Article

Parekh, Nikesh, Ali, Khalid, Stevenson, Jennifer M, Davies, J Graham, Schiff, Rebekah, Van Der Cammen, Tischa, Harchowal, Jatinder, Raftery, James and Rajkumar, Chakravarthi (2018) Incidence and cost of medication harm in older adults following hospital discharge: a multicentre prospective study in the UK. British Journal of Clinical Pharmacology. ISSN 1365-2125

Parekh, Nikesh, Ali, Khalid, Page, Amy, Roper, Tom and Rajkumar, Chakravarthi (2018) Incidence of medication-related harm in older adults following hospital discharge: a systematic review. Journal of the American Geriatrics Society. ISSN 1532-5415 (Accepted)

Ali, Khalid, Davies, Kevin, Rajkumar, Chakravarthi and Parekh, Nikesh (2018) Can supporting health literacy reduce medication-related harm in older adults? Therapeutic Advances in Drug Safety, 9 (3). pp. 167-170. ISSN 2042-0986

Ormerod, Emma, Ali, Khalid, Cameron, James, Malik, Muzaffar, Lee, Richard, Getov, Spas and Rajkumar, Chakravarthi (2017) The association between arterial stiffness, initial stroke severity, and 3 week outcomes in ischaemic stroke patients. Journal of Stroke & Cerebrovascular Diseases, 26 (11). pp. 2541-2546. ISSN 1052-3057

Behar, Laura, Chadwick, David, Dunne, Angela, Jones, Christopher I, Procter, Clare, Rajkumar, Chakravarthi, Sharratt, Paula, Stanley, Philip, Whiley, Angela, Wilks, Mark and Llewelyn, Martin J (2017) Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival. Journal of Infection, 75 (1). pp. 20-25. ISSN 01634453

Parekh, Nikesh, Page, Amy, Ali, Khalid, Davies, Kevin and Rajkumar, Chakravarthi (2017) A practical approach to the pharmacological management of hypertension in older people. Therapeutic Advances in Drug Safety, 8 (4). pp. 117-132. ISSN 2042-0986

Rajkumar, Chakravarthi, Antikainen, Riitta L, Peters, Ruth, Beckett, Nigel S, Fagard, Robert H, Wang, Ji-Guang and Bulpitt, Christopher J (2016) Left Ventricular Hypertrophy is a predictor of cardiovascular events in elderly hypertensives: hypertension in the the very elderly trial (HYVET). Journal of Hypertension, 34 (11). pp. 2280-2286. ISSN 0263-6352

Kalra, Lalit, Hodsoll, John, Irshad, Saddif, Smithard, David, Manawadu, Dulka, Rajkumar, Chakravarthi and the STROKE-INF Investigators, (2016) Association between nasogastric tubes, pneumonia, and clinical outcomes in acute stroke patients. Neurology, 87 (13). pp. 1352-1359. ISSN 0028-3878

Bulpitt, Christopher J, Webb, Richard, Beckett, Nigel, Peters, Ruth, Cheek, Elizabeth, Anderson, Craig, Antikainen, Riitta, Staessen, Jan A and Rajkumar, Chakravarthi (2016) Antihypertensive treatment decreases arterial stiffness at night but not during the day. Results from the Hypertension in the Very Elderly Trial. Blood Pressure, 26 (2). pp. 109-114. ISSN 0803-7051

Stevenson, Jennifer, Parekh, Nikesh, Ali, Khalid, Timeyin, Jean, Bremner, Stephen, Van Der Cammen, Tischa, Allen, Jane, Schiff, Rebekah, Harchowal, Jatinder, Davies, Graham and Rajkumar, Chakravarthi (2016) Protocol for a Prospective (P) study to develop a model to stratify the risk (RI) of medication (M) related harm in hospitalized elderly (E) patients in the UK (the PRIME study). BMC Geriatrics, 16 (22). ISSN 1471-2318

Ali, Khalid and Rajkumar, Chakravarthi (2016) Proposing arterial stiffness as an alternative way of assessing risk in transient ischaemic attack (TIA) patients. British Journal of Diabetes and Vascular Disease, 16 (1). pp. 16-19. ISSN 1474-6514

Kilarski, Laura L, Rutten-Jacobs, Loes C A, Bevan, Steve, Baker, Rob, Hassan, Ahamad, Hughes, Derralynn A, Markus, Hugh S and Rajkumar, Chakravarthi (2015) Prevalence of CADASIL and Fabry disease in a Cohort of MRI defined younger onset lacunar stroke. PLoS One. ISSN 1932-6203

Ghezzi, Pietro and Rajkumar, Chakravarthi (2015) Is frailty in the elderly linked to inflammation? Age and Ageing, 44 (6). pp. 913-914. ISSN 0002-0729

Benetos, Athanase, Rossignol, Patrick, Cherubini, Antonio, Joly, Laure, Grodzicki, Tomasz, Rajkumar, Chakravarthi, Strandberg, Timo E and Petrovic, Mirko (2015) Polypharmacy in the aging patient: management of hypertension in octogenarians. JAMA, 314 (2). p. 170. ISSN 0098-7484

Fantin, F, Bulpitt, C J, Zamboni, M, Cheek, E and Rajkumar, C (2015) Arterial compliance may be reduced by ingestion of red wine. Journal of Human Hypertension. pp. 1-5. ISSN 0950-9240

Rajkumar, Chakravarthi (2014) Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke: secondary analyses from CLOTS 3, a randomised trial. The Lancet Neurology, 13 (12). pp. 1186-1192.

Rajkumar, Chakravarthi and Wright, Juliet (2014) Development and validation of a risk model for predicting adverse drug reactions in older people during hospital stay: Brighton Adverse Drug Reactions Risk (BADRI) model. PLoS One, 9 (10). p. 111254. ISSN 1932-6203

Cheek, E and Rajkumar, C (2014) How to present statistics in medical journals. Age and Ageing, 43 (3). pp. 306-308. ISSN 0002-0729

Bunting, Eva, Rajkumar, Chakravarthi and Fisher, Martin (2014) The human immunodeficiency virus and ageing. Age and Ageing, 43 (3). pp. 308-310. ISSN 0002-0729

Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Bodenham, Emma, McMahon, Lawrence P, Farese, Stefan, Rajkumar, Chakravarthi, Holt, Stephen G and Pasch, Andreas (2014) Serum calcification propensity predicts all-cause mortality in predialysis CKD. Journal of the American Society of Nephrology, 25 (2). pp. 339-348. ISSN 1046-6673

van der Cammen, Tischa J M, Rajkumar, Chakravarthi, Onder, Graziano, Sterke, Carolyn S and Petrovic, Mirko (2014) Drug cessation in complex older adults: time for action. Age and Ageing, 43 (1). pp. 20-25. ISSN 0002-0729

Rajkumar, Chakravarthi and CLOTS Trials Collaboration, et al (2013) Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial. Lancet, 382 (9891). pp. 516-524.

Tangiisuran, B, Auyeung, V, Cheek, L, Rajkumar, C and Davies, J Graham (2013) Inter-rater reliability of the assessment of adverse drug reactions in the hospitalised elderly. Journal of Nutrition, Heath and Ageing, 17 (8). pp. 700-705. ISSN 1279-7707

Bulpitt, Christopher J, Beckett, Nigel, Peters, Ruth, Staessen, Jan A, Wang, Ji-Guang, Comsa, Marius, Fagard, Robert H, Dunitrascu, Dan, Gergova, Vesselka, Antikainen, Riitta L, Cheek, Elizabeth and Rajkumar, Chakravarthi (2013) Response to HYVET ambulatory blood pressure substudy. Hypertension, 61 (5). e43. ISSN 0194-911X

Onder, Graziano, van der Cammen, Tischa J M, Petrovic, Mirko, Somers, Annemie and Rajkumar, Chakravarthi (2013) Strategies to reduce the risk of iatrogenic illness in complex older adults. Age and Ageing, 42 (3). pp. 284-291. ISSN 0002-0729

Antikainen, Ritta L, Beckett, Nigel, Peters, Ruth, Fagard, Robert, Rajkumar, Chakravarthi, Wang, Jiguang, Stoyanovsky, Vassil, Barrowdale, Daniel and Bulpitt, Christopher J (2013) Prevalence and covariates of electrocardiographic left ventricular hypertrophy in the Hypertension in the Very Elderly Trial. Journal of Hypertension, 31 (6). pp. 1224-1232. ISSN 0263-6352

Bulpitt, Christopher J, Beckett, Nigel, Peters, Ruth, Staessen, Jan A, Wang, Ji-Guang, Comsa, Marius, Fagard, Robert H, Dumitrascu, Dan, Gergova, Vesselka, Antikainen, Riitta L, Cheek, Elizabeth and Rajkumar, Chakravarthi (2013) Does white coat hypertension require treatment over age 80?: Results of the hypertension in the very elderly trial ambulatory blood pressure side project. Hypertension, 61 (1). pp. 89-94. ISSN 0194-911X

Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, McMahon, Lawrence P, Rajkumar, Chakravarthi and Holt, Stephen G (2012) FGF23 adds value to risk prediction in patients with chronic kidney disease. Bone, 51 (4). pp. 830-831. ISSN 1873-2763

Tangiisuran, Balamurugan, Davies, J Graham, Wright, Juliet E and Rajkumar, Chakravarthi (2012) Adverse drug reactions in a population of hospitalized very elderly patients. Drugs & Aging, 29 (8). pp. 669-679. ISSN 1170-229X

Fantin, Francesco, Zamboni, Mauro and Rajkumar, Chakravarthi (2012) Abdominal fat is dangerous for arteries even in older people. Age and Ageing, 41 (4). pp. 427-428. ISSN 0002-0729

Islam, J, Cohen, J, Rajkumar, C and Llewelyn, M J (2012) Probiotics for the prevention and treatment of Clostridium difficile in older patients. Age and Ageing, 41 (6). pp. 706-711. ISSN 0002-0729

Smith, Edward R, Tomlinson, Laurie A, Ford, Martin L, McMahon, Lawrence P, Rajkumar, Chakravarthi and Holt, Stephen G (2012) Elastin degradation is associated with progressive aortic stiffening and all-cause mortality in predialysis chronic kidney disease. Hypertension, 59 (5). pp. 973-978. ISSN 1524-4563

Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Rajkumar, Chakravarthi, McMahon, Lawrence P and Holt, Stephen G (2012) Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 27 (5). pp. 1957-1966. ISSN 1460-2385

Sivapathasuntharam, Dhanupriya, Hyde, Jonathan A J, Reay, Victoria and Rajkumar, Chakravarthi (2012) Recurrent strokes caused by a malpositioned pacemaker lead. Age and Ageing, 41 (3). pp. 420-421. ISSN 0002-0729

Ford, Martin L, Smith, Edward R, Tomlinson, Laurie A, Chatterjee, Prabal K, Rajkumar, Chakravarthi and Holt, Stephen G (2012) FGF-23 and osteoprotegerin are independently associated with myocardial damage in chronic kidney disease stages 3 and 4. Another link between chronic kidney disease-mineral bone disorder and the heart. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 27 (2). pp. 727-733. ISSN 1460-2385

Ford, M L, Smith, E R, Tomlinson, L A, Chatterjee, P K, Rajkumar, C and Holt, S G (2012) FGF-23 and osteoprotegerin are independently associated with myocardial damage in chronic kidney disease stages 3 and 4. Another link between chronic kidney disease-mineral bone disorder and the heart. Nephrology Dialysis Transplantation, 27 (2). pp. 727-733. ISSN 0931-0509

Ali, Khalid, Walker, Shan, Crook, David, Wingfield, David, Smith, Helen, Bulpitt, Chris and Rajkumar, Chakravarthi (2011) Experience from a pilot study of a nurse-led hypertension clinic in general practice. Journal of Evaluation In Clinical Practice, 17 (6). pp. 1239-1242. ISSN 1356-1294

Dennis, M, Mordi, N, Graham, C, Sandercock, P, on behalf of the CLOTS trial collaboration, and Rajkumar, Chakravarthi (2011) The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials. Journal of Thrombosis and Haemostasis, 9 (11). pp. 2193-2200. ISSN 1538-7933

Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Weaving, Gary, Holt, Stephen G, Rajkumar, Chakravarthi and Chatterjee, Prabal K (2011) Factors associated with increasing vascular stiffness in PD. Nephrology Dialysis Transplantation, 26 (6). pp. 2060-2061. ISSN 0931-0509

Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Weaving, Gary, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2011) Instability of fibroblast growth factor-23 (FGF-23): implications for clinical studies. Clinica Chimica Acta, 412 (11-12). pp. 1008-1011. ISSN 1873-3492

Bolton, Emily and Rajkumar, Chakravarthi (2011) The ageing cardiovascular system. Reviews in Clinical Gerontology, 21 (2). pp. 99-109. ISSN 0959-2598

Thompson, Philip, Wright, Juliet and Rajkumar, Chakravarthi (2011) Non-pharmacological treatments for orthostatic hypotension. Age and Ageing, 40 (3). pp. 292-293. ISSN 0002-0729

Ali, Khalid, Leong, Kevin Ming Wei, Houlder, Stephanie, Getov, Spas, Lee, Richard and Rajkumar, Chakravarthi (2011) The relationship between dipping profile in blood pressure and neurologic deficit in early acute ischemic stroke. Journal of Stroke & Cerebrovascular Diseases, 20 (1). pp. 10-5. ISSN 1052-3057

Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2010) Poor agreement between commercial ELISAs for plasma fetuin-A: an effect of protein glycosylation? Clinica Chimica Acta, 411 (17-18). pp. 1367-1370. ISSN 0009-8981

Robinson, Thompson G, Potter, John F, Ford, Gary A, Bulpitt, Christopher J, Chernova, Julia, Jagger, Carol, James, Martin A, Knight, Joanne, Markus, Hugh S, Mistri, Amit K, Poulter, Neil R, on behalf of the COSSACS Investigators, and Rajkumar, Chakravarthi (2010) Effects of antihypertensive treatment after acute stroke in the Continue or Stop Post-Stroke Antihypertensives Collaborative Study (COSSACS): a prospective, randomised, open, blinded-endpoint trial. Lancet Neurology, 9 (8). pp. 767-775. ISSN 1474-4422

Onder, Graziano, Petrovic, Mirko, Tangiisuran, Balamurugan, Meinardi, Marieke C, Markito-Notenboom, Winih P, Somers, Annemie, Rajkumar, Chakravarthi, Bernabei, Roberto and van der Cammen, Tischa J M (2010) Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Archives of Internal Medicine, 170 (13). pp. 1142-1148. ISSN 1538-3679

Tangiisuran, Balamurugan and Rajkumar, Chakravarthi (2010) Adverse drug reactions in older people. Reviews in Clinical Gerontology, 20 (3). pp. 246-259. ISSN 0959-2598

Ford, Martin L, Tomlinson, Laurie A, Smith, Edward R, Rajkumar, Chakravarthi and Holt, Stephen G (2010) Fetuin-A is an independent determinant of change of aortic stiffness over 1 year in non-diabetic patients with CKD stages 3 and 4. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association, 25 (6). pp. 1853-1858. ISSN 1460-2385

Smith, Edward R, Ford, Martin L, Tomlinson, Lauria A, Rajkumar, Chakravarthi and Holt, Stephen G (2010) Reply. Nephrology Dialysis Transplantation, 25 (8). pp. 2801-2802. ISSN 0931-0509

Ford, Martin L, Tomlinson, Laurie A, Chapman, Thomas P E, Rajkumar, Chakravarthi and Holt, Stephen G (2010) Aortic stiffness is independently associated with rate of renal function decline in chronic kidney disease stages 3 and 4. Hypertension, 55 (5). pp. 1110-1115. ISSN 1524-4563

Strain, William D, Chaturvedi, Nish, Hughes, Alun, Nihoyannopoulos, Petros, Bulpitt, Christopher J, Rajkumar, Chakravarthi and Shore, Angela C (2010) Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. Journal of Hypertension, 28 (5). pp. 952-958. ISSN 0263-6352

Tangiisura, B, Davies, J G, Cheek, L, Rajkumar, C and Llewelyn, M (2010) Diagnosis of Clostridium difficile infection is associated with a small increased risk of death in elderly inpatients. Journal of Hospital Infection, 74 (4). pp. 401-3. ISSN 0195-6701

Fantin, Francesco, Di Francesco, Vincenzo, Rossi, Andrea, Giuliano, Ketti, Marino, Francesca, Cazzadori, Marco, Gozzoli, Maria P, Vivian, Maria E, Bosello, Ottavio, Rajkumar, Chakravarthi and Zamboni, Mauro (2010) Abdominal obesity and subclinical vascular damage in the elderly. Journal of Hypertension, 28 (2). pp. 333-9. ISSN 0263-6352

Ali, Khalid, Ormerod, Emma and Rajkumar, Chakravarthi (2010) Hyper- or hypotension in an older population: where do clinicians stand? Age and Ageing, 39 (1). pp. 4-5. ISSN 0002-0729

Philippou, Elena, Bovill-Taylor, Candace, Rajkumar, Chakravarthi, Vampa, Maria Luisa, Ntatsaki, Eleana, Brynes, Audrey E, Hickson, Mary and Frost, Gary S (2009) Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study. Metabolism, 58 (12). pp. 1703-1708. ISSN 0026-0495

Tomlinson, Laurie A, Holt, Stephen G, Leslie, Allison R and Rajkumar, Chakravarthi (2009) Prevalence of ambulatory hypotension in elderly patients with CKD stages 3 and 4. Nephrology Dialysis Transplantation, 24 (12). pp. 3751-3755. ISSN 0931-0509

Tangiisuran, Balamurugan, Wright, Juliet, Van der Cammen, Tischa and Rajkumar, Chakravarthi (2009) Adverse drug reactions in elderly: challenges in identification and improving preventative strategies. Age and Ageing, 38 (4). pp. 358-359. ISSN 0002-0729

Dockery, Frances, Bulpitt, Christopher J, Agarwal, Sanjiv, Vernon, Clare and Rajkumar, Chakravarthi (2009) Effect of androgen suppression compared with androgen receptor blockade on arterial stiffness in men with prostate cancer. Journal of Andrology, 30 (4). pp. 410-415. ISSN 0196-3635

Ali, Khalid, Rajkumar, Chakravarthi, Fantin, Francesco, Schiff, Rebekah and Bulpitt, Christopher J (2009) Irbesartan improves arterial compliance more than lisinopril. Vascular Health and Risk Management, 5 (4). pp. 587-592. ISSN 1178-2048

Fantin, Francesco, Bulpitt, C J, Bonapace, S, Cameron, J D and Rajkumar, C (2009) Is vascular stiffness associated with the diameter of the abdominal aorta? Age and Ageing, 38 (4). pp. 466-469. ISSN 0002-0729

Schiff, Rebekah, Shaw, Rory, Raja, Nadia, Rajkumar, Chakravarthi and Bulpitt, Christopher J (2009) Advance end-of-life healthcare planning in an acute NHS hospital setting; development and evaluation of the Expression of Healthcare Preferences (EHP) document. Age and Ageing, 38 (1). pp. 81-85. ISSN 0002-0729

Dhoat, Sasha, Ali, Khalid, Bulpitt, Christopher J and Rajkumar, Chakravarthi (2008) Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease. Age and Ageing, 37 (6). pp. 653-659. ISSN 0002-0729

Getov, S V, Lee, R W, Dockery, F and Rajkumar, C (2008) Androgens, ageing and vascular function. Age and Ageing, 37 (4). pp. 361-3. ISSN 0002-0729

Beckett, Nigel S, Peters, Ruth, Fletcher, Astrid E, Staessen, Jan A, Liu, Lisheng, Dumitrascu, Dan, Stoyanovsky, Vassil, Antikainen, Riitta L, Nikitin, Yuri, Anderson, Craig, Belhani, Alli, Forette, Francoise, Rajkumar, Chakravarthi, Thijs, Lutgarde, Banya, Winston and Bulpitt, Christopher J (2008) Treatment of hypertension in patients 80 years of age or older. New England Journal of Medicine, 358 (18). pp. 1887-1898. ISSN 1533-4406

Dockery, Frances, Bulpitt, Christopher J, Agarwal, Sanjiv, Vernon, Clare, Nihoyannopoulos, Petros, Kemp, Martin, Hooper, James and Rajkumar, Chakravarthi (2008) Anti-androgens increase N-terminal pro-BNP levels in men with prostate cancer. Clinical Endocrinology, 68 (1). pp. 59-65. ISSN 0300-0664

Hickson, Mary, D'Souza, Aloysius L., Muthu, Nirmala, Rogers, Thomas R., Want, Susan, Rajkumar, Chakravarthi and Bulpitt, Christopher J. (2007) Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. British Medical Journal, 335 (7610). pp. 80-83. ISSN 0959-8138

Book Section

Houlder, Stephanie, Fahey, Tom, Ali, Khalid and Rajkumar, Chakravarthi (2009) Managing cardiovascular diseases in older people. In: Gosney, Margot and Harris, Tess (eds.) Managing older people in primary care: a practical guide. Oxford University Press, Oxford: New York, pp. 29-44. ISBN 9780199546589

Conference or Workshop Item

Rajkumar, Chakravarthi (2017) [Abstract] Aortic stiffness and central systolic pressure are associated with orthostatic hypotension in patients with chronic kidney disease. In: ARTERY 2017, 12-14 October 2017, Pisa, Italy.

Rajkumar, Chakravarthi, Davies, Kevin and Kern, Florian (2017) Does arterial ageing differ between Europeans and Japanese and Korean patient samples? Results from current UK studies. In: ARTERY 2017, 12-14 October 2017, Pisa, Italy.

Rajkumar, Chakravarthi, Mengozzi, Manuela and Ghezzi, Pietro (2017) The role of novel biomarkers of inflammation in arterial stiffness, and in predicting further vascular events after TIA and lacunar stroke. In: ARTERY 2017, 12-14 October 2017, Pisa, Italy.

Rajkumar, Chakravarthi, Davies, Kevin and Kern, Florian (2017) Are you really as old as your arteries: predicting biological age using the Cardio-Ankle Vascular Index as a marker of vascular stiffness. In: British Geriatric Society Cardiovascular section, 6th October 2017, London.

Rajkumar, Chakravarthi and Ali, Khalid (2016) Cardio-ankle vascular index and carotid-femoral pulse wave velocity are closely associated with chronological age. In: ARTERY16, 13-15 Oct 2016, Copenhagen, Denmark.

Wright, Juliet and Rajkumar, Chakravarthi (2016) Sarcopenia and vascular risk in a healthy elderly UK population (BRAVES study). In: ARTERY16, 13-15 Oct 2016, Copenhagen, Denmark.

Morrow, G, Caserta, S, Terrazzini, N, Smith, H, Rajkumar, C and Kern, F (2014) The role of CMV-specific immunity in the association between CMV infection and vascular complications in older age. In: British Society of Immunology 2014, 1-4 December 2014, Brighton, UK.