Brain Research, 23 (2 supp). p. 318. ISSN 0014-4819

Pollard, Hilary J, Willett, Mark and Morley, Simon J (2014) mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation. Cell Cycle, 13 (16). pp. 2517-2525. ISSN 1538-4101

Preece, Lewis (2012) Studies toward a total synthesis of Lactonamycin. Doctoral thesis (DPhil), University of Sussex.

Priora, Raffaella, Coppo, Lucia, Salzano, Sonia, Di Simplicio, Paolo and Ghezzi, Pietro (2010) Measurement of mixed disulfides including glutathionylated proteins. In: Cadenas, Enrique and Packer, Lester (eds.) Thiol Redox Transitions in Cell Signaling, Part A: Chemistry and Biochemistry of Low Molecular Weight and Protein Thiols. Methods in Enzymology, 473 . Elsevier, pp. 149-159. ISBN 978-0-12-381345-9

Prodromou, Chrisostomos, Artymiuk, Peter J and Guest, John R (1992) The aconitase of Escherichia coli. Nucleotide sequence of the aconitase gene and amino acid sequence similarity with mitochondrial aconitases, the iron-responsive-element-binding protein and isopropylmalate isomerases. European Journal of Biochemistry, 204 (2). pp. 599-609. ISSN 0014-2956

Prodromou, Chrisostomos, Haynes, Megan J and Guest, John R (1991) The aconitase of Escherichia coli: purification of the enzyme and molecular cloning and map location of the gene (acn). Journal of General Microbiology, 137 (11). pp. 2505-2515. ISSN 0022-1287

Prodromou, Chrisostomos, Panaretou, Barry, Chohan, Shahzad, Siligardi, Giuliano, O'Brien, Ronan, Ladbury, John E, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (2000) The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO Journal, 19 (16). pp. 4383-92. ISSN 0261-4189

Prodromou, Chrisostomos and Pearl, Laurence H (1992) Recursive PCR: a novel technique for total gene synthesis. Protein Engineering, Design and Selection, 5 (8). pp. 827-829. ISSN 1741-0126

Prodromou, Chrisostomos and Pearl, Laurence H (2003) Structure and functional relationships of Hsp90. Current Cancer Drug Targets, 3 (5). pp. 301-323. ISSN 1568-0096

Prodromou, Chrisostomos, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (1997) A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nature Structural Biology, 4 (6). pp. 477-482. ISSN 1072-8368

Prodromou, Chrisostomos, Savva, Renos and Driscoll, Paul C (2007) DNA fragmentation-based combinatorial approaches to soluble protein expression: Part I. Generating DNA fragment libraries. Drug Discovery Today, 12 (21-22). pp. 931-938. ISSN 1359-6446

Prodromou, Chrisostomos, Siligardi, Giuliano, O'Brien, Ronan, Woolfson, Derek N, Regan, Lynne, Panaretou, Barry, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO Journal, 18 (3). pp. 754-762. ISSN 0261-4189

R

Radkov, S A, Bain, M, Farrell, P J, West, M, Rowe, M and Allday, M J (1997) Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21. Journal of Virology, 71 (11). pp. 8552-8562. ISSN 0022-538X

Radkov, Stoyan A, Touitou, Robert, Brehm, Alex, Rowe, Martin, West, Michelle J, Kouzarides, Tony and Allday, Martin J (1999) Epstein-Barr Virus Nuclear Antigen 3C Interacts with Histone Deacetylase to Repress Transcription. Journal of Virology, 73 (7). pp. 5688-5697. ISSN 0022-538X

Ramasubramanyan, Sharada, Osborn, Kay, Al-Mohammad, Rajaei, Naranjo Perez-Fernandez, Ijiel B, Zuo, Jianmin, Balan, Nicolae, Godfrey, Anja, Patel, Harshil, Peters, Gordon, Rowe, Martin, Jenner, Richard G and Sinclair, Alison J (2015) Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression. Nucleic Acids Research, 43 (7). pp. 3563-3577. ISSN 0305-1048

Rasheduzzaman, Chowdhury, Brissett, Nigel, Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S, Clifton, Ian J, Ge, Wei, Kershaw, Nadia J, Fox, Gavin C, Muniz, Joao R C, Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S, Kavanagh, Kathryn L, von Delft, Frank, Oppermann, Udo, McDonough, Michael A, Doherty, Aidan and Schofield, Christopher J (2014) Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510 (7505). pp. 422-426. ISSN 0028-0836

Redfern, Oliver C, Harrison, Andrew, Dallman, Tim, Pearl, Frances M G and Orengo, Christine A (2007) CATHEDRAL: A Fast and Effective Algorithm to Predict Folds and Domain Boundaries from Multidomain Protein Structures. PLoS Computational Biology, 3 (11). e232. ISSN 1553-734X

Reich, Stephanie, Puckey, Loretto H, Cheetham, Caroline L, Harris, Richard, Ali, Ammar A E, Bhattacharyya, Uma, Maclagan, Kate, Powell, Keith A, Prodromou, Chrisostomos, Pearl, Laurence H, Driscoll, Paul C and Savva, Renos (2006) Combinatorial domain hunting: an effective approach for the identification of soluble protein domains adaptable to high-throughput applications. Protein Science, 15 (10). pp. 2356-2365. ISSN 0961-8368

Richardson, Christopher J, Gao, Qiong, Mitsopoulous, Costas, Zvelebil, Marketa, Pearl, Laurence H and Pearl, Frances M G (2009) MoKCa database - mutations of kinases in cancer. Nucleic Acids Research, 37 (S1). D824-D831. ISSN 0305-1048

Richer, Edward John Albert (2012) Synergistic innate immune recognition of Coxsackievirus B5 by RIG-I and MDA5. Doctoral thesis (DPhil), University of Sussex.

Rivera-Calzada, Angel, Pal, Mohinder, Muñoz-Hernández, Hugo, Luque-Ortega, Juan R, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Prodromou, Chrisostomos, Pearl, Laurence H and llorca, Oscar (2017) The structure of the R2TP complex defines a platform for recruiting diverse client proteins to the HSP90 molecular chaperone system. Structure, 25 (7). pp. 1145-1152. ISSN 0969-2126

Roe, Mark, Wahab, Ben, Torok, Zsolt, Horvath, Ibolya, Vigh, Laszlo and Prodromou, Chrisostomos (2018) Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection. Frontiers in Molecular Biosciences, 5 (51). pp. 1-14. ISSN 2296-889X

Roe, S Mark, Ali, Maruf M U, Meyer, Philippe, Vaughan, Cara K, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2004) The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell, 116 (1). pp. 87-98. ISSN 0092-8674

Roe, S Mark, Prodromou, Chrisostomos, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. Journal of Medicinal Chemistry, 42 (2). pp. 260-266. ISSN 0022-2623

Roeseler de Rivera, Francois-Xavier P.G. (2011) The effects of LPS plus pro-inflammatory cytokines on glycogen synthesis in C2C12 myocytes. Doctoral thesis (DPhil), University of Sussex.

Rowlands, Martin G, Newbatt, Yvette M, Prodromou, Chrisostomos, Pearl, Laurence, Workman, Paul and Aherne, Wynne (2004) High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Analytical Biochemistry, 327 (2). pp. 176-183. ISSN 0003-2697

Rudd, Sean G (2013) Cellular and biochemical characterisation of PrimPol, a novel eukaryotic primase-polymerase involved in DNA damage tolerance. Doctoral thesis (PhD), University of Sussex.

S

Salek, Reza M, Williams, Mark A, Prodromou, Chrisostomos, Pearl, Laurence H and Ladbury, John E (2002) Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone. Journal of Biomolecular NMR, 23 (4). pp. 327-328. ISSN 0925-2738

Sansook, Supojjanee, Hassell-Hart, Storm, Ocasio, Cory and Spencer, John (2019) Ferrocenes in medicinal chemistry; a personal perspective. Journal of Organometallic Chemistry, 905. pp. 1-17. ISSN 0022-328X

Sansook, Supojjanee, Lineham, Ella, Hassell-Hart, Storm, Tizzard, Graham J, Coles, Simon J, Spencer, John and Morley, Simon J (2018) Probing the anticancer action of novel ferrocene analogues of MNK inhibitors. Molecules, 23 (2126). pp. 1-13. ISSN 1420-3049

Sansook, Supojjanee, Tuo, Wei, Bollier, Mélanie, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Fredérique, Leleu-Chavain, Natascha, Farce, Amaury, Tizzard, Graham J, Coles, Simon J, Spencer, John and Millet, Regis (2018) Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands. Future Medicinal Chemistry, 10 (6). pp. 631-638. ISSN 1756-8919

Sansook, Supojjanee, Tuo, Wei, Lemaire, Lucas, Tourteau, Aurélien, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Frédérique, Leleu-Chavain, Natascha, Tizzard, Graham J, Coles, Simon J, Millet, Régis and Spencer, John (2016) Synthesis of bioorganometallic nanomolar-potent CB2agonists containing a ferrocene unit. Organometallics, 35 (19). pp. 3361-3368. ISSN 0276-7333

Savva, Renos, Prodromou, Chrisostomos and Driscoll, Paul C (2007) DNA fragmentation based combinatorial approaches to soluble protein expression Part II: library expression, screening and scale-up. Drug Discovery Today, 12 (21-22). pp. 939-947. ISSN 1359-6446

Schalbetter, Stephanie (2012) Genome instability induced by structured DNA and replication fork restart. Doctoral thesis (DPhil), University of Sussex.

Schalbetter, Stephanie A, Mansoubi, Sahar, Chambers, Anna L, Downs, Jessica A and Baxter, Jonathan (2015) Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proceedings of the National Academy of Sciences, 112 (33). E4565-E4570. ISSN 0027-8424

Schreurs, Ann-Sofie (2012) In vivo structure-mediated regulation of ribonucleotide reductase in S. pombe. Doctoral thesis (PhD), University of Sussex.

Sethi, Mieran, Lehmann, Alan R and Fassih, Hiva (2013) Xeroderma pigmentosum: a multidisciplinary approach. European Medical Journal Dermatol. pp. 54-63. ISSN 1472-0213

Sgarlata, Carmelo, Oliveri, Valentina and Spencer, John (2015) A 8-hydroxyquinoline-cyclodextrin conjugate as an efficient chelating agent for cobalt(II) and nickel(II) in neutral aqueous solution. European Journal of Inorganic Chemistry, 2015 (36). pp. 5886-5891. ISSN 1434-1948

Sharp, Swee Y, Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A, Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thomas P, Cheung, Kwai-Ming J, Ball, Karen, Hayes, Angela, Raynaud, Florence, Marais, Richard, Pearl, Laurence, Eccles, Sue, Aherne, Wynne, McDonald, Edward and Workman, Paul (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Research, 67 (5). pp. 2206-2216. ISSN 0008-5472

Sharp, Swee Y, Prodromou, Chrisostomos, Boxall, Kathy, Powers, Marissa V, Holmes, Joanna L, Box, Gary, Matthews, Thomas P, Cheung, Kwai-Ming J, Kalusa, Andrew, James, Karen, Hayes, Angela, Hardcastle, Anthea, Dymock, Brian, Brough, Paul A, Barril, Xavier, Cansfield, Julie E, Wright, Lisa, Surgenor, Allan, Foloppe, Nicolas, Hubbard, Roderick E, Aherne, Wynne, Pearl, Laurence, Jones, Keith, McDonald, Edward, Raynaud, Florence, Eccles, Sue, Drysdale, Martin and Workman, Paul (2007) Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Molecular Cancer Therapeutics, 6 (4). pp. 1198-1211. ISSN 1535-7163

Shearman, Julia (2016) The regulation of respiration on plant growth and development of Fallopia japonica, Japanese knotweed. Doctoral thesis (PhD), University of Sussex.

Siligardi, Giuliano, Hu, Bin, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2004) Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. Journal of Biological Chemistry, 279 (50). pp. 51989-51998. ISSN 0021-9258

Siligardi, Giuliano, Panaretou, Barry, Meyer, Philippe, Singh, Shradha, Woolfson, Derek N, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2002) Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. Journal of Biological Chemistry, 277 (23). pp. 20151-20159. ISSN 0021-9258

Siligardi, Giuliano, Zhang, Minghao and Prodromou, Chrisostomos (2018) The stoichiometric interaction of the Hsp90-Sgt1-Rar1 complex by CD and SRCD spectroscopy. Frontiers in Molecular Biosciences, 4 (95). pp. 1-13. ISSN 2296-889X

Simson, P C and Booth, D A (1973) Subcutaneous release of amino acid loads on food and water intake in the rat. Physiology and Behavior, 11 (3). pp. 329-336. ISSN 0031-9384

Simson, P C and Booth, D A (1974) The rejection of a diet which has been associated with a single administration of a histidine free amino acid mixture. British Journal of Nutrition, 31 (3). pp. 285-296. ISSN 0007-1145

Simson, Peter C and Booth, David A (1974) Dietary aversion established by a deficient load. Specificity to the amino acid omitted from a balanced mixture. Pharmacology Biochemistry and Behavior, 2 (4). pp. 481-485. ISSN 0091-3057

Singh, Sunny Kumar (2015) Biophysical characterisation of LcrH, a class II chaperone of the type III secretion system. Doctoral thesis (PhD), University of Sussex.

Small, Lauren (2014) An investigation into the function of the SUMOylation of Nse2 and PCNA in S. pombe. Doctoral thesis (PhD), University of Sussex.

Smalley, Sarah (2013) Investigating the use of connectivity mapping to manipulate MGMT protein levels in T98G glioblastoma multiforme cells. Doctoral thesis (PhD), University of Sussex.

Smith, J R, de Billy, E, Hobbs, S, Powers, M, Prodromou, C, Pearl, L, Clarke, P A and Workman, P (2013) Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. Oncogene, 34 (1). pp. 15-26. ISSN 0950-9232

Spencer, John (2016) [Review] Stefan Bräse (2015) Privileged scaffolds in medicinal chemistry: design, synthesis, evaluation. ChemMedChem, 11 (10). p. 1107. ISSN 1860-7179

Spencer, John and Coaker, Hannah (2015) Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19–20 May 2015. Future Medicinal Chemistry, 7 (14). pp. 1839-1842. ISSN 1756-8919

Strain-Damerell, Claire Michelle (2011) Functional analysis of Rex, a sensor of the NADH/NAD+ redox poise in Streptomyces coelicolor. Doctoral thesis (DPhil), University of Sussex.

Sun, Dijue (2016) Characterizing the regulation and function of Zip1 in Saccharomyces cerevisiae meiosis. Doctoral thesis (PhD), University of Sussex.

T

Tabib-Salazar, Aline (2012) Structural and functional studies on RbpA, a RNA polymerase binding protein in streptomyces coelicolor A3 (2). Doctoral thesis (PhD), University of Sussex.

Toates, F M and Booth, D A (1974) Control of food intake by energy supply. Nature, 251. pp. 710-711. ISSN 0028-0836

Towler, Benjamin P, Jones, Christopher I, Viegas, Sandra C, Apura, Patricia, Waldron, Joseph A, Smalley, Sarah K, Arraiano, Cecilia M and Newbury, Sarah F (2015) The 3’-5’ exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs. RNA Biology, 12 (7). pp. 728-741. ISSN 1547-6286

Traylen, Christopher (2016) To elucidate the Epstein-Barr virus replisome. Doctoral thesis (PhD), University of Sussex.

Truman, Andrew W, Millson, Stefan H, Nuttall, James M, King, Victoria, Mollapour, Medhi, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2006) Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryotic Cell, 5 (11). pp. 1914-1924. ISSN 1535-9778

Truman, Andrew W, Millson, Stefan H, Nuttall, James M, Mollapour, Mehdi, Prodromou, Chrisostomos and Piper, Peter W (2007) In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity. Eukaryotic Cell, 6 (4). pp. 744-752. ISSN 1535-9778

Tuo, Wei, Bollier, Mélanie, Leleu-Chavain, Natascha, Lemaire, Lucas, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Frédérique, Szczepanski, Fabien, Spencer, John, Chavatte, Philippe and Millet, Régis (2018) Development of novel oxazolo[5,4- d ]pyrimidines as competitive CB 2 neutral antagonists based on scaffold hopping. European Journal of Medicinal Chemistry, 146. pp. 68-78. ISSN 0223-5234

Tuschl, Karin, Meyer, Esther, Valdivia, Leonardo E, Zhao, Ningning, Dadswell, Chris, Abdul-Sada, Alaa, Hung, Christina Y, Simpson, Michael A, Chong, W K, Jacques, Thomas S, Woltjer, Randy L, Eaton, Simon, Gregory, Allison, Sanford, Lynn, Kara, Eleanna, Houlden, Henry, Cuno, Stephan M, Prokisch, Holger, Valletta, Lorella, Tiranti, Valeria, Younis, Rasha, Maher, Eamonn R, Spencer, John, Straatman-Iwanowska, Ania, Gissen, Paul, Selim, Laila A M, Pintos-Morell, Guillem, Coroleu-Lletget, Wifredo, Mohammad, Shekeeb S, Yoganathan, Sangeetha, Dale, Russell C, Thomas, Maya, Rihel, Jason, Bodamer, Olaf A, Enns, Caroline A, Hayflick, Susan J, Clayton, Peter T, Mills, Philippa B, Kurian, Manju A and Wilson, Stephen W (2016) Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia. Nature Communications, 7 (1). a11601. ISSN 2041-1723

V

Vejrup-Hansen, Rasmus, Fleck, Oliver, Landvad, Katrine, Fahnøe, Ulrik, Broendum, Sebastian S, Schreurs, Ann-Sofie, Kragelund, Birthe B, Carr, Antony M, Holmberg, Christian and Nielsen, Olaf (2014) Spd2 assists Spd1 in modulation of RNR architecture but does not regulate deoxynucleotide pools. Journal of Cell Science, 127. pp. 2460-2470. ISSN 0021-9533

Velupillai, Srikannathasan, Sáez, Laura Díaz, Krojer, Tobias, Bennett, James, Ruda, Gian Filippo, Szommer, Tamas, Straub, Verena, Nunez Alonso, Graciela, Siejka, Paulina, Bradley, Anthony, Talon, Romain, Fairhead, Michael, Elkins, Jon, London, Nir, Spencer, John, von Delft, Frank, Fedorov, Oleg, Brennan, Paul and Huber, Kilian (2018) Human peroxisomal coenzyme A diphosphatase (NUDT7): a target enabling package (TEP). Zenodo. pp. 1-15.

W

Walker, Sarah A (2012) Investigating the role of the ATR-dependent DNA damage response in the aetiology of microcephalic primordial dwarfism disorders. Doctoral thesis (PhD), University of Sussex.

Wardlaw, Christopher (2014) Protein-protein interactions underlying damage checkpoint activation in S. pombe. Doctoral thesis (PhD), University of Sussex.

Watson, Adam T, Daigaku, Yasukazu, Mohebi, Saed, Etheridge, Thomas, Chahwan, Charley, Murray, Johanne M and Carr, Antony M (2013) Optimisation of the Schizosaccharomyces pombe urg1 expression system. PLoS ONE, 8 (12). e83800. ISSN 1932-6203

Watts, Felicity Z (2013) Starting and stopping SUMOylation. What regulates the regulator? Chromosoma, 122 (6). pp. 451-463. ISSN 0009-5915

Watts, Felicity Z, Baldock, Robert, Jongjitwimol, Jirapas and Morley, Simon J (2014) Weighing up the possibilities: controlling translation by ubiquitylation and sumoylation. Translation, 2 (2). e959366-1. ISSN 2169-074X

West, M J, Sullivan, N F and Willis, A E (1995) Translational upregulation of the c-myc oncogene in Bloom's syndrome cell lines. Oncogene, 11 (12). pp. 2515-2524. ISSN 0950-9232

West, Michelle J, Stoneley, Mark and Willis, Anne E (1998) Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway. Oncogene, 17 (6). pp. 769-780. ISSN 0950-9232

Wheeler, Vanessa C, Prodromou, Chrisostomos, Pearl, Laurence H, Williamson, Robert and Coutelle, Charles (1996) Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect. Gene, 169 (2). pp. 251-255. ISSN 0378-1119

Whitwood, Jennifer (2014) Using mating-type switching to investigate Smc5/6 function in Schizosaccharomyces pombe. Doctoral thesis (PhD), University of Sussex.

Willett, Mark, Brocard, Michele, Pollard, Hilary J and Morley, Simon J (2013) mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration. The Biochemical Journal, 452 (1). pp. 45-55. ISSN 1470-8728

Willis, A E, Paulin, F E, West, M J and Whitney, R L (1997) Investigation of aberrant translational control of c-myc in cell lines derived from patients with multiple myeloma. Current Topics in Microbiology and Immunology, 224. pp. 269-276. ISSN 0070-217X

Woodbine, Lisa, Gennery, Andrew R and Jeggo, Penny A (2014) Reprint of “The clinical impact of deficiency in DNA non-homologousend-joining”. DNA Repair, 17. pp. 9-20. ISSN 1568-7864

Woodbine, Lisa, Haines, Jackie, Coster, Margaret, Barazzuol, Lara, Ainsbury, Elizabeth, Sienkiewicz, Zenon and Jeggo, Penny (2015) The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds. International Journal of Radiation Biology, 91 (6). pp. 495-499. ISSN 0955-3002

Y

Young, Luke (2014) Structure, function and mechanism of the alternative oxidases. Doctoral thesis (PhD), University of Sussex.

Z

Zhang, Minghao, Windheim, Mark, Roe, S Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos and Pearl, Laurence H (2005) Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Molecular Cell, 20 (4). pp. 525-538. ISSN 1097-2765

Zheng, Christina L, Wang, Nicholas J, Chung, Jongsuk, Moslehi, Homayoun, Sanborn, J Zachary, Hur, Joseph S, Collison, Eric A, Vemula, Swapna S, Naujokas, Agne, Chiotti, Kami E, Cheng, Jeffrey B, Fassihi, Hiva, Blumberg, Andrew J, Bailey, Celeste V, Fudem, Gary M, Mihm, Frederick G, Cunningham, Bati B, Neuhaus, Isaac M, Liao, Wilson, Oh, Dennis H, Cleaver, James E, LeBoit, Philip E, Costello, Joseph F, Lehmann, Alan, Gray, Joe W, Spellman, Paul T, Aaron, Sarah T, Huh, Nam, Purdom, Elizabeth and Cho, Raymond J (2014) Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. Cell Reports, 9 (4). pp. 1228-1234. ISSN 2211-1247

Zheng, Yupeng, Sweet, Steve M M, Popovic, Relja, Martinez-Garcia, Eva, Tipton, Jeremiah D, Thomas, Paul M, Licht, Jonathan D and Kelleher, Neil L (2012) Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490, 109 (34). pp. 13549-13554. ISSN 1091-6490

Zheng, Yupeng, Tipton, Jeremiah D, Thomas, Paul M, Kelleher, Neil L and Sweet, Steve M M (2014) Site-specific human histone H3 methylation stability: fast K4me3 turnover. Proteomics, 14 (19). pp. 2190-2199. ISSN 1615-9853