Items for Sussex Centre for Genome Damage and Stability in 2009

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Number of items: 78.

A

Ali, Ammar A. E., Jukes, Rachel M., Pearl, Laurence H. and Oliver, Antony W. (2009) Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. Nucleic Acids Research, 37 (5). pp. 1701-1712. ISSN 0305-1048

B

Barrett, Rachel M.A., Osborne, Toby P. and Wheatley, Sally P. (2009) Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity. Cell Cycle, 8 (2). pp. 278-283. ISSN 1538-4101

Beucher, Andrea, Birraux, Julie, Tchouandong, Leopoldine, Barton, Olivia, Shibata, Atsushi, Conrad, Sandro, Goodarzi, Aaron A, Krempler, Andrea, Jeggo, Penny and Lo¨brich, Markus (2009) ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO Journal, 28 (21). pp. 3413-3427. ISSN 0261-4189

Breslin, Claire and Caldecott, Keith W (2009) DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress. Molecular and Cellular Biology, 29 (17). pp. 4653-4662. ISSN 0270-7306

Brissett, Nigel C and Doherty, Aidan J (2009) Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway. In: Symposium on DNA Damage - From Causes to Cures, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND, DEC 15-17, 2008.

Brown, Stephanie, Niimi, Atsuko and Lehmann, Alan R (2009) Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork. Cell Cycle, 8 (5). pp. 689-692. ISSN 1538-4101

Bunney, Tom D, Opaleye, Olanivi, Roe, S Mark, Vatter, Petra, Baxendale, Rhona W, Walliser, Claudia, Everett, Katy L, Josephs, Michelle B, Christow, Carolin, Rodrigues-Lima, Fernando, Gierschik, Peter, Pearl, Laurence H and Katan, Matilda (2009) Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Molecular Cell, 34 (2). pp. 223-233. ISSN 1097-2765

C

Chalmers, Anthony J (2009) The potential role and application of PARP inhibitors in cancer treatment. British Medical Bulletin, 89 (1). pp. 23-40. ISSN 0007-1420

Chalmers, Anthony J, Ruff, Elliot M, Martindale, Christine, Lovegrove, Nadia and Short, Susan C (2009) Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent. International Journal of Radiation: Oncology - Biology - Physics, 75 (5). pp. 1511-1519. ISSN 0360-3016

Chan, Andrew Chi-ho, Borts, Rhona H and Hoffmann, Eva (2009) Temperature-dependent modulation of interference and chromosome segregation in msh4 mutants of budding yeast. PLoS ONE, 4. e7284. ISSN 1932-6203

Chi, Peter, Kwon, Youngho, Moses, Dana N, Seong, Changyun, Singh, Akhilesh K, Tsubouchi, Hideo, Greene, Eric C, Klein, Hannah L and Sung, Patrick (2009) Functional interactions of meiotic recombination factors Rdh54 and Dmc1. DNA Repair, 8 (2). pp. 279-284. ISSN 1568-7864

Clyne, M, Offman, J, Shanley, S, Virgo, J D, Radulovic, M, Wang, Y, Ardern-Jones, A, Eeles, R, Hoffman, E, Yu, V P C C and Unset (2009) The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome. British Journal of Cancer, 100. pp. 376-380. ISSN 0007-0920

Cortes Ledesma, Felipe, El-Khamisy, Sherif F, Zuma, Maria C, Osborn, Kay and Caldecott, Keith W (2009) A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature, 461 (7264). pp. 674-678. ISSN 0028-0836

Covo, Shay, de Villartay, Jean-Pierre, Jeggo, Penny A and Livneh, Zvi (2009) Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Research, 37 (20). pp. 6737-6745. ISSN 0305-1048

D

Doré, Andrew S, Kilkenny, Mairi L, Rzechorzek, Neil J and Pearl, Laurence H (2009) Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex¿Implications for Clamp Loading and Regulation. Molecular Cell, 34 (6). pp. 735-745. ISSN 1097-2765

Dungey, Fiona A, Caldecott, Keith W and Chalmers, Anthony J (2009) Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics, 8 (8). pp. 2243-2254. ISSN 1535-7163

Dungey, Fiona A, Caldecott, Keith W and Chalmers, Anthony J (2009) Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics, 8 (8). pp. 2243-2254. ISSN 1535-7163

Dziadkowiec, Dorota, Petters, Edyta, Dyjankiewicz, Agnieszka, Karpinski, Pawel, Garcia, Valerie, Watson, Adam T. and Carr, Antony M. (2009) The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomycespombe. DNA Repair, 8 (5). pp. 627-636. ISSN 1568-7864

Dziadkowiec, Dorota, Petters, Edyta, Dyjankiewicz, Agnieszka, Karpiński, Pawel, Garcia, Valerie, Watson, Adam and Carr, Antony M (2009) The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe. DNA Repair, 8 (5). pp. 627-636. ISSN 1568-7864

E

El-Khamisy, Sherif F, Katyal, Sachin, Patel, Poorvi, Ju, Limei, McKinnon, Peter J and Caldecott, Keith W (2009) Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair, 8 (6). pp. 760-766. ISSN 1568-7864

Eliezer, Yifat, Argaman, Liron, Rhie, Alexandre, Doherty, Aidan J and Goldberg, Michal (2009) The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. Journal of Biological Chemistry, 284 (1). pp. 426-435. ISSN 0021-9258

F

Forsythe, Elizabeth, Wild, Ruth, Sellick, Gabrielle, Houlston, Richard S., Lehmann, Alan R and Wakeling, Emma (2009) A Novel DNA Repair Disorder With Thrombocytopenia, Nephrosis, and Features Overlapping Cockayne Syndrome. American Journal of Medical Genetics Part A, 149A (10). pp. 2075-2079. ISSN 1552-4825

Forsythe, Elizabeth, Wild, Ruth, Sellick, Gabrielle, Houlston, Richard S., Lehmann, Alan R. and Wakeling, Emma (2009) A novel DNA repair disorder with thrombocytopenia, nephrosis and features overlapping Cockayne syndrome. American Journal of Medical Genetics Part A, 149A (10). pp. 2075-2079. ISSN 1552-4825

Foster, Elinor R and Downs, Jessica A (2009) Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. Journal of Cell Biology, 184 (5). pp. 631-638. ISSN 0021-9525

G

Goodarzi, Aaron A, Noon, Angela T and Jeggo, Penny A (2009) The impact of heterochromatin on DSB repair. Biochemical Society Transactions, 37 (3). pp. 569-576. ISSN 03005127

Goodarzi, Aaron A, Noon, Angela T and Jeggo, Penny A (2009) The impact of heterochromatin on DSB repair. Biochemical Society Transactions, 37 (3). pp. 569-576. ISSN 0300-5127

H

Hartsuiker, Edgar, Mizuno, Kenichi, Molnar, Monika, Kohli, Juerg, Ohta, Kunihiro and Carr, Antony M (2009) Ctp1(CtIP) and Rad32(Mre11) nuclease activity are required for Rec12(Spo11) removal, but Rec12(Spo11) removal Is dispensable for other MRN-Dependent meiotic functions. Molecular and Cellular Biology, 29 (7). pp. 1671-1681. ISSN 0270-7306

Hartsuiker, Edgar, Neale, Matthew J and Carr, Antony M (2009) DistinctrRequirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound Topoisomerase I and II from DNA. Molecular Cell, 33 (1). pp. 117-123. ISSN 1097-2765

Hishida, T, Kubota, Y, Carr, Antony M and Iwasaki, H (2009) RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature, 457 (7229). pp. 612-615. ISSN 0028-0836

Hishida, Takashi, Kubota, Yoshino, Carr, Antony M and Iwasaki, Hiroshi (2009) RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature, 457. pp. 612-615. ISSN 0028-0836

Hoffmann, Eva, Victoria, C, Rhona, B and Faiz, A (2009) The devil is in the details: The importance of genetic and environmental factors for yeast meiosis. In: Protocols for Meiosis. Unset.

I

Irmisch, Anja, Ampatzidou, Eleni, Mizuno, Ken'ichi, O'Connell, Matthew J and Murray, Johanne M (2009) Smc5/6 maintains stalled replication forks in a recombination-competent conformation. EMBO Journal, 28 (2). pp. 144-155. ISSN 0261-4189

J

Jahan, Nasrin, Potter, Jane A, Sheikh, Md Arif, Botting, Catherine H, Shirran, Sally L, Westwood, Nicholas J and Taylor, Garry L (2009) Insights into the biosynthesis of the Vibrio cholerae major autoinducer CAI-1 from the crystal structure of the PLP-dependent enzyme CqsA. Journal of Molecular Biology, 392 (3). pp. 763-773. ISSN 0022-2836

Jeggo, Peggy A. (2009) Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health Physics, 97 (5). pp. 416-425. ISSN 0017-9078

Jeggo, Penny (2009) Mechanisms conferring sensitivity to low dose radiation exposure and consideration of potentially sensitivie individuals. In: Late health effects of ionizing radiation: bridging the experimental and epidemiological divide, 4-6 May 2009, Georgetown University, Washington D.C..

Jeggo, Penny and Lavin, Martin F (2009) Cellular Radiosensitivity: How much better do we understand it? International Journal of Radiation Biology, 85 (12). pp. 1061-1081. ISSN 0955-3002

Jordan, P, Copsey, A, Newnham, L, Kolar, E, Lichten, M. and Hoffmann, Eva (2009) Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes and Development, 23. pp. 2237-2251. ISSN 0890-9369

Jordan, Philip, Copsey, Alice, Newnham, Louise, Kolar, E., Lichten, M. and Hoffmann, Eva (2009) Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes and Development, 23 (18). pp. 2237-2251. ISSN 0890-9369

Jordan, Philip, Copsey, Alice, Newnham, Louise, Kolar, Eizabeth, Michael, Lichten and Hoffmann, Eva (2009) Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes and Development, 23 (18). pp. 2237-2251. ISSN 0890-9369

Jozwiakowski, Stanislaw and Connolly, BA (2009) Plasmid-based lacZalpha assay for DNA polymerase fidelity: application to archaeal family-B DNA polymerase. Nucleic Acids Research, 37 (15). e102. ISSN 0305-1048

K

Kerzendorfer, Claudia and O'Driscoll, Mark (2009) Human DNA damage response & repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency. DNA Repair, 8 (9). pp. 1139-1152.

Kerzendorfer, Claudia and O'Driscoll, Mark (2009) UVB and caffeine: inhibiting the DNA damage response to protect against the adverse effects of UVB. Journal of Investigative Dermatology, 129 (7). pp. 1611-1613. ISSN 0022-202X

L

Lee, Youngsoo, Katyal, Sachin, Li, Yang, El-Khamisy, Sherif F, Russell, Helen R, Caldecott, Keith W and McKinnon, Peter J (2009) The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nature Neuroscience, 12 (8). 973-U35. ISSN 1097-6256

Lehmann, Alan R (2009) DNA damage tolerance and translesions synthesis. In: Khanna, Kum Kum and Shiloh, Yosef (eds.) The DNA damage response: implications on cancer formation and treatment. Springer, Dordrecht, pp. 209-234. ISBN 9789048125609

Lehmann, Alan R. (2009) DNA Damage Tolerance and Translesion Synthesis (Chapter 10). In: Khanna, Kum Kum and Shiloh, Yosef (eds.) The DNA Damage Response: Implications on Cancer Formation and Treatment. Springer Science+Business Media B.V. 2009, pp. 209-234. ISBN 9789048125609

Limsirichaikul, Siripan, Niimi, Atsuko, Fawcett, Heather, Lehmann, Alan, Yamashita, Shunichi and Ogi, Tomoo (2009) A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of Ethynyl deoxyuridine (EdU). Nucleic Acids Research, 37 (4). ISSN 0305-1048

Lloyd, Janette, Chapman, J. Ross, Clapperton, Julie A., Haire, Lesley F., Hartsuiker, Edgar, Li, Jiejin, Carr, Antony M., Jackson, Stephen P. and Smerdon, Stephen J. (2009) A supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell, 139 (1). pp. 100-111. ISSN 0092-8674

M

Mayer, Matthias P, Prodromou, Chrisostomos and Frydman, Judith (2009) The Hsp90 mosaic: a picture emerges. Nature Structural and Molecular Biology, 16 (1). pp. 2-6. ISSN 1545-9993

Miyabe, Izumi, Morishita, Takashi, Shinagawa, Hideo and Carr, Antony M (2009) Schizosaccharomyces pombe Cds1 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60. Journal of Cell Science, 122. pp. 3638-3643. ISSN 0021-9533

Miyabe, Izumi, Morishita, Takashi, Shinagawa, Hideo and Carr, Antony M (2009) Schizosaccharomyces pombe Cds1(Chk2) regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60. Journal of Cell Science, 122 (20). pp. 3638-3643. ISSN 0021-9533

Mizuno, Ken'ichi, Lambert, Sarah, Baldacci, Giuseppe, Murray, Johanne M and Carr, Antony M (2009) Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism. Genes and Development, 23 (24). pp. 2876-2886. ISSN 0890-9369

N

Neale, Matt and Keeney, S (2009) End-labeling and analysis of Spo11-oligonucleotide complexes in Saccharomyces cerevisiae. Methods in Molecular Biology, 557. pp. 183-195. ISSN 10643745

Nijnik, Anastasia, Dawson, Sara, Woodbine, Lisa, Visetnoi, Supawan, Bennett, Sophia, Jones, Margaret, Turner, Gareth D, Jeggo, Penelope A, Goodnow, Christopher C and Cornall, Richard J (2009) Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. Journal of Clinical Investigation, 119 (6). pp. 1696-1705. ISSN 00219738

Nilapwar, Sanjay, Williams, Eleanor, Fu, Christopher, Prodromou, Chrisostomos, Pearl, Laurence H, Williams, Mark A and Ladbury, John E (2009) Structural–Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90. Journal of Molecular Biology, 392 (4). pp. 923-936. ISSN 0022-2836

O

O'Driscoll, Mark (2009) Defects in the ATR-dependent DNA damage response pathway and human syndromes. Acta Medica Nagasakiensia, 53. S23-S30. ISSN 0001-6055

O'Driscoll, Mark (2009) Life can be stressful without ATR. Nature Genetics, 41 (8). pp. 866-868. ISSN 1061-4036

O'Driscoll, Mark (2009) Life can be stressful without ATR. Nature Genetics, 41 (8). pp. 866-888. ISSN 10614036

O'Driscoll, Mark (2009) Mouse models for ATR deficiency. DNA Repair, 8 (11). pp. 1333-1337. ISSN 1568-7864

O'Driscoll, Mark and Jeggo, Penny (2009) Introduction to the DNA repair and methylation defects. In: Primary Immunodeficiency Diseases. A Molecular and Genetic Approach. Oxford University Press.

Oliver, Antony W, Swift, Sally, Lord, Christopher J, Ashworth, Alan and Pearl, Laurence H (2009) Structural basis for recruitment of BRCA2 by PALB2. EMBO Reports, 10 (9). pp. 990-996. ISSN 1469-221X

Outwin, Emily A, Irmisch, Anja, Murray, Johanne M and O'Connell, Matthew J (2009) Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes. Molecular and Cellular Biology, 29 (16). pp. 4363-4375. ISSN 0270-7306

P

Prodromou, Chrisostomos (2009) Strategies for Stalling Malignancy: Targeting Cancer's Addiction to Hsp90. Current Topics in Medicinal Chemistry, 9 (15). pp. 1352-1368. ISSN 1568-0266

Prodromou, Chrisostomos, Nuttall, James M, Millson, Stefan H, Roe, S Mark, Sim, Tiow-Suan, Tan, Doreen, Workman, Paul, Pearl, Laurence H and Piper, Peter W (2009) Structural basis of the radicicol resistance displayed by a fungal hsp90. ACS Chemical Biology, 4 (4). pp. 289-297. ISSN 1554-8929

R

Recuero-Checa, María A, Doré, Andrew S, Arias-Palomo, Ernesto, Rivera-Calzada, Angel, Scheres, Sjors H W, Maman, Joseph D, Pearl, Laurence H and Llorca, Oscar (2009) Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex. DNA Repair, 8 (12). pp. 1380-1389. ISSN 1568-7864

Reynolds, John J, El-Khamisy, Sherif F and Caldecott, Keith W (2009) Short-patch single-strand break repair in ataxia oculomotor apraxia-1. In: Symposium on DNA Damage - From Causes to Cures Univ Cambridge, Robinson Coll, Cambridge, ENGLAND, DEC 15-17, 2008, Cambridge, ENGLAND.

Reynolds, John J, El-Khamisy, Sherif F, Katyal, Sachin, Clements, Peter, McKinnon, Peter J and Caldecott, Keith W (2009) Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Molecular and Cellular Biology, 29 (5). pp. 1354-1362. ISSN 0270-7306

Riballo, Enriqueta, Woodbine, Lisa, Stiff, Thomas, Walker, Sarah A., Goodarzi, Aaron A. and Jeggo, Penny A. (2009) XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Research, 37 (2). pp. 482-492. ISSN 0305-1048

Richardson, Christopher J, Gao, Qiong, Mitsopoulous, Costas, Zvelebil, Marketa, Pearl, Laurence H and Pearl, Frances M G (2009) MoKCa database - mutations of kinases in cancer. Nucleic Acids Research, 37 (S1). D824-D831. ISSN 0305-1048

S

Sabbioneda, Simone, Green, Catherine M., Bienko, Marzena, Kannouche, Patricia, Dikic, Ivan and Lehmann, Alan R. (2009) Ubiquitin-binding motif of human DNA polymerase η is required for correct localization. Proceedings of the National Academy of Sciences, 106 (8). E20-E20. ISSN 1091-6490

Sheikh, Md Arif and Taylor, Garry L (2009) Crystal structure of theVibrio choleraeferric uptake regulator (Fur) reveals insights into metal co-ordination. Molecular Microbiology, 72 (5). pp. 1208-1220. ISSN 0950-382X

Shore, David and Bianchi, Alessandro (2009) Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO Journal, 28 (16). pp. 2309-2322. ISSN 0261-4189

Shore, David and Bianchi, Alessandro (2009) Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO Journal, 28 (16). pp. 2309-2322. ISSN 0261-4189

Skilton, Andrew, Outwin, Emily, Mercer, Brenda, Ho, J C Y and Watts, Felicity (2009) SUMO chain formation is required for response to replication arrest in S. pombe. PLoS ONE, 4 (8). e6750. ISSN 1932-6203

Slupianek, A, Jozwiakowski, Stanislaw, Gurdek, E and Skorski, T (2009) BCR/ABL kinase interacts with and phosphorylates the RAD51 paralog, RAD51B. Leukemia, 23 (12). pp. 2308-10. ISSN 08876924

Sweet, Steve, Bailey, C.M, Cunningham, D.L., Heath, J.K and Cooper, H.J. (2009) Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. Molecular and Cellular Proteomics, 8 (5). pp. 904-912. ISSN 15359476

Sweet, Steve, Jones, AW, Cunningham, DL, Heath, JK, Creese, AJ and Cooper, HJ (2009) Database search strategies for proteomic data sets generated by electron capture dissociation mass spectrometry. Journal of Proteome Research, 8 (12). p. 5475. ISSN 15353893

T

Titman, Christopher M, Downs, Jessica A, Oliver, Stephen G, Carmichael, Paul L, Scott, Andrew D and Griffin, Julian L (2009) A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae. Molecular BioSystems, 5 (12). pp. 1913-1924. ISSN 1742-206X

V

Vaughan, Cara K, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2009) A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. FEBS Journal, 276 (1). pp. 199-209. ISSN 1742-464X

This list was generated on Sun Dec 15 10:59:37 2019 GMT.