Henderson, Scott H, Sorrell, Fiona, Bennett, James, Fedorov, Oleg, Hanley, Marcus T, Godoi, Paulo H, Ruela De Sousa, Roberta, Robinson, Sean, Ashall-Kelly, Alexander, Hopkins Navratilova, Iva, Walter, Daryl S, Elkins, Jonathan M and Ward, Simon E (2021) Discovery and characterization of selective and ligand-efficient DYRK inhibitors. Journal of Medicinal Chemistry, 64 (15). pp. 11709-11728. ISSN 0022-2623

Slusarczyk, Magdalena, Serpi, Michaela, Ghazaly, Essam, Kariuki, Benson M, McGuigan, Christopher and Pepper, Chris (2021) Single Diastereomers of the Clinical Anticancer ProTide Agents NUC-1031 and NUC-3373 Preferentially Target Cancer Stem Cells In Vitro. Journal of Medicinal Chemistry, 64 (12). pp. 8179-8193. ISSN 0022-2623

O'Reilly, Molly, Kirkwood, Nerissa K, Kenyon, Emma J, Huckvale, Rosemary, Cantillon, Daire M, Waddell, Simon J, Ward, Simon E, Richardson, Guy P, Kros, Corné J and Derudas, Marco (2019) Design, synthesis and biological evaluation of a new series of carvedilol derivatives that protect sensory hair cells from aminoglycoside-induced damage by blocking the mechanoelectrical transducer channel. Journal of Medicinal Chemistry, 62 (11). pp. 5312-5329. ISSN 0022-2623

Corcoran, David B, Lewis, Thomas, Nahar, Kazi S, Jamshidi, Shirin, Fegan, Christopher, Pepper, Chris, Thurston, David E and Rahman, Khondaker Miraz (2019) Effects of systematic shortening of noncovalent C8 side chain on the cytotoxicity and NF-κB inhibitory capacity of pyrrolobenzodiazepines (PBDs). Journal of Medicinal Chemistry, 62 (4). pp. 2127-2139. ISSN 0022-2623

Derudas, Marco, Vanpouille, Christophe, Carta, Davide, Zicari, Sonia, Andrei, Graciela, Snoeck, Robert, Brancale, Andrea, Margolis, Leonid, Balzarini, Jan and McGuigan, Christopher (2017) Virtual Screening of acyclovir derivatives as potential antiviral agents: design, synthesis, and biological evaluation of new acyclic nucleoside ProTides. Journal of Medicinal Chemistry, 60 (18). pp. 7876-7896. ISSN 0022-2623

Tuo, Wei, Leleu-Chavain, Natascha, Spencer, John, Sansook, Supojjanee, Millet, Regis and Chavatte, Philippe (2017) Therapeutic potential of fatty acid amide hydrolase, monoacylglycerol lipase, and N-acylethanolamine acid amidase inhibitors. Journal of Medicinal Chemistry, 60 (1). pp. 4-46. ISSN 0022-2623

Benchekroun, Mohamed, Romero, Alejandro, Egea, Javier, León, Rafael, Michalska, Patrycja, Buendía, Izaskun, Jimeno, María Luisa, Jun, Daniel, Janockova, Jana, Sepsova, Vendula, Soukup, Ondrej, Bautista-Aguilera, Oscar M, Refouvelet, Bernard, Ouari, Olivier, Marco-Contelles, José and Ismaili, Lhassane (2016) The antioxidant additive approach for Alzheimer’s disease therapy: new ferulic (lipoic) acid plus melatonin modified tacrines as cholinesterases inhibitors, direct antioxidants, and nuclear factor (erythroid-derived 2)-like 2 activators. Journal of Medicinal Chemistry, 59 (21). pp. 9967-9973. ISSN 0022-2623

Myrianthopoulos, Vassilios, Gaboriaud-Kolar, Nicolas, Tallant, Cynthia, Hall, Michelle-Lynn, Grigoriou, Stylianos, Brownlee, Peter Moore, Fedorov, Oleg, Rogers, Catherine, Heidenreich, David, Wanior, Marek, Drosos, Nikolaos, Mexia, Nikitia, Savitsky, Pavel, Bagratuni, Tina, Kastritis, Efstathios, Terpos, Evangelos, Filippakopoulos, Panagis, Müller, Susanne, Skaltsounis, Alexios-Leandros, Downs, Jessica Ann, Knapp, Stefan and Mikros, Emmanuel (2016) Discovery and optimization of a selective ligand for the switch/sucrose nonfermenting-related bromodomains of polybromo protein-1 by the use of virtual screening and hydration analysis. Journal of Medicinal Chemistry, 59 (19). pp. 8787-8803. ISSN 0022-2623

Ferla, Salvatore, Aboraia, Ahmed S, Brancale, Andrea, Pepper, Christopher J, Zhu, Jinge, Ochalek, Justin T, DeLuca, Hector F and Simons, Claire (2014) Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. Journal of Medicinal Chemistry, 57 (18). pp. 7702-7715. ISSN 0022-2623

Sheldrake, Helen M, Travica, Sandra, Johansson, Inger, Loadman, Paul M, Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J, Reuillon, Tristan, Shnyder, Steven D, Mkrtchian, Souren, Searcey, Mark, Ingelman-Sundberg, Magnus, Patterson, Laurence H and Pors, Klaus (2013) Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity. Journal of Medicinal Chemistry, 56 (15). pp. 6273-6277. ISSN 0022-2623

Sutherlin, Daniel P, Bao, Linda, Berry, Megan, Castanedo, Georgette, Chuckowree, Irina, Dotson, Jenna, Folks, Adrian, Friedman, Lori, Goldsmith, Richard, Gunzner, Janet, Heffron, Timothy, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Murray, Jeremy, Nonomiya, Jim, Pang, Jodie, Pegg, Niel, Prior, Wei Wei, Rouge, Lionel, Salphati, Laurent, Sampath, Deepak, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wei, BinQing, Wiesmann, Christian, Wu, Ping, Zhu, Bing-Yan and Olivero, Alan (2011) Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. Journal of Medicinal Chemistry, 54 (21). pp. 7579-7587. ISSN 0022-2623

Caldwell, John J, Welsh, Emma J, Matjissen, Cornelis, Anderson, Victoria E, Antoni, Laurent, Boxall, Kathy, Urban, Frederique, Hayes, Angela, Raynaud, Florence I, Rigoreau, Laurent J M, Raynham, Tony, Aherne, G Wynne, Pearl, Laurence H, Oliver, Antony W, Garrett, Michelle D and Collins, Ian (2011) Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2. Journal of Medicinal Chemistry, 54 (2). pp. 580-590. ISSN 0022-2623

Ward, Simon E, Harries, Mark, Aldegheri, Laura, Austin, Nigel E and et al, (2011) Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators. Journal of Medicinal Chemistry, 54 (1). pp. 78-94. ISSN 0022-2623

Leslie, Colin P, Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M, Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J, Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarlo, Pizzi, Domenica A, Stasi, Luigi P, Tibasco, Jessica, Vong, Antonio, Ward, Simon E and Zonzini, Laura (2010) Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT(1A/B/D) Receptor Antagonist. Journal of Medicinal Chemistry, 53 (23). pp. 8228-8240. ISSN 0022-2623

Ward, Simon, Harries, M, Aldegheri, L, Andreotti, D and et al, (2010) Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator. Journal of Medicinal Chemistry, 53 (15). pp. 5801-5812. ISSN 0022-2623

Derudas, Marco, Carta, Davide, Brancale, Andrea, Vanpouille, Christophe, Lisco, Andrea, Margolis, Leonid, Balzarini, Jan and McGuigan, Christopher (2009) The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition. Journal of Medicinal Chemistry, 52 (17). pp. 5520-5530. ISSN 0022-2623

Brough, Paul A., Pearl, Laurence H., Prodromou, Chrisostomos and et al, (2008) 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. Journal of Medicinal Chemistry, 51 (2). pp. 196-218. ISSN 0022-2623

Ward, Simon E, Eddershaw, Peter J, Scott, Claire M, Gordon, Laurie J, Lovell, Peter J, Moore, Susan H, Smith, Paul W, Starr, Kathryn R, Thewlis, Kevin M and Watson, Jeannette M (2008) Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. Journal of Medicinal Chemistry, 51 (10). pp. 2887-2890. ISSN 0022-2623

Martin, Christine J, Gaisser, Sabine, Challis, Iain R, Carletti, Isabelle, Wilkinson, Barrie, Gregory, Matthew, Prodromou, Chrisostomos, Roe, S Mark, Pearl, Laurence H, Boyd, Susan M and Zhang, Ming-Qiang (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. Journal of Medicinal Chemistry, 51 (9). pp. 2853-2857. ISSN 0022-2623

Zhang, Ming-Qiang, Gaisser, Sabine, Nur-E-Alam, Mohammad, Sheehan, Lesley S, Vousden, William A, Gaitatzis, Nikolaos, Peck, Gerrard, Coates, Nigel J, Moss, Steven J, Radzom, Markus, Foster, Teresa A, Sheridan, Rose M, Gregory, Matthew A, Roe, Susan M, Prodromou, Chrisostomos, Pearl, Laurence, Boyd, Susan M, Wilkinson, Barrie and Martin, Christine J (2008) Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. Journal of Medicinal Chemistry, 51 (18). pp. 5494-5497. ISSN 0022-2623

Sechi, Mario, Bacchi, Alessia, Carcelli, Mauro, Compari, Carlotta, Duce, Elenia, Fisicaro, Emilia, Rogolino, Dominga, Gates, Paul, Derudas, Marco, Al-Mawsawi, Laith Q and Neamati, Nouri (2006) From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by β-diketo acid metal complexes. Journal of Medicinal Chemistry, 49 (14). pp. 4248-4260. ISSN 0022-2623

Ritchie, Timothy J, Dziadulewicz, Edward K, Culshaw, Andrew J, Müller, Werner, Burgess, Gillian M, Bloomfield, Graham C, Drake, Gillian S, Dunstan, Andrew R, Beattie, David, Hughes, Glyn A, Ganju, Pam, McIntyre, Peter, Bevan, Stuart J, Davis, Clare and Yaqoob, Mohammed (2004) Potent and orally bioavailable non-peptide antagonists at the human bradykinin B1 receptor based on a 2-Alkylamino-5-sulfamoylbenzamide core. Journal of Medicinal Chemistry, 47 (19). pp. 4642-4644. ISSN 0022-2623

Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Davies, John W, Wrigglesworth, Roger, Dunstan, Andrew R, Bloomfield, Graham C, Drake, Gillian S, McIntyre, Peter, Brown, Michael C, Burgess, Gillian M, Lee, Wai, Davis, Clare, Yaqoob, Mohammed, Phagoo, Steve B, Phillips, Elsa, Perkins, Martin N, Campbell, Elizabeth A, Davis, Andrew J and Rang, Humphrey P (2002) Nonpeptide bradykinin B2 receptor antagonists: conversion of rodent-selective bradyzide analogues into potent, orally-active human bradykinin B2 receptor antagonists. Journal of Medicinal Chemistry, 45 (11). pp. 2160-2172. ISSN 0022-2623

Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Ko, Soo Y, Wrigglesworth, Roger, Hughes, Glyn A, Dunstan, Andrew R, Bloomfield, Graham C, Drake, Gillian S, Brown, Michael C, Lee, Wai, Burgess, Gillian M, Davis, Clare, Yaqoob, Mohammed, Perkins, Martin N, Campbell, Elizabeth A, Davis, Andrew J and Rang, Humphrey P (2000) 1-(2-Nitrophenyl)thiosemicarbazides: a novel class of potent, orally active non-peptide antagonist for the Bradykinin B2 receptor. Journal of Medicinal Chemistry, 43 (5). pp. 769-771. ISSN 0022-2623

Roe, S Mark, Prodromou, Chrisostomos, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. Journal of Medicinal Chemistry, 42 (2). pp. 260-266. ISSN 0022-2623

Walpole, Christopher S J, Bevan, Stuart, Bloomfield, Graham, Breckenridge, Robin, James, Iain F, Ritchie, Timothy, Szallasi, Arpad, Winter, Janet and Wrigglesworth, Roger (1996) Similarities and differences in the structure−activity relationships of capsaicin and resiniferatoxin analogues. Journal of Medicinal Chemistry, 39 (15). pp. 2939-2952. ISSN 0022-2623

Chan, Chuen, Andreotti, Daniele, Cox, Brian, Dymock, Brian W, Hutson, Julie L, Keeling, Suzanne E, McCarthy, Alun D, Procopiou, Panayiotis A, Ross, Barry C, Sareen, Meenu, Scicinski, Jan J, Sharratt, Peter J, Snowden, Michael A and Watson, Nigel S (1996) The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. Journal of Medicinal Chemistry, 39 (1). pp. 207-216. ISSN 0022-2623

Procopiou, Panayiotis A, Cox, Brian, Kirk, Barrie E, Lester, Michael G, McCarthy, Alun D, Sareen, Meenu, Sharratt, Peter J, Snowden, Michael A, Spooner, Stephen J, Watson, Nigel S and Widdowson, Julia (1996) The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C-3 modified analogues. Journal of Medicinal Chemistry, 39 (7). pp. 1413-1422. ISSN 0022-2623