Article

Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte E L, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica J R, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances M G and Oliver, Antony W (2021) Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife, 10. a65339 1-32. ISSN 2050-084X

Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553

Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021

Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A, Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H, Pearl, Laurence H, Oliver, Antony W, El-Khamisy, Sherif, Ward, Simon and Atack, John R (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry, 454. pp. 17-22. ISSN 0003-2697

Ogi, Tomoo, Walker, Sarah, Stiff, Tom, Hobson, Emma, Limsirichaikul, Siripan, Carpenter, Gillian, Prescott, Katrina, Suri, Mohnish, Byrd, Philip J, Matsuse, Michiko, Mitsutake, Norisato, Nakazawa, Yuka, Vasudevan, Pradeep, Barrow, Margaret, Stewart, Grant S, Taylor, A Malcolm R, O'Driscoll, Mark and Jeggo, Penny A (2012) Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. PLoS Genetics, 8 (11). e1002945. ISSN 1553-7390

Bicknell, Louise S, Walker, Sarah, Klingseisen, Anna, Stiff, Tom, Leitch, Andrea, Kerzendorfer, Claudia, Martin, Carol-Anne, Yeyati, Patricia, Al Sanna, Nouriya, Bober, Michael, Johnson, Diana, Wise, Carol, Jackson, Andrew P, O'Driscoll, Mark and Jeggo, Penny A (2011) Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nature Genetics, 43 (4). pp. 350-355. ISSN 1061-4036

Riballo, Enriqueta, Woodbine, Lisa, Stiff, Thomas, Walker, Sarah A., Goodarzi, Aaron A. and Jeggo, Penny A. (2009) XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Research, 37 (2). pp. 482-492. ISSN 0305-1048

Griffith, Elen, Walker, Sarah, Martin, Carol-Anne, Vagnarelli, Paola, Stiff, Tom, Vernay, Bertrand, Al Sanna, Nouriya, Saggar, Anand, Hamel, Ben, Earnshaw, William C, Jeggo, Penny A, Jackson, Andrew P and O'Driscoll, Mark (2007) Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nature Genetics, 40 (2). pp. 232-236. ISSN 1061-4036

Deckbar, Dorothee, Birraux, Julie, Krempler, Andrea, Tchouandong, Leopoldine, Beucher, Andrea, Walker, Sarah, Stiff, Tom, Jeggo, Penny and Löbrich, Markus (2007) Chromosome breakage after G2 checkpoint release. Journal of Cell Biology, 176 (6). pp. 749-755. ISSN 0021-9525

Stiff, Thomas, Walker, Sarah A, Cerosaletti, Karen, Goodarzi, Aaron A, Petermann, Eve, Concannon, Pat, O'Driscoll, Mark and Jeggo, Penny A (2006) ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO Journal, 25 (24). pp. 5775-5782. ISSN 0261-4189

Marchetti, Caterina, Walker, Sarah A, Odreman, Federico, Vindigni, Alessandro, Doherty, Aidan J and Jeggo, Penny (2006) Identification of a novel motif in DNA ligases exemplified by DNA ligase IV. DNA Repair, 5 (7). pp. 788-798. ISSN 1568-7864

Weir, Lucinda R, Schenck, Emanuel, Meakin, Jackie, McClure, Fiona, Driver, Roy, Walker, Sarah and Lynch, Anthony M (2005) Biophotonic imaging in HO-1.luc transgenic mice: real-time demonstration of gender-specific chloroform induced renal toxicity. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 574 (1-2). pp. 67-75. ISSN 0027-5107

Lynch, Anthony, Harvey, James, Aylott, Michael, Nicholas, Emma, Burman, Mark, Siddiqui, Ayesha, Walker, Sarah and Rees, Robert (2003) Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity. Mutagenesis, 18 (4). pp. 345-53. ISSN 0267-8357

Thesis

Walker, Sarah A (2012) Investigating the role of the ATR-dependent DNA damage response in the aetiology of microcephalic primordial dwarfism disorders. Doctoral thesis (PhD), University of Sussex.