A

Argunhan, Bilge, Farmer, Sarah, Leung, Wing-Kit, Terentyev, Yaroslav, Humphryes, Neil, Tsubouchi, Tomomi, Toyoizumi, Hiroshi and Tsubouchi, Hideo (2013) Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast. PLoS ONE, 8 (6). ISSN 1932-6203

B

Bartlett, Edward, Brissett, Nigel C and Doherty, Aidan J (2013) Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proceedings of the National Academy of Sciences, 110 (22). E1984-E1991. ISSN 1091-6490

Bianchi, Julie, Rudd, Sean G, Jozwiakowski, Stanislaw K, Bailey, Laura J, Soura, Violetta, Taylor, Elaine, Stevanovic, Irena, Green, Andrew J, Stracker, Travis H, Lindsay, Howard D and Doherty, Aidan J (2013) PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Molecular Cell, 52 (4). pp. 566-573. ISSN 1097-2765

Brissett, Nigel C, Martin, Maria J, Bartlett, Edward J, Bianchi, Julie, Blanco, Luis and Doherty, Aidan J (2013) Molecular basis for DNA double-strand break annealing and primer extension by a NHEJ DNA polymerase. Cell Reports, 5 (4). pp. 1108-1120. ISSN 2211-1247

C

Carballo, Jesús A, Panizza, Silvia, Serrentino, Maria Elisabetta, Johnson, Anthony L, Geymonat, Marco, Borde, Valérie, Klein, Franz and Cha, Rita S (2013) Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery. PLoS Genetics, 9 (6). e1003545. ISSN 1553-7390

Carr, Antony, Wang, Zhao-Qi, WooKee, Min, Krueger, Anja, Bruhn, Christopher, Li, Tang-Liang, Liu, Cong and Zhou, Zhong-Wei (2013) An essential function for the ATR-Activation-Domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genetics, 9 (8). e1003702. ISSN 1553-7390

Chambers, Anna L, Pearl, Laurence H, Oliver, Antony W and Downs, Jessica A (2013) The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic Acids Research, 41 (19). pp. 9168-9182. ISSN 0305-1048

Copsey, Alice, Tang, Shangming, Jordan, Philip W, Blitzblau, Hannah, Newcombe, Sonya, Chan, Andrew Chi-ho, Newnham, Louise, Li, Zhaobo, Gray, Steve, Herbert, Alex, Arumugam, Prakash, Hochwagen, Andreas, Hunter, Neil and Hoffmann, Eva (2013) Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic division. PLoS Genetics, 9 (12). e1004071. ISSN 1553-7390

D

Dyment, David A, Smith, Amanda C, Alcantara, Diana, Schwartzentruber, Jeremy A, Basel-Vanagaite, Lina, Curry, Cynthia J, Temple, I Karen, Reardon, William, Mansour, Sahar, Haq, Mushfequr R, Gilbert, Rodney, Lehmann, Ordan J, Vanstone, Megan R, Beaulieu, Chandree L, FORGE Canada Consortium, , Majewski, Jacek, Bulman, Dennis E, O'Driscoll, Mark, Boycott, Kym M and Inness, A Micheil (2013) Mutations in PIK3R1 cause SHORT syndrome. American Journal of Human Genetics, 93 (1). pp. 158-166. ISSN 0002-9297

Dziadkowiec, D, Kramarz, K, Kanik, K, Wisniewski, P and Carr, A M (2013) Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition. Nucleic Acids Research, 41 (17). pp. 8196-8209. ISSN 0305-1048

F

Fontebasso, Y, Etheridge, T J, Oliver, A W, Murray, J M and Carr, A M (2013) The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. DNA Repair, 12 (12). pp. 1011-1023. ISSN 15687864

G

Gray, Stephen, Allison, Rachal M, Garcia, Valerie, Goldman, Alastair S H and Neale, Matthew J (2013) Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR). Open Biology, 3 (7). p. 130019. ISSN 2046-2441

Grundy, Gabrielle L, Rulten, Stuart L, Zeng, Zhihong, Arribas-Bosacoma, Raquel, Iles, Natasha, Manley, Katie, Oliver, Antony and Caldecott, Keith W (2013) APLF promotes the assembly and activity of non-homologous end joining protein complexes. The EMBO journal, 32 (1). pp. 112-125. ISSN 1460-2075

H

Hart, Lesley and O'Driscoll, Mark (2013) Causes and consequences of structural genomic alterations in the human genome. Encyclopedia of Life Sciences. pp. 1-10.

Hart, Lesley Ruth (2013) Dissecting the genotype to phenotype relationships of genomic disorders. Doctoral thesis (PhD), University of Sussex.

Humphryes, Neil, Leung, Wing-Kit, Argunhan, Bilge, Terentyev, Yaroslav, Dvorackova, Martina and Tsubouchi, Hideo (2013) The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. PLoS Genetics, 9 (1). e1003194. ISSN 1553-7390

K

Kakarougkas, Andreas, Ismail, Amani, Katsuki, Yoko, Freire, Raimundo, Shibata, Atsushi and Jeggo, Penny A (2013) Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Research, 41 (22). pp. 10298-10311. ISSN 0305-1048

Kakarougkas, Andreas, Ismail, Amani, Klement, Karolin, Goodarzi, Aaron A, Conrad, Sandro, Freire, Raimundo, Shibata, Atsushi, Lobrich, Markus and Jeggo, Penny A (2013) Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Research, 41 (21). pp. 9719-9731. ISSN 0305-1048

Keith, Brian J, Jozwiakowski, Stanislaw K and Connolly, Bernard A (2013) A plasmid-based lacZα gene assay for DNA polymerase fidelity measurement. Analytical Biochemistry, 433 (2). pp. 153-161. ISSN 0003-2697

Kerzendorfer, Claudia, Colnaghi, Rita, Abramowicz, Iga, Carpenter, Gillian and O'Driscoll, Mark (2013) Meier–Gorlin syndrome and Wolf–Hirschhorn syndrome: two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis. DNA Repair, 12 (8). pp. 637-644. ISSN 1568-7864

L

Lambert, Sarah and Carr, Antony M (2013) Impediments to replication fork movement: stabilisation, reactivation and genome instability. Chromosoma, 122 (1-2). pp. 33-45. ISSN 0009-5915

Lambert, Sarah and Carr, Antony M (2013) Replication stress and genome rearrangements: lessons from yeast models. Current Opinion in Genetics and Development, 23 (2). pp. 132-139. ISSN 0959-437X

Lee, Pamela P, Woodbine, Lisa, Gilmour, Kimberly C, Bibi, Shahnaz, Cale, Catherine M, Amrolia, Persios J, Veys, Paul A, Davies, E Graham, Jeggo, Penny A and Jones, Alison (2013) The many faces of Artemis-deficient combined immunodeficiency — two patients with DCLRE1C mutations and a systematic literature review of genotype–phenotype correlation. Clinical Immunology, 149 (3B). pp. 464-474. ISSN 1521-6616

Little, Mark P, Goodhead, Dudley T, Bridges, Bryn A and Bouffler, Simon D (2013) Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents. Mutation Research/Reviews in Mutation Research, 753 (1). pp. 50-67. ISSN 1383-5742

M

McDonell, Laura M, Mirzaa, Ghayda M, Alcantara, Diana, Schwartzentruber, Jeremy, Carter, Melissa T, Lee, Leo J, Clericuzio, Carol L, Graham, John M, Morris-Rosendahl, Deborah J, Polster, Tilman, Acsadi, Gyula, Townshend, Sharron, Williams, Simon, Halbert, Anne, Isidor, Bertrand, David, Albert, Smyser, Christopher D, Paciorkowski, Alex R, Willing, Marcia, Woulfe, John, Das, Soma, Beaulieu, Chandree L, Marcadier, Janet, FORGE Canada Consortium, , Geraghty, Michael T, Frey, Brendan J, Majewski, Jacek, Bulman, Dennis E, Dobyns, William B, O'Driscoll, Mark and Boycott, Kym M (2013) Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. Nature genetics, 45 (5). pp. 556-562. ISSN 1546-1718

Mizuno, Ken'ichi, Miyabe, Izumi, Schalbetter, Stephanie, Carr, Antony and Murray, Johanne (2013) Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature, 493. pp. 246-249. ISSN 0028-0836

Mizuno, Ken'ichi, Miyabe, Izumi, Schalbetter, Stephanie A, Carr, Antony M and Murray, Johanne M (2013) Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature, 493 (7431). pp. 246-249. ISSN 0028-0836

N

Newnham, Louise, Jordan, Philip W, Carballo, Jesus A, Newcombe, Sonya and Hoffmann, Eva (2013) Ipl1/aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis. PLoS ONE, 8 (12). e83982. ISSN 1932-6203

O

O'Driscoll, Mark (2013) INK4a/ARF-dependent senescence upon persistent replication stress. Cell Cycle, 12 (13). pp. 1997-1998. ISSN 1538-4101

P

Peters, Nicholas E, Ferguson, Brian J, Mazzon, Michela, Fahy, Aodhnait S, Krysztofinska, Ewelina, Arribas-Bosacoma, Raquel, Pearl, Laurence H, Ren, Hongwei and Smith, Geoffrey L (2013) A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus. PLoS Pathogens, 9 (10). e1003649. ISSN 1553-7374

Polier, Sigrun, Samant, Rahul S, Clarke, Paul A, Workman, Paul, Prodromou, Chrisostomos and Pearl, Laurence H (2013) ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nature Chemical Biology, 9 (5). pp. 307-312. ISSN 1552-4450

Polier, Sigrun, Samant, Rahul S, Clarke, Paul A, Workman, Paul, Prodromou, Chrisostomos and Pearl, Laurence H (2013) Erratum: ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system (Nature Chemical Biology (2013) 9 (307-312)). Nature Chemical Biology, 9. p. 406. ISSN 1552-4450

Q

Qu, Meng, Rappas, Mathieu, Wardlaw, Christopher P, Garcia, Valerie, Ren, Jing-Yi, Day, Matthew, Carr, Antony M, Oliver, Antony, Du, Li-Lin and Pearl, Laurence (2013) Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1. Molecular Cell, 51 (6). pp. 723-736. ISSN 1097-2765

R

Rass, Ulrich (2013) Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes. Chromosoma, 122 (6). pp. 499-515. ISSN 0009-5915

Rudd, Sean G, Glover, Lucy, Jozwiakowski, Stanislaw K, Horn, David and Doherty, Aidan J (2013) PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome. Molecular Cell, 52 (4). pp. 554-565. ISSN 1097-2765

Rulten, Stuart L and Caldecott, Keith W (2013) DNA strand break repair and neurodegeneration. DNA repair, 12 (8). pp. 558-567. ISSN 1568-7856

S

Sethi, Mieran, Lehmann, Alan R and Fassih, Hiva (2013) Xeroderma pigmentosum: a multidisciplinary approach. European Medical Journal Dermatol. pp. 54-63. ISSN 1472-0213

Shi, Tianlai, Bunker, Richard D, Mattarocci, Stefano, Ribeyre, Cyril, Faty, Mahamadou, Gut, Heinz, Scrima, Andrea, Rass, Ulrich, Rubin, Seth M, Shore, David and Thomä, Nicolas H (2013) Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions. Cell, 153 (6). pp. 1340-1353. ISSN 0092-8674

Silva-Santisteban, M Cris, Westwood, Isaac M, Boxall, Kathy, Brown, Nathan, Peacock, Sam, McAndrew, Craig, Barrie, Elaine, Richards, Meirion, Mirza, Amin, Oliver, Antony W, Burke, Rosemary, Hoelder, Swen, Jones, Keith, Aherne, G Wynne, Blagg, Julian, Collins, Ian, Garrett, Michelle D and van Montfort, Rob L M (2013) Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. PLoS ONE, 8 (6). e65689. ISSN 1932-6203

Stiff, Tom, Alagoz, Meryem, Alcantara, Diana, Outwin, Emily, Brunner, Han G, Bongers, Ernie M H F, O'Driscoll, Mark and Jeggo, Penny A (2013) Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of meier-gorlin syndrome. PLoS Genetics, 9 (3). e1003360. ISSN 1553-7404

V

Venkatraman Girija, Umakhanth, Gingras, Alexandre R, Marshall, Jamie E, Panchal, Roshni, Sheikh, Md Arif, Gál, Péter, Schwaeble, Wilhelm J, Mitchell, Daniel A, Moody, Peter C E and Wallis, Russell (2013) Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proceedings of the National Academy of Sciences, 110 (34). pp. 13916-13920. ISSN 0027-8424

Vesely, Clare (2013) Investigation of the mechanisms of the G2/M phase transition in human cells – the role of Greatwall kinase. Doctoral thesis (PhD), University of Sussex.

W

Watson, Adam T, Daigaku, Yasukazu, Mohebi, Saed, Etheridge, Thomas, Chahwan, Charley, Murray, Johanne M and Carr, Antony M (2013) Optimisation of the Schizosaccharomyces pombe urg1 expression system. PLoS ONE, 8 (12). e83800. ISSN 1932-6203

Watts, Felicity Z (2013) Starting and stopping SUMOylation. What regulates the regulator? Chromosoma, 122 (6). pp. 451-463. ISSN 0009-5915

Woodbine, Lisa, Neal, Jessica A, Sasi, Nanda-Kumar, Shimada, Mayuko, Deem, Karen, Coleman, Helen, Dobyns, William B, Ogi, Tomoo, Meek, Katheryn, Davies, E Graham and Jeggo, Penny A (2013) PRKDC mutations in a SCID patient with profound neurological abnormalities. Journal of Clinical Investigation, 123 (7). pp. 2969-2980. ISSN 0021-9738