A

Abdullah, Mohammed F F, Hoffmann, Eva R, Cotton, V E and Borts, Rhona H (2004) A Role for MutL Homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast. Cytogenetic and Genome Research, 107. pp. 180-190.

Alderton, Gemma K, Joenje, Hans, Varon, Raymonda, Børglum, Anders D, Jeggo, Penny A and O'Driscoll, Mark (2004) Seckel syndrome exhibits cellular features demonstrating defects in the ATR signalling pathway. Human Molecular Genetics, 13 (24). pp. 3127-3138. ISSN 0964-6906

Arlett, Colin F and Lehmann, Alan R (2004) Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer. In: Eeles, R A, Easton, D F, Ponder, B A J and Eng, C (eds.) Genetic predisposition to Cancer (2nd Edition). Arnold, London, pp. 214-231. ISBN 0340762543

B

Bianchi, Alessandro, Negrini, Simona and Shore, David (2004) Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1. Molecular Cell, 16 (1). pp. 139-146. ISSN 1097-2765

C

Caldecott, Keith (2004) DNA single-strand breaks and neurodegeneration. DNA Repair, 3 (8-9). pp. 875-882. ISSN 1568-7864

Clements, Paula M, Breslin, Claire, Deeks, Emma D, Byrd, Philip J, Ju, Limei, Bieganowski, Pawel, Brenner, Charles, Moreira, Maria-Céu, Taylor, A Malcolm R and Caldecott, Keith W (2004) The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. DNA Repair, 3 (11). pp. 1493-1502. ISSN 1568-7864

Collis, Spencer J, DeWeese, Theodore L, Jeggo, Penny A and Parker, Antony R (2004) The life and death of DNA-PK. Oncogene, 24 (6). pp. 949-961. ISSN 1476-5594

D

Della, Marina, Palmbos, Phillip L, Tseng, Hui-Min, Tonkin, Louise M, Daley, James M, Topper, Leana M, Pitcher, Robert S, Tomkinson, Alan E, Wilson, Thomas E and Doherty, Aidan J (2004) Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science, 306 (5696). pp. 683-685. ISSN 0036-8075

Dianova, Irina I, Sleeth, Kate M, Allinson, Sarah L, Parsons, Jason L, Breslin, Claire, Caldecott, Keith W and Dianov, Grigory L (2004) XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. Nucleic Acids Research, 32 (8). pp. 2550-2555. ISSN 0305-1048

Downs, Jessica A, Allard, Stéphane, Jobin-Robitaille, Olivier, Javaheri, Ali, Auger, Andréanne, Bouchard, Nathalie, Kron, Stephen J, Jackson, Stephen P and Côté, Jacques (2004) Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Molecular Cell, 16 (6). pp. 979-990. ISSN 1097-2765

E

Englander, Joseph, Klein, Eugenia, Brumfeld, Vlad, Sharma, Ajay K, Doherty, Aidan J and Minsky, Abraham (2004) DNA toroids: framework for DNA repair in Deinococcus radiodurans and in germinating bacterial spores. Journal of Bacteriology, 186 (18). pp. 5973-5977. ISSN 5973-5977

F

Furuya, Kanji, Poitelea, Marius, Guo, Liandi, Caspari, Thomas and Carr, Antony M (2004) Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes & Development, 18. pp. 1154-1164. ISSN 0890-9369

G

Gennery, A.R, Slatter, M.A., Bhattacharya, A, Barge, D, Haigh, S, O'Driscoll, Mark, Coleman, R, Abinun, M, Flood, T.J, Cant, A.J and Jeggo, Penny (2004) The clinical and biological overlap between Nijmegen Breakage syndrome and Fanconi Anemia. Clinical Immunology, 113 (2). pp. 214-219. ISSN 1521-6616

Giménez-Abián, M I, Rozalén, A E, Carballo, J A, Botella, ML, Pincheira, J, López-Sáez, J F and de la Torre, C (2004) HSP90 and checkpoint-dependent lengthening of the G2 phase observed in plant cells under hypoxia and cold. Protoplasma, 223 (2-4). pp. 191-196. ISSN 0033-183X

Girard, Pierre-Marie, Kysela, Boris, Härer, Christine J, Doherty, Aidan J and Jeggo, Penny A (2004) Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Human Molecular Genetics, 13 (20). pp. 2369-2376. ISSN 0964-6906

Goodarzi, Aaron, Jonnalagadda, Jyoti C, Douglas, Pauline, Young, David, Ruiqiong, Ye, Moorhead, Greg BG, Lees-Miller, Susan P and Khanna, Kum Kum (2004) Autophosphorylation of ataxia-telangiectasia mutated (ATM) is regulated by protein phosphatase 2A in vivo. EMBO Journal, 23. pp. 4451-4461. ISSN 0261-4189

Goodarzi, Aaron and Lees-Miller, S.P (2004) Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells. DNA Repair, 3 (7). pp. 753-767. ISSN 15687864

Goodarzi, Aaron, Ye, R, Kurz, E.U, Saito, S, Higashimoto, Y, Lavin, M.F, Appella, E, Anderson, C.W and Lees-Miller, S.P (2004) The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair, 3 (3). pp. 235-244. ISSN 15687864

H

Hoffmann, E R and Borts, R H (2004) Meiotic recombination intermediates and mismatch repair proteins. Cytogenetic and Genome Research, 107. pp. 232-248. ISSN 1424-859X

J

Jowsey, Paul A, Doherty, Aidan J and Rouse, John (2004) Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. Journal of Biological Chemistry, 279 (53). pp. 55562-55569. ISSN 0021-9258

K

Kannouche, Patricia L, Wing, Jonathan and Lehmann, Alan R (2004) Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA: A Possible Mechanism for the Polymerase Switch in Response to DNA Damage. Molecular Cell, 14 (4). pp. 491-500. ISSN 1097-2765

Kobayashi, K, O'Driscoll, Mark, Macpherson, P, Mullenders, L, Vreeswijk, M and Karran, P (2004) XPC lymphoblastoid cells defective in hMutS¿ DNA mismatch repair complex exhibit normal sensitivity to UVC radiation and normal transcription-coupled excision repair of DNA cyclobutane pyrimidine dimers. DNA Repair, 3 (6). pp. 649-657. ISSN 15687864

L

Lehmann, Alan R. (2004) XPV DNA Polymerase and Ultraviolet Damage Bypass. In: Lennarz, William J. and Lane, M. Daniel (eds.) Encyclopedia of Biological Chemistry. Elsevier, New York, pp. 419-421. ISBN 978-0-12-443710-4

Loizou, Joanna I, El-Khamisy, Sherif F, Zlatanou, Anastasia, Moore, David J, Chan, Douglas W, Qin, Jun, Sarno, Stefania, Meggio, Flavio, Pinna, Lorenzo A and Caldecott, Keith W (2004) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell, 117 (1). pp. 17-28. ISSN 0092-8674

M

Mani, Rajam S, Karimi-Busheri, Feridoun, Fanta, Mesfin, Caldecott, Keith W, Cass, Carol E and Weinfeld, Michael (2004) Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA. Biochemistry, 43 (51). pp. 16505-16514. ISSN 0006-2960

Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23. pp. 511-519. ISSN 0261-4189

N

Netherwood, Trudy, Martín-Orúe, Susana M, O'Donnell, Anthony G, Gockling, Sally, Graham, Julia, Mathers, John C and Gilbert, Harry J (2004) Assesssing the survival of transgenic plant DNA in the human gastrointestinal tract. Nature Biotechnology, 22. pp. 204-209.

O

O'Driscoll, Mark (2004) Roles of DNA-PK, ATM and ATR in damage induced H2AX phosphorylation. Cancer Research, 67 (7). pp. 2390-2396.

O'Driscoll, Mark, Gennery, AR, Seidel, J, Concammon, P and Jeggo, Penny (2004) An Overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair, 3 (8-9). pp. 1227-1235. ISSN 15687864

Oliver, A W, Amé, J C, Roe, S M, Good, V, de Murcia, G and Pearl, L H (2004) Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Research, 32 (2). pp. 456-464. ISSN 0305-1048

R

Riballo, Enriqueta, Kühne, Martin, Rief, Nicole, Doherty, Aidan, Smith, Graeme C M, Recio, Marı́a-José, Reis, Caroline, Dahm, Kirsten, Fricke, Andreas, Krempler, Andrea, Parker, Antony R, Jackson, Stephen P, Gennery, Andrew, Jeggo, Penny A and Löbrich, Markus (2004) A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to ¿-H2AX Foci. Molecular Cell, 16 (5). pp. 715-724. ISSN 1097-2765

Rulten, Stuart, Thorpe, Julian, Mosaheb, Sabrina, Kay, John and Cairns, N (2004) Redistribution and Apparent Shortfalls of the Peptidyl-Prolyl cis-trans Isomerase Protein Pin1 within Subcellular Compartments of Neurons in a Range of Frontotemporal Dementias. Neurobiology of Disease.

S

Sander, Miriam, Desaintes, Christian, Pelroy, Richard, Ferro, Wouter, Van Houten, Bennett, Amundson, Sally, Lehmann, Alan, Mullenders, Leon, Sansone, Susanna-Assunta, Stambrook, Peter, van Zeeland, Bert, Vrieling, Harry and Wennborg, Anders (2004) Meeting Report: EU–US Workshop on Molecular Signatures of DNA damage-induced Stress Responses: Cortona, Italy, 26–30 September 2003. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 550 (1-2). pp. 145-181. ISSN 0027-5107

Shiloh, Yosef and Lehmann, Alan R (2004) Maintaining integrity. Nature Cell Biology, 6 (10). pp. 923-928. ISSN 1465-7392

Stiff, Thomas, O'Driscoll, Mark, Rief, N, Iwabuchi, K, Lobrich, M and Jeggo, Penny (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Research, 64 (7). pp. 2390-2396. ISSN 00085472

Stiff, Thomas, Shtivelman, E, Jeggo, Penny and Kysela, B (2004) AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation. DNA Repair, 3 (3). pp. 245-256. ISSN 15687864

T

Tissier, Agnès, Kannouche, Patricia, Reck, Marie-Pierre, Lehmann, Alan R, Fuchs, Robert P P, Cordonnier, Agnès and Unset (2004) Co-localization in replication foci and interaction of human Y-family members, DNA polymerase polη and REVl protein. DNA Repair, 3 (11). pp. 1503-1514. ISSN 1568-7864

V

Vaisman, Alexandra, Lehmann, Alan R and Woodgate, Roger (2004) DNA Polymerases η and ι. Advances in Protein Chemistry, 69. pp. 205-228. ISSN 0065-3233

Vidal, Antonio E, Kannouche, Patricia, Podust, Vladimir N, Yang, Wei, Lehmann, Alan R and Woodgate, Roger (2004) Proliferating Cell Nuclear Antigen-dependent Coordination of the Biological Functions of Human DNA Polymerase ι. Journal of Biological Chemistry, 279 (46). pp. 48360-48368. ISSN 0021-9258

W

Watts, Felicity (2004) SUMO modification of proteins other than transcription factors. Seminars in Cell & Developmental Biology, 15 (2). pp. 211-220. ISSN 10849521

Watts, Felicity (2004) SUMO proteases in sumoylation. In: Wilson, Van G (ed.) Sumoylation: Molecular Biology and Biochemistry. Taylor & Francis, Inc. ISBN 9780954523282

Wheatley, Sally P, Henzing, Alexander J, Dodson, Helen, Khaled, Walid and Earnshaw, William C (2004) Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. Journal of Biological Chemistry, 279 (7). pp. 5655-5660. ISSN 0021-9258

Y

Yamada, Takatomi, Mizuno, Ken-ichi, Hirota, Kouji, Kon, Nina, Wahls, Wayne P, Hartsuiker, Edgar, Murofushi, Hiromu, Shibata, Takehiko and Ohta, Kunihiro (2004) Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO Journal, 23 (8). pp. 1792-1803. ISSN 0261-4189