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Number of items at this level: 32.

Article

Baig, Sonia, Kothandaraman, Narasimhan, Manikandan, Jayapal, Rong, Li, EE, Kim Huey, Hill, Jeffrey, Lai, Chin Wee, Tan, Wan Yu, Yeoh, Felicia, Kale, Anita, Su, Lin Lin, Biswas, Arijit, Vasoo, Sheila and Choolani, Mahesh (2014) Proteomic analysis of human placental syncytiotrophoblast microvesicles in preeclampsia. Clinical Proteomics, 11. pp. 1-8. ISSN 1559-0275

Barroca-Aubry, Nadine, Benchekroun, Mohamed, Gomes, Filipe and Bonnaffé, David (2013) p-Methoxybenzyl-N-phenyl-2,2,2-trifluoroacetimidate: a versatile reagent for mild acid catalyzed etherification. Tetrahedron Letters, 54 (37). pp. 5118-5121. ISSN 0040-4039

Benchekroun, Mohamed, Bartolini, Manuela, Egea, Javier, Romero, Alejandro, Soriano, Elena, Pudlo, Marc, Luzet, Vincent, Andrisano, Vincenza, Jimeno, María-Luisa, López, Manuela G, Wehle, Sarah, Gharbi, Tijani, Refouvelet, Bernard, de Andrés, Lucía, Herrera-Arozamena, Clara, Monti, Barbara, Bolognesi, Maria Laura, Rodríguez-Franco, María Isabel, Decker, Michael, Marco-Contelles, José and Ismaili, Lhassane (2015) Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids. ChemMedChem, 10 (3). pp. 523-539. ISSN 18607179

Benchekroun, Mohamed, Ismaili, Lhassane, Pudlo, Marc, Luzet, Vincent, Gharbi, Tijani, Refouvelet, Bernard and Marco-Contelles, José (2015) Donepezil–ferulic acid hybrids as anti-Alzheimer drugs. Future Medicinal Chemistry, 7 (1). pp. 15-21. ISSN 1756-8919

Benchekroun, Mohamed, Romero, Alejandro, Egea, Javier, León, Rafael, Michalska, Patrycja, Buendía, Izaskun, Jimeno, María Luisa, Jun, Daniel, Janockova, Jana, Sepsova, Vendula, Soukup, Ondrej, Bautista-Aguilera, Oscar M, Refouvelet, Bernard, Ouari, Olivier, Marco-Contelles, José and Ismaili, Lhassane (2016) The antioxidant additive approach for Alzheimer’s disease therapy: new ferulic (lipoic) acid plus melatonin modified tacrines as cholinesterases inhibitors, direct antioxidants, and nuclear factor (erythroid-derived 2)-like 2 activators. Journal of Medicinal Chemistry, 59 (21). pp. 9967-9973. ISSN 0022-2623

Benson, Matthew, Tinsley, Caroline, Waite, Aidan, Carlisle, Francesca, Sweet, Steve, Ehler, Elisabeth, George, Christopher, Lai, Anthony, Martin-Rendon, Enca and Blake, Derek (2017) Ryanodine receptors are part of the myospryn complex in cardiac muscle. Scientific Reports, 7 (6312). pp. 1-12. ISSN 2045-2322

Coote, K J, Paisley, D, Czarnecki, S, Tweed, M, Watson, H, Young, A, Sugar, R, Vyas, M, Smith, N J, Baettig, U, Groot-Kormelink, P J, Gosling, M, Lock, R, Ethell, B, Williams, G, Schumacher, A, Harris, J, Abraham, W M, Sabater, J, Poll, C T, Faller, T, Collingwood, S P and Danahay, H (2015) NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia. British Journal of Pharmacology, 172 (11). pp. 2814-2826. ISSN 0007-1188

Derudas, Marco, Vanpouille, Christophe, Carta, Davide, Zicari, Sonia, Andrei, Graciela, Snoeck, Robert, Brancale, Andrea, Margolis, Leonid, Balzarini, Jan and McGuigan, Christopher (2017) Virtual Screening of acyclovir derivatives as potential antiviral agents: design, synthesis, and biological evaluation of new acyclic nucleoside ProTides. Journal of Medicinal Chemistry, 60 (18). pp. 7876-7896. ISSN 0022-2623

Dgachi, Youssef, Bautista-Aguilera, Oscar, Benchekroun, Mohamed, Martin, Hélène, Bonet, Alexandre, Knez, Damijan, Godyń, Justyna, Malawska, Barbara, Gobec, Stanislav, Chioua, Mourad, Janockova, Jana, Soukup, Ondrej, Chabchoub, Fakher, Marco-Contelles, José and Ismaili, Lhassane (2016) Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer’s disease. Molecules, 21 (5). p. 634. ISSN 1420-3049

Dgachi, Youssef, Ismaili, Lhassane, Knez, Damijan, Benchekroun, Mohamed, Martin, Hélène, Szałaj, Natalia, Wehle, Sarah, Bautista-Aguilera, Oscar M, Luzet, Vincent, Bonnet, Alexandre, Malawska, Barbara, Gobec, Stanislav, Chioua, Mourad, Decker, Michael, Chabchoub, Fakher and Marco-Contelles, José (2016) Synthesis and biological assessment of racemic benzochromenopyrimidinimines as antioxidant, cholinesterase, and Aβ1−42 aggregation inhibitors for Alzheimer's disease therapy. ChemMedChem, 11 (12). pp. 1318-1327. ISSN 1860-7179

Hui Liu, Bee, Jobichen, Chacko, Chia, C S Brian, Chan, Tim Hon Man, Tang, Jing Ping, Chung, Theodora X Y, Li, Jia, Poulsen, Anders, Hung, Alvin W, Koh-Stenta, Xiaoying, Tan, Yaw Sing, Verma, Chandra S, Tan, Hong Kee, Wu, Chan-Shuo, Li, Feng, Hill, Jeffrey and others, (2018) Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 115 (30). pp. 7119-7128. ISSN 1091-6490

Ismaili, Lhassane, Refouvelet, Bernard, Benchekroun, Mohamed, Brogi, Simone, Brindisi, Margherita, Gemma, Sandra, Campiani, Giuseppe, Filipic, Slavica, Agbaba, Danica, Esteban, Gerard, Unzeta, Mercedes, Nikolic, Katarina, Butini, Stefania and Marco-Contelles, José (2017) Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. Progress in Neurobiology, 151. pp. 4-34. ISSN 0301-0082

Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, O'Reilly, Molly, Derudas, Marco, Cantillon, Daire M, Goodyear, Richard J, Secker, Abigail, Baxendale, Sarah, Bulley, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J and Richardson, Guy P (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. Journal of Clinical Investigation Insight, 2 (24). a96773 1-16. ISSN 2379-3708

Kirkwood, Nerissa K, O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J, Huckvale, Rosemary, van Netten, Sietse M, Ward, Simon E, Richardson, Guy P and Kros, Corné Kros (2017) d-Tubocurarine and berbamine: alkaloids that are permeant blockers of the hair cell's mechano-electrical transducer channel and protect from aminoglycoside toxicity. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102

Koh-Stenta, Xiaoying, Joy, Joma, Poulsen, Anders, Li, Rong, Tan, Yvonne, Shim, Yoonjung, Min, Jung-Hyun, Wu, Liling, Ngo, Anna, Peng, Jianhe, Seetoh, Wei Guang, Cao, Jing, Wee, John Liang Kuan, Kwek, Perlyn Zekui, Hung, Alvin, Lakshmanan, Umayal, Flotow, Horst, Guccione, Ernesto and Hill, Jeffrey (2014) Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques. Biochemical Journal, 461 (2). pp. 323-334. ISSN 0264-6021

Komulainen, Emilia, Pennicott, Lewis, Le Grand, Darren and Caldecott, Keith (2019) Deazaflavin inhibitors of TDP2 with cellular activity can affect etoposide influx and/or efflux. ACS Chemical Biology, 14 (6). pp. 1110-1114. ISSN 1554-8929

Kraft, L, Roe, M, Gill, R and Atack, J R (2018) Co‐crystallization of human inositol monophosphatase with the lithium mimetic L‐690,330. Acta Crystallographica Section D: Structural Biology, 74. pp. 973-978. ISSN 0907-4449

Li, Yan, Zhang, Zhenzhen, Phoo, Wint Wint, Loh, Ying Ru, Li, Rong, Yang, Hai Yan, Jansson, Anna E, Hill, Jeffrey, Keller, Thomas H, Nacro, Kassoum, Luo, Dahai and Kang, CongBao (2018) Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor. Structure, 26 (4). pp. 555-564. ISSN 0969-2126

Madan, B, Ke, Z, Harmston, N, Ho, S Y, Frois, A O, Alam, J, Jeyaraj, D A, Pendharkar, V, Ghosh, K, Virshup, I H, Manoharan, V, Ong, E H Q, Sangthongpitag, K, Hill, J, Petretto, E and others, (2016) Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene, 35. pp. 2197-2207. ISSN 0950-9232

Miller, Andrew T, Dahlberg, Carol, Sandberg, Mark L, Wen, Ben G, Beisner, Daniel R, Hoerter, John A H, Parker, Albert, Schmedt, Christian, Stinson, Monique, Avis, Jacqueline, Cienfuegos, Cynthia, McPate, Mark, Tranter, Pamela, Gosling, Martin, Groot-Kormelink, Paul J, Dawson, Janet, Pan, Shifeng, Tian, Shin-Shay, Seidel, H Martin and Cooke, Michael P (2015) Inhibition of the inositol kinase Itpkb augments calcium signaling in lymphocytes and reveals a novel strategy to treat autoimmune disease. PLoS ONE, 10 (6). e0131071. ISSN 1932-6203

Mok, Myth T, Zhou, Jingying, Tang, Wenshu, Zeng, Xuezhen, Oliver, Antony W, Ward, Simon E and Cheng, Alfred S L (2018) CCRK is a novel signalling hub exploitable in cancer immunotherapy. Pharmacology and Therapeutics, 186. pp. 138-151. ISSN 0163-7258

Naret, Timothée, Bignon, Jérôme, Bernadat, Guillaume, Benchekroun, Mohamed, Levaique, Helene, Lenoir, Christine, Dubois, Joelle, Pruvost, Alain, Saller, François, Borgel, Delphine, Manoury, Boris, Leblais, Veronique, Darrigrand, Romain, Apcher, Sébastien, Brion, Jean-Daniel, Schmitt, Etienne, Leroux, Frédéric R, Alami, Mouad and Hamze, Abdallah (2018) A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. European Journal of Medicinal Chemistry, 143. pp. 473-490. ISSN 0223-5234

Noble, James William, Almalki, Rehab, Roe, Mark, Duman, Ramona, Wagner, Armin and Atack, John (2018) The X-ray structure of human calbindin-D28K: an improved model. Acta Crystallographica Section D: Structural Biology, 74 (10). pp. 1008-1014. ISSN 2059-7983

O'Reilly, Molly, Kirkwood, Nerissa K, Kenyon, Emma J, Huckvale, Rosemary, Cantillon, Daire M, Waddell, Simon J, Ward, Simon E, Richardson, Guy P, Kros, Corné J and Derudas, Marco (2019) Design, synthesis and biological evaluation of a new series of carvedilol derivatives that protect sensory hair cells from aminoglycoside-induced damage by blocking the mechanoelectrical transducer channel. Journal of Medicinal Chemistry, 62 (11). pp. 5312-5329. ISSN 0022-2623

Peng, Jianhe, Cao, Jing, Ng, Fui Mee and Hill, Jeffrey (2017) Pseudomonas aeruginosa develops Ciprofloxacin resistance from low to high level with distinctive proteome changes. Journal of Proteomics, 152. pp. 75-87. ISSN 1874-3919

Reuillon, Tristan, Ward, Simon and Beswick, Paul (2016) AMPA receptor positive allosteric modulators: potential for the treatment of neuropsychiatric and neurological disorders. Current Topics in Medicinal Chemistry, 16 (29). pp. 3536-3565. ISSN 1568-0266

Romero, Eugénie, Minard, Corinne, Benchekroun, Mohamed, Ventre, Sandrine, Retailleau, Pascal, Dodd, Robert H and Cariou, Kevin (2017) Base-mediated generation of ketenimines from ynamides: direct access to azetidinimines by an imino staudinger synthesis. Chemistry - A European Journal, 23 (53). pp. 12991-12994. ISSN 0947-6539

Tomassoli, Isabelle, Herlem, Guillaume, Picaud, Fabien, Benchekroun, Mohamed, Bautista-Aguilera, Oscar M, Luzet, Vincent, Jimeno, María-Luisa, Gharbi, Tijani, Refouvelet, Bernard and Ismaili, Lhassane (2016) Synthesis, regioselectivity, and DFT analysis of new antioxidant pyrazolo[4,3-c]quinoline-3,4-diones. Chemical Monthly / Monatshefte für Chemie, 147 (6). pp. 1069-1079. ISSN 0026-9247

West, Ryan, Cunningham, Thomas, Pennicott, Lewis, Rao, Srinivasa and Ward, Simon (2018) Toward more drug like inhibitors of trypanosome alternative oxidase. ACS Infectious Diseases, 4 (4). pp. 592-604. ISSN 2373-8227

West, Ryan A, O'Doherty, Oran G, Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E, Rao, Srinivasa P S, Williams, Gareth and Ward, Simon E (2017) African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry, 141. pp. 676-689. ISSN 0223-5234

Patent

The University of Sussex; Ward, Simon; Beswick, Paul; Penicott, Lewis; Reuillon, Tristan (2018) AMPA receptor potentiators. PCT/GB2018/050370.

The University of Sussex, Cardiff University, University College Cardiff Consultants Limited; Ward, Simon; Beswick, Paul; Pennicott, Lewis; Reuillon, Tristan; Chuckowree, Irina; Villalonga-Barber, Carolina; Porter, Roderick (2019) Compounds that modulates AMPA receptor function. PCT/GB2019/050578.

This list was generated on Thu Oct 1 08:57:25 2020 BST.