Items for Sussex Centre for Genome Damage and Stability in 2014

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Number of items: 42.

A

Alagoz, Meryem, Wells, Owen S and El-Khamisy, Sherif F (2014) TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Research, 42 (5). pp. 3089-3103. ISSN 0305-1048

Alcantara, Diana and O'Driscoll, Mark (2014) Congenital microcephaly. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 166 (2). pp. 124-139. ISSN 1552-4868

B

Baple, Emma L, Chambers, Helen, Cross, Harold E, Fawcett, Heather, Nakazawa, Yuka, Chioza, Barry A, Harlalka, Gaurav V, Mansour, Sahar, Sreekantan-Nair, Ajith, Patton, Michael A, Muggenthaler, Martina, Rich, Phillip, Wagner, Karin, Coblentz, Roselyn, Stein, Constance K, Last, James I, Taylor, A Malcolm R, Jackson, Andrew P, Ogi, Tomoo, Lehmann, Alan R, Green, Catherine M and Crosby, Andrew H (2014) Hypomorphic PCNA mutation underlies a novel human DNA repair disorder. Journal of Clinical Investigation, 124 (7). pp. 3137-3146. ISSN 0021-9738

Barton, Olivia, Naumann, Steffen C, Diemer-Biehs, Ronja, Kunzel, Julia, Steinlage, Monika, Conrad, Sandro, Makharashvili, Nodar, Wang, Jiadong, Feng, Lin, Lopez, Bernard S, Paull, Tanya T, Chen, Junji, Jeggo, Penny A and Löbrich, Markus (2014) Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. Journal of Cell Biology, 206 (7). pp. 877-894. ISSN 0021-9525

Baxter, Jonathan (2014) “Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines. Journal of Molecular Biology, 427 (3). pp. 590-607. ISSN 0022-2836

Brownlee, Peter M, Chambers, Anna L, Cloney, Ross, Bianchi, Alessandro and Downs, Jessica A (2014) BAF180 promotes cohesion and prevents genome instability and aneuploidy. Cell Reports, 6 (6). pp. 973-981. ISSN 2211-1247

Brownlee, Peter Moore (2014) Novel functions for the BAF180 tumour suppressor: insights from mammalian and yeast systems. Doctoral thesis (PhD), University of Sussex.

C

Carr, Antony, Lambert, Sarah A E, Tsang, Ellen, Miyabe, Izumi, Iraqui, Ismail and Zheng, Jiping (2014) The extent of error-prone replication-restart by homologous recombination is controlled by Exo1 and checkpoint proteins. Journal of Cell Science, 127 (13). pp. 2983-2994. ISSN 0021-9533

Cooper, Tim J, Wardell, Kayleigh, Garcia, Valerie and Neale, Matthew J (2014) Homeostatic regulation of meiotic DSB formation by ATM/ATR. Experimental Cell Research, 329 (1). pp. 124-131. ISSN 1090-2422

D

Dave, Anoushka, Cooley, Carol, Garg, Mansi and Bianchi, Alessandro (2014) Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity. Cell Reports, 7 (1). pp. 53-61. ISSN 2211-1247

E

Etheridge, Thomas J, Boulineau, Rémi L, Herbert, Alex, Watson, Adam T, Daigaku, Yasukazu, Tucker, Jem, George, Sophie, Jönsson, Peter, Palayret, Matthieu, Lando, David, Laue, Ernest, Osborne, Mark A, Klenerman, David, Lee, Steven F and Carr, Antony M (2014) Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy. Nucleic Acids Research, 42 (19). e146. ISSN 0305-1048

G

Garg, Mansi, Gurung, Resham L, Mansoubi, Sahar, Ahmed, Jubed O, Davé, Anoushka, Watts, Felicity Z and Bianchi, Alessandro (2014) Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association. EMBO Reports, 15 (8). pp. 871-877. ISSN 1469-3178

Gligoris, Thomas G, Scheinost, Johanna C, Bürmann, Frank, Petela, Naomi, Chan, Kok-Lung, Uluocak, Pelin, Beckouët, Frédéric, Gruber, Stephan, Nasmyth, Kim and Löwe, Jan (2014) Closing the cohesin ring: structure and function of its Smc3-kleisin interface. Science, 346 (6212). pp. 963-967. ISSN 1095-9203

Gomez Herreros, Fernando, Schuurs-Hoeijmakers, Janneke H M, McCormack, Mark, Greally, Marie T, Rulten, Stuart, Romero-Granados, Rocio, Counihan, Timothy J, Chaila, Elijah, Conroy, Judith, Ennis, Sean, Delanty, Norman, Cortes-Ledesma, Felipe, de Brouwer, Arjan P M, Cavalleri, Gianpiero L, El-Khamisy, Sherif F, de Vries, Bert B A and Caldecott, Keith (2014) TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics, 46 (5). pp. 516-524. ISSN 1061-4036

Grundy, Gabrielle J, Moulding, Hayley A, Caldecott, Keith W and Rulten, Stuart L (2014) One ring to bring them all--the role of Ku in mammalian non-homologous end joining. DNA repair, 17. pp. 30-38. ISSN 1568-7856

Gwon, Gwang Hyeon, Kim, Youngran, Liu, Yaqi, Watson, Adam, Jo, Aera, Etheridge, Thomas, Yuan, Fenghua, Zhang, Yanbin, Kim, YoungChang, Carr, Antony and Cho, Yunje (2014) Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5′ flap DNA: basis of interstrand cross-link repair by FAN1. Genes and Development, 28. pp. 2276-2290. ISSN 0890-9369

H

Hart, LesleyRuth, Rauch, Anita, Carr, Antony, Vermeesch, Joris R and O'Driscoll, Mark (2014) LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition. Disease Models and Mechanisms, 7. pp. 535-545. ISSN 1754-8403

Hegarat, Nadia, Vesely, Clare, Peter, Nisha, Oliver, Antony and Hochegger, Helfrid (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa desphorylation during mitotic exit. PLoS Genetics, 10 (2). e1004259 1. ISSN 1553-7390

Hentges, Pierre, Waller, Helen Rachel, Reis, Clara C, Ferreira, Miguel Godinho and Doherty, Aidan J (2014) Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1. Cell Reports, 9 (6). pp. 2011-2017. ISSN 2211-1247

Herbert, Alex D, Carr, Antony M and Hoffmann, Eva (2014) FindFoci: a focus detection algorithm with automated parameter training that closely matches human assignments, reduces human inconsistencies and increases speed of analysis. PLoS ONE, 9 (12). e114749. ISSN 1932-6203

J

Jongjitwimol, Jirapas, Feng, Min, Zhou, Lihong, Wilkinson, Oliver, Small, Lauren, Baldock, Robert, Taylor, Deborah L, Smith, Duncan, Bowler, Lucas, Morley, Simon J and Watts, Felicity (2014) The S. pombe translation initiation factor eIF4G is sumoylated and associates with the SUMO protease Ulp2. PLoS ONE, 9 (5). e94182. ISSN 1932-6203

K

Kakarougkas, A and Jeggo, P A (2014) DNA DSB repair pathway choice: an orchestrated handover mechanism. British Journal of Radiology, 87 (1035). p. 20130685. ISSN 0007-1285

Kakarougkas, Andreas, Ismail, Amani, Chambers, Anna, Riballo, Queti, Herbert, Alex, Kunzel, Julia, Lobrich, Markus, Jeggo, Penny and Downs, Jessica (2014) Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular Cell, 55 (5). pp. 723-732. ISSN 1097-2765

Keen, Benjamin A, Bailey, Laura, Jozwiakowski, Stanislaw and Doherty, Aidan J (2014) Human PrimPol mutation associated with high myopia has a DNA replication defect. Nucleic Acids Research, 42 (19). pp. 12102-12111. ISSN 0305-1048

Keen, Benjamin A, Jozwiakowski, Stanislaw K, Bailey, Laura J, Bianchi, Julie and Doherty, Aidan J (2014) Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Nucleic Acids Research, 42 (9). pp. 5830-5845. ISSN 0305-1048

Kuron, Aneta, Korycka-Machala, Malgorzata, Brzostek, Anna, Nowosielski, Marcin, Doherty, Aidan, Dziadek, Bożena and Dziadek, Jaroslaw (2014) Evaluation of DNA primase DnaG as a potential target for antibiotics. Antimicrobial Agents and Chemotherapy, 58 (3). pp. 1699-1706. ISSN 1098-6596

Kustatscher, Georg, Hégarat, Nadia, Willis, Karen L H, Furlan, Cristina, Bukowski-Wills, Jimi-Carlo, Hochegger, Helfrid and Rappsilber, Juri (2014) Proteomics of a fuzzy organelle: interphase chromatin. The EMBO Journal, 33 (6). pp. 648-664. ISSN 0261-4189

M

Mirzaa, Ghyada M, Vitre, Benjamin, Carpenter, Gillian, Abramowicz, Iga, Gleeson, Joseph G, Paciorkowski, Alex R, Cleveland, Don W., Dobyns, William B and O'Driscoll, Mark (2014) Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Human Genetics, 133 (8). pp. 1023-1039. ISSN 0340-6717

P

Pal, Mohinder, Morgan, Marc, Phelps, Sarah E L, Roe, S Mark, Parry-Morris, Sarah, Downs, Jessica, Polier, Sigrun, Pearl, Laurence and Prodromou, Chrisostomos (2014) Structural basis for phosphorylation-dependent recruitment of tel2 to hsp90 by pih1. Structure, 22 (6). pp. 805-818. ISSN 1878-4186

Payne, Felicity, Colnaghi, Rita, Rocha, Nuno, Seth, Asha, Harris, Julie, Carpenter, Gillian, Bottomley, William E, Wheeler, Eleanor, Wong, Stephen, Saudek, Vladimir, Savage, David, O'Rahilly, Stephen, Carel, Jean-Claude, Barroso, Inês, O'Driscoll, Mark and Semple, Robert (2014) Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance. The Journal of Clinical Investigation, 124 (9). pp. 4028-4038. ISSN 0021-9738

Q

Qiao, Ying, Mondal, Kajari, Trapani, Valentina, Wen, Jiadi, Carpenter, Gillian, Wildin, Robert, Price, E Magda, Gibbons, Richard J, Eichmeyer, Jennifer, Jiang, Ruby, Dupont, Barbara, Martell, Sally, Lewis, Suzanne M E, Robinson, Wendy P, O'Driscoll, Mark, Wolf, Federica I, Zwick, Michael E and Rajcan-Separovic, Evica (2014) Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes. Human mutation, 35 (1). pp. 58-62. ISSN 1098-1004

R

Rasheduzzaman, Chowdhury, Brissett, Nigel, Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S, Clifton, Ian J, Ge, Wei, Kershaw, Nadia J, Fox, Gavin C, Muniz, Joao R C, Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S, Kavanagh, Kathryn L, von Delft, Frank, Oppermann, Udo, McDonough, Michael A, Doherty, Aidan and Schofield, Christopher J (2014) Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510 (7505). pp. 422-426. ISSN 0028-0836

S

Saha, Shreya, Woodbine, Lisa, Haines, Jacqueline, Coster, Margaret, Ricket, Nicole, Barazzuol, Lara, Ainsbury, Elizabeth, Sienkiewicz, Zenon and Jeggo, Penny (2014) Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields. Journal of the Royal Society Interface, 11 (100). p. 20140783. ISSN 1742-5689

Shibata, Atsushi, Moiani, Davide, Arvai, Andrew S, Perry, Jefferson, Harding, Shane M, Genois, Marie-Michelle, Maity, Ranjan, van Rossum-Fikkert, Sari, Kertokalio, Aryandi, Romoli, Filipo, Ismail, Amani, Ismalaj, Ermal, Petricci, Elena, Neale, Matthew J, Bristow, Robert G, Masson, Jean-Yves, Wyman, Claire, Jeggo, Penny and Tainer, John A (2014) DNA double-strand break repair pathway shoice is directed by distinct MRE11 nuclease activities. Molecular Cell, 53 (1). pp. 7-18. ISSN 1097-2765

V

Vejrup-Hansen, Rasmus, Fleck, Oliver, Landvad, Katrine, Fahnøe, Ulrik, Broendum, Sebastian S, Schreurs, Ann-Sofie, Kragelund, Birthe B, Carr, Antony M, Holmberg, Christian and Nielsen, Olaf (2014) Spd2 assists Spd1 in modulation of RNR architecture but does not regulate deoxynucleotide pools. Journal of Cell Science, 127. pp. 2460-2470. ISSN 0021-9533

W

Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A, Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H, Pearl, Laurence H, Oliver, Antony W, El-Khamisy, Sherif, Ward, Simon and Atack, John R (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry, 454. pp. 17-22. ISSN 0003-2697

Wardlaw, Christopher P, Carr, Antony M and Oliver, Antony W (2014) TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways. DNA Repair, 22. pp. 165-174. ISSN 1568-7864

Watts, Felicity Z, Baldock, Robert, Jongjitwimol, Jirapas and Morley, Simon J (2014) Weighing up the possibilities: controlling translation by ubiquitylation and sumoylation. Translation, 2 (2). e959366-1. ISSN 2169-074X

Wells, Owen Spencer and El-Khamisy, Sherif F (2014) Autosomal recessive ataxias due to defects in DNA repair. In: LeDoux, Mark S (ed.) Movement Disorders, 2nd Edition. Elsevier, London. ISBN 9780124051959

Woodbine, Lisa, Gennery, Andrew R and Jeggo, Penny A (2014) Reprint of “The clinical impact of deficiency in DNA non-homologousend-joining”. DNA Repair, 17. pp. 9-20. ISSN 1568-7864

Z

Zheng, Christina L, Wang, Nicholas J, Chung, Jongsuk, Moslehi, Homayoun, Sanborn, J Zachary, Hur, Joseph S, Collison, Eric A, Vemula, Swapna S, Naujokas, Agne, Chiotti, Kami E, Cheng, Jeffrey B, Fassihi, Hiva, Blumberg, Andrew J, Bailey, Celeste V, Fudem, Gary M, Mihm, Frederick G, Cunningham, Bati B, Neuhaus, Isaac M, Liao, Wilson, Oh, Dennis H, Cleaver, James E, LeBoit, Philip E, Costello, Joseph F, Lehmann, Alan, Gray, Joe W, Spellman, Paul T, Aaron, Sarah T, Huh, Nam, Purdom, Elizabeth and Cho, Raymond J (2014) Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. Cell Reports, 9 (4). pp. 1228-1234. ISSN 2211-1247

Zheng, Yupeng, Tipton, Jeremiah D, Thomas, Paul M, Kelleher, Neil L and Sweet, Steve M M (2014) Site-specific human histone H3 methylation stability: fast K4me3 turnover. Proteomics, 14 (19). pp. 2190-2199. ISSN 1615-9853

This list was generated on Mon Oct 21 13:15:30 2019 BST.