B

Becker, Jordan R, Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W, Bilham, Kirstin, Holt, Abbey B, Blackford, Andrew N, Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven and Chapman, J Ross (2018) The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity. Nature Communications, 9 (5406). pp. 1-12. ISSN 2041-1723

C

Calmels, Nadege, Botta, Elena, Jia, Nan, Fawcett, Heather, Nardo, Tiziana, Nakazawa, Yuka, Lanzafame, Manuela, Moriwaki, Shinichi, Sugita, Katsuo, Kubota, Masaya, Orbinger, Cathy, Spitz, Marie-Aude, Stefanini, Miria, Laugel, Vincent, Orioli, Donata, Ogi, Tomoo and Lehmann, Alan Robert (2018) Functional and clinical relevance of novel mutations in a large cohort of patients with Cockayne syndrome. Journal of Medical Genetics, 55 (5). pp. 329-343. ISSN 0022-2593

Cannavo, Elda, Johnson, Dominic, Andres, Sara, Kissling, Vera, Reinert, Julia, Garcia, Valerie, Erie, Dorothy, Hess, Daniel, Thomä, Nicolas, Enchev, Radoslav, Peter, Matthias, Williams, Scott, Neale, Matt and Cejka, Petr (2018) Regulatory control of DNA end resection by Sae2 phosphorylation. Nature Communications, 9. p. 4016. ISSN 2041-1723

D

Day, Matthew, Rappas, Mathieu, Ptasinska, Katie, Boos, Dominik, Oliver, Antony W and Pearl, Laurence H (2018) BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. eLife, 7 (e39979). pp. 1-18. ISSN 2050-084X

E

Evangelista, Federica M, Maglott-Roth, Anne, Stierle, Matthieu, Brino, Laurent, Soutoglou, Evi and Tora, Laszlo (2018) Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair. Journal of Cell Biology, 217 (10). pp. 3382-3397. ISSN 0021-9525

F

Fernández-Casañas, Maria and Chan, Kok-Lung (2018) The unresolved problem of DNA bridging. Genes, 9 (12). a623 1-16. ISSN 2073-4425

Fontana, Gabriele A, Reinert, Julia K, Thomä, Nicolas H and Rass, Ulrich (2018) Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks. Microbial Cell, 5 (7). pp. 327-343. ISSN 2311-2638

G

Gittens, William (2018) PARP/XRCC1 surveillance of the human genome. Doctoral thesis (PhD), University of Sussex.

H

Hanzlikova, Hana, Kalasova, Ilona, Demin, Annie A, Pennicott, Lewis E, Cihlarova, Zuzana and Caldecott, Keith W (2018) The importance of Poly(ADP-Ribose) Polymerase as a sensor of unligated Okazaki fragments during DNA replication. Molecular Cell, 71 (2). pp. 319-331. ISSN 1097-2765

L

Lemmens, Bennie, Hegarat, Nadia, Akopyan, Karen, Sala-Gaston, Joan, Bartek, Jiri, Hochegger, Helfrid and Lindqvist, Arne (2018) DNA replication determines timing of mitosis by restricting CDK1 and PLK1 activation. Molecular Cell, 71 (1). 117-128.e3. ISSN 1097-2765

Lu, Wei-Ting, Hawley, Ben R, Skalka, George L, Baldock, Robert A, Smith, Ewan M, Bader, Aldo S, Malewicz, M, Watts, Felicity Z, Wilczynska, Ania and Bushell, Martin (2018) Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair. Nature Communications, 9 (532). pp. 1-13. ISSN 2041-1723

M

Maina, Mahmoud B, Bailey, Laura J, Doherty, Aidan J and Serpell, Louise C (2018) The involvement of Aβ42 and tau in nucleolar and protein synthesis machinery dysfunction. Frontiers in Cellular Neuroscience, 12 (220). pp. 1-13. ISSN 1662-5102

Maina, Mahmoud B, Bailey, Laura J, Wagih, Sherin, Biasetti, Luca, Pollack, Saskia J, Quinn, James P, Thorpe, Julian R, Doherty, Aidan J and Serpell, Louise C (2018) The involvement of tau in nucleolar transcription and the stress response. Acta Neuropathologica Communications, 6 (70). pp. 1-13. ISSN 2051-5960

Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F, Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J Mark, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H and Llorca, Oscar (2018) Erratum to: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature Communications, 9. p. 3063. ISSN 2041-1723

Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F, Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J Mark, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H and Llorca, Oscar (2018) RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature Communications, 9 (1). ISSN 2041-1723

Mirman, Zachary, Lottersberger, Francisca, Takai, Hiroyuki, Kibe, Tatsuya, Gong, Yi, Takai, Kaori, Bianchi, Alessandro, Zimmerman, Michal, Durocher, Daniel and de Lange, Tittia (2018) 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature, 560. pp. 112-116. ISSN 0028-0836

Mok, Myth T, Zhou, Jingying, Tang, Wenshu, Zeng, Xuezhen, Oliver, Antony W, Ward, Simon E and Cheng, Alfred S L (2018) CCRK is a novel signalling hub exploitable in cancer immunotherapy. Pharmacology and Therapeutics, 186. pp. 138-151. ISSN 0163-7258

Mothersill, Carmel, Abend, Michael, Bréchignac, Francois, Copplestone, David, Geras'kin, Stanislav, Goodman, Jessica, Horemans, Nele, Jeggo, Penny, McBride, William, Mousseau, Timothy A, O'Hare, Timothy, Papineni, Rao V L, Powathil, Gibin, Schofield, Paul N, Seymour, Colin, Sutcliffe, Jill and Austin, Brian (2018) The tubercular badger and the uncertain curve:- the need for a multiple stressor approach in environmental radiation protection. Environmental Research, 168. pp. 130-140. ISSN 0013-9351

Murray, Johanne M and Carr, Antony M (2018) Integrating DNA damage repair with the cell cycle. Current Opinion in Cell Biology, 52. pp. 120-125. ISSN 0955-0674

O

Olukoga, Tomisin (2018) Investigations into the spatial distribution of γH2AX around a DNA double-strand break and the analysis of double-strand break mobility. Doctoral thesis (PhD), University of Sussex.

P

Pera Rojas, Alejandra, Caserta, Stefano, Albanese, Fabio, Blowers, Pinar, Morrow, George, Terrazzini, Nadia, Smith, Helen E, Rajkumar, Chakravarthi, Reus, Bernhard, Msonda, James R, Verboom, Murielle, Hallenensleben, Michael, Blasczyk, Rainer, Davies, Kevin A and Kern, Florian (2018) CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of Cardiovascular death. Theranostics, 8 (16). pp. 4509-4519. ISSN 1838-7640

Ptasińska, Katarzyna (Katie) (2018) Studying DNA replication dynamics in Schizosaccharomyces pombe using next generation sequencing. Doctoral thesis (PhD), University of Sussex.

R

Ramos, Eliana Marisa, Carecchio, Miryam, Lemos, Roberta, Ferreira, Joana, Legati, Andrea, Sears, Renee Louise, Hsu, Sandy Chan, Panteghini, Celeste, Magistrelli, Luca, Salsano, Ettore, Esposito, Silvia, Taroni, Franco, Richard, Anne-Claire, Tranchant, Christine, Anheim, Mathieu, Ayrignac, Xavier, Goizet, Cyril, Vidailhet, Marie, Maltete, David, Wallon, David, Frebourg, Thierry, Pimentel, Lylyan, Geschwind, Daniel H, Vanakker, Olivier, Galasko, Douglas, Fogel, Brent L, Innes, A Micheil, Ross, Alison, Dobyns, William B, Alcantara, Diana, O'Driscoll, Mark, Hannequin, Didier, Campion, Dominique, The French PBC Study group, , Oliveira, João R, Garavaglia, Barbara, Coppola, Giovanni and Nicolas, Gaël (2018) Primary brain calcification: an international study reporting novel variants and associated phenotypes. European Journal of Human Genetics, 26 (10). pp. 1462-1477. ISSN 1018-4813

Rata, Scott, Suarez Peredo Rodriguez, Maria F, Joseph, Stephy, Peter, Nisha, Echegaray Iturra, Fabio, Yang, Fengwei, Madzvamuse, Anotida, Ruppert, Jan G, Samejima, Kumiko, Platani, Melpomeni, Alvarez-Fernandez, Monica, Malumbres, Marcos, Earnshaw, William C, Novak, Bela and Hochegger, Helfrid (2018) Two interlinked bistable switches govern mitotic control in mammalian cells. Current Biology, 28 (23). 3824-3832.e6. ISSN 0960-9822

Robinson, Sophie R, Viegas, Sandra C, Matos, Rute G, Domingues, Susana, Bedir, Marisa, Stewart, Helen J S, Chevassut, Timothy, Oliver, Antony W, Arraiano, Cecilia M and Newbury, Sarah F (2018) DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers. Biochemical Journal, 475 (12). pp. 2091-2105. ISSN 0264-6021

Roe, Mark, Wahab, Ben, Torok, Zsolt, Horvath, Ibolya, Vigh, Laszlo and Prodromou, Chrisostomos (2018) Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection. Frontiers in Molecular Biosciences, 5 (51). pp. 1-14. ISSN 2296-889X

S

Shibata, Atsushi, Jeggo, Penny and Löbrich, Markus (2018) The pendulum of the Ku-Ku clock. DNA Repair, 71. pp. 164-171. ISSN 1568-7864

Silva, Joana, Aivio, Suvi, Knobel, Philip A, Bailey, Laura, Casali, Andreu, Vinaixa, Maria, Garcia-Cao, Isabel, Coyaud, Étienne, Jourdain, Alexis A, Perez-Ferreros, Pablo, Rojas, Ana M, Antolin-Fontes, Albert, Samino-Gené, Sara, Raught, Brian, González-Reyes, Acaimo, Ribas de Pouplana, Lluis, Doherty, Aidan J, Yanes, Oscar and Stracker, Travis H (2018) EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nature Cell Biology, 20. pp. 162-174. ISSN 1465-7392

Srinivasan, Madhusudhan, Scheinost, Johanna C, Petela, Naomi J, Gligoris, Thomas G, Wissler, Maria, Ogushi, Sugako, Collier, James E, Voulgaris, Menelaos, Kurze, Alexander, Chan, Kok-Lung, Hu, Bin, Constanzo, Vincenzo and Nasmyth, Kim A (2018) The cohesin ring uses its hinge to organize DNA using non-topological as well as topological mechanisms. Cell, 173 (6). pp. 1508-1519. ISSN 1097-4172

Šviković, Sasa, Crisp, Alastair, Tan-Wong, Sue Mei, Guilliam, Thomas A, Doherty, Aidan J, Proudfoot, Nicholas, Guilbaud, Guillaume and Sale, Julian (2018) R-loop formation during S phase is restricted by PrimPol-mediated repriming. The EMBO Journal, 38 (3). e99793 1-19. ISSN 0261-4189

T

Tiwari, Ankana, Addis Jones, Owen and Chan, Kok-Lung (2018) 53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process. Nature Communications, 9 (1). a677 1-17. ISSN 2041-1723

V

Vulin, Adeline, Sedkaoui, Melissa, Moratille, Sandra, Sevenet, Nicolas, Soularne, Pascal, Rigaud, Odile, Guibbal, Laure, Dulong, Joshua, Jeggo, Penny, Deleuze, Jean-François, Lamartine, Jérôme and Martin, Martin (2018) Severe PATCHED1 deficiency in cancer-prone Gorlin patient cells results in intrinsic radiosensitivity. International Journal of Radiation Oncology - Biology - Physics, 102 (2). pp. 417-425. ISSN 0360-3016

Y

Yasuda, Takeshi, Kagawa, Wataru, Ogi, Tomoo, Kato, Takamitsu A, Suzuki, Takehrio, Dohmae, Naoshi, Takisawa, Kazaya, Nakazawa, Yuka, Genet, Matthew D, Saotome, Mika, Hama, Michio, Konishi, Teruaki, Nakajima, Nakako Izumi, Hazawa, Masaharu, Tomita, Masanori, Koike, Manabu, Noshiro, Katsuko, Tomiyama, Kenichi, Obara, Chizuka, Gotoh, Takaya, Ui, Ayako, Fujimori, Akira, Nakayama, Fumiaki, Hanaoka, Fumio, Sugasawa, Kaoru, Okayasu, Ryuichi, Jeggo, Penny A and Tajima, Katsushi (2018) Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites. PLoS ONE. pp. 1-38. ISSN 1932-6203

Z

Zagnol-iVieira, Guido, Bruni, Francesco, Thompson, Kyle, He, Langping, Walker, Sarah, de Brouwer, Arjan P M, Taylor, Robert, Niyazov, Dimitriy and Caldecott, Keith W (2018) Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23). Neurology Genetics, 4 (4). ISSN 2376-7839