Items for Caldecott, Keith

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Article

Hoch, Nicolas C, Hanzlikova, Hana, Rulten, Stuart L, Tétreault, Martine, Komulainen, Emilia, Ju, Limei, Hornyak, Peter, Zeng, Zhihong, Gittens, William, Rey, Stephanie A, Staras, Kevin, Mancini, Grazia M S, McKinnon, Peter J, Wang, Zhao-Qi, Wagner, Justin, Yoon, Grace and Caldecott, Keith W (2016) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature, 541 (7635). pp. 87-91. ISSN 0028-0836

Grundy, Gabrielle J, Polo, Luis M, Zeng, Zhihong, Rulten, Stuart, Hoch, Nicolas, Pathompong, Paomephan, Xu, Yingqi, Sweet, Steve M, Thorne, Alan W, Oliver, Antony W, Matthews, Steve J, Pearl, Laurence H and Caldecott, Keith W (2016) PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature Communications, 7 (12404). ISSN 2041-1723

Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021

Grundy, Gabrielle J, Rulten, Stuart L, Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W, Pearl, Laurence H and Caldecott, Keith W (2016) The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Nature Communications, 7. a11242. ISSN 2041-1723

Cherry, Amy L, Nott, Timothy J, Kelly, Geoffrey, Rulten, Stuart L, Caldecott, Keith W and Smerdon, Stephen J (2015) Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains. DNA repair, 35. pp. 116-125. ISSN 1568-7856

Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L, Hanzlikova, Hana, Oliver, Antony W and Caldecott, Keith W (2015) The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function. Nucleic Acids Research, 43 (14). pp. 6934-6944. ISSN 0305-1048

Dai, Xiaoxia, Rulten, Stuart L, You, Changjun, Caldecott, Keith W and Wang, Yinsheng (2015) Identification and functional characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in human Poly(ADP-ribose) Polymerase 3. Journal of proteome research, 14 (6). pp. 2575-2582. ISSN 1535-3907

Grundy, Gabrielle J, Moulding, Hayley A, Caldecott, Keith W and Rulten, Stuart L (2014) One ring to bring them all--the role of Ku in mammalian non-homologous end joining. DNA repair, 17. pp. 30-38. ISSN 1568-7856

Gomez Herreros, Fernando, Schuurs-Hoeijmakers, Janneke H M, McCormack, Mark, Greally, Marie T, Rulten, Stuart, Romero-Granados, Rocio, Counihan, Timothy J, Chaila, Elijah, Conroy, Judith, Ennis, Sean, Delanty, Norman, Cortes-Ledesma, Felipe, de Brouwer, Arjan P M, Cavalleri, Gianpiero L, El-Khamisy, Sherif F, de Vries, Bert B A and Caldecott, Keith (2014) TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics, 46 (5). pp. 516-524. ISSN 1061-4036

Rulten, Stuart L, Rotheray, Amy, Green, Ryan L, Grundy, Gabrielle J, Moore, Duncan A Q, Gómez-Herreros, Fernando, Hafezparast, Majid and Caldecott, Keith W (2014) PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. Nucleic Acids Research, 42 (1). pp. 307-314. ISSN 1362-4962

Rulten, Stuart L and Caldecott, Keith W (2013) DNA strand break repair and neurodegeneration. DNA repair, 12 (8). pp. 558-567. ISSN 1568-7856

Grundy, Gabrielle L, Rulten, Stuart L, Zeng, Zhihong, Arribas-Bosacoma, Raquel, Iles, Natasha, Manley, Katie, Oliver, Antony and Caldecott, Keith W (2013) APLF promotes the assembly and activity of non-homologous end joining protein complexes. The EMBO journal, 32 (1). pp. 112-125. ISSN 1460-2075

Reynolds, John J, Walker, Alexandra K, Gilmore, Edward C, Walsh, Christopher A and Caldecott, Keith W (2012) Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair. Nucleic Acids Research. ISSN 1362-4962

Zeng, Z, Sharma, A, Ju, L, Murai, J, Umans, L, Vermeire, L, Pommier, Y, Takeda, S, Huylebroeck, D, Caldecott, K and El-Khamisy, S (2012) TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Research, 40 (17). pp. 8371-8380. ISSN 1362-4962

Rulten, Stuart L, Fisher, Anna E O, Robert, Isabelle, Zuma, Maria C, Rouleau, Michele, Ju, Limei, Poirer, Guy, Reina-San-Martin, Bernardo and Caldecott, Keith W (2011) PARP-3 and APLF function together to accelerate nonhomologous end-joining. Molecular Cell, 41 (1). pp. 33-45. ISSN 1097-2765

Zeng, Zhihong, Cortes-Ledesma, Felipe, El-Khamisy, Sherif and Caldecott, Keith W (2010) TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. Journal of Biological Chemistry, 286 (1). pp. 403-409. ISSN 0021-9258

Shen, Jun, Gilmore, Edward C, Marshall, Christine A, Haddadin, Mary, Reynolds, John J, Eyaid, Wafaa, Bodell, Adria, Barry, Brenda, Gleason, Danielle, Allen, Kathryn, Ganesh, Vijay S, Chang, Bernard S, Grix, Arthur, Hill, R Sean, Topcu, Meral, Caldecott, Keith W, Barkovich, A James and Walsh, Christopher A (2010) Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nature Genetics, 42 (3). 245-U38. ISSN 1061-4036

Rulten, Stuart L., Fisher, Anna E O, Robert, Isabelle, Zuma, Maria C., Rouleau, Michele, Ju, Limei, Poirier, Guy, Reina-San-Martin, Bernardo and Caldecott, Keith W. (2010) PARP-3 and APLF Function Together to Accelerate Non-Homologous End Joining. Molecular Cell, 41 (1). pp. 33-45. ISSN 1097-2765

Cortes Ledesma, Felipe, El-Khamisy, Sherif F, Zuma, Maria C, Osborn, Kay and Caldecott, Keith W (2009) A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature, 461 (7264). pp. 674-678. ISSN 0028-0836

Breslin, Claire and Caldecott, Keith W (2009) DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress. Molecular and Cellular Biology, 29 (17). pp. 4653-4662. ISSN 0270-7306

Lee, Youngsoo, Katyal, Sachin, Li, Yang, El-Khamisy, Sherif F, Russell, Helen R, Caldecott, Keith W and McKinnon, Peter J (2009) The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nature Neuroscience, 12 (8). 973-U35. ISSN 1097-6256

Dungey, Fiona A, Caldecott, Keith W and Chalmers, Anthony J (2009) Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics, 8 (8). pp. 2243-2254. ISSN 1535-7163

Dungey, Fiona A, Caldecott, Keith W and Chalmers, Anthony J (2009) Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics, 8 (8). pp. 2243-2254. ISSN 1535-7163

El-Khamisy, Sherif F, Katyal, Sachin, Patel, Poorvi, Ju, Limei, McKinnon, Peter J and Caldecott, Keith W (2009) Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair, 8 (6). pp. 760-766. ISSN 1568-7864

Reynolds, John J, El-Khamisy, Sherif F, Katyal, Sachin, Clements, Peter, McKinnon, Peter J and Caldecott, Keith W (2009) Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Molecular and Cellular Biology, 29 (5). pp. 1354-1362. ISSN 0270-7306

Caldecott, Keith (2008) Single-strand break repair and genetic disease. Nature Reviews Genetics, 9 (8). pp. 619-631. ISSN 0028-0836

Rulten, Stuart L, Cortes-Ledesma, Felipe, Guo, Liandi, Iles, Natasha J and Caldecott, Keith W (2008) APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Molecular and Cellular Biology, 28 (14). pp. 4620-4628. ISSN 0270-7306

Caldecott, Keith W (2008) Preface. DNA Repair, 7 (7). p. 1009. ISSN 1568-7864

Rulten, Stuart, Cortes-Ledesma, Felipe, Guo, Liandi, Iles, Natasha and Caldecott, Keith (2008) APLF (C2orf13) Is a Novel Component of Poly(ADP-Ribose)Signaling in Mammalian Cells. Molecular and Cellular Biology, 28 (14). pp. 4620-4628. ISSN 0270-7306

Caldecott, Keith (2008) Special Issue - DNA damage responses and neurological disease - Preface. DNA Repair, 7 (7). p. 1009. ISSN 15687864

Petermann, Eva, Helleday, Thomas and Caldecott, Keith W (2008) Claspin promotes normal replication fork rates in human cells. Molecular Biology of the Cell, 19 (6). pp. 2373-2378. ISSN 1059-1524

Katyal, Sachin, El-Khamisy, Sherif F, Russell, Helen R, Liu, Yang, Ju, Limei, Caldecott, Keith W and McKinnon, Peter J (2007) TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO Journal, 26. pp. 4720-4731. ISSN 0261-4189

El-Khamisy, Sherif F, Hartsuiker, Edgar and Caldecott, Keith W (2007) TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. DNA Repair, 6 (10). pp. 1485-1495. ISSN 1568-7864

Mani, Rajam S, Fanta, Mesfin, Karimi-Busheri, Feridoun, Silver, Elizabeth, Virgen, César A, Caldecott, Keith W, Cass, Carol E and Weinfeld, Michael (2007) XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates. Journal of Biological Chemistry, 282 (38). pp. 28004-28013. ISSN 0021-9258

Moser, Jill, Kool, Hanneke, Giakzidis, Ioannis, Caldecott, Keith, Mullenders, Leon H F and Fousteri, Maria I (2007) Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. Molecular and Cellular Biology, 27 (2). pp. 311-323. ISSN 0270-7306

Maya-Mendoza, Apolinar, Petermann, Eva, Gillespie, David A F, Caldecott, Keith W and Jackson, Dean A (2007) Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO Journal, 26 (11). pp. 2719-2731. ISSN 0261-4189

Iles, Natasha, Rulten, Stuart, El-Khamisy, Sherif F and Caldecott, Keith W (2007) APLF (C2orf13) Is a Novel Human Protein Involved in the Cellular Response to Chromosomal DNA Strand Breaks. Molecular and Cellular Biology, 27 (10). pp. 3793-3803. ISSN 0270-7306

Iles, Natasha, Rulten, Stuart L., El-Khamisy, Sherif F. and Caldecott, Keith W. (2007) APLF (C2orf13) is a Novel Human Protein Involved in the Cellular Response to Chromosomal DNA Strand Breaks. Molecular and Cellular Biology, 27 (10). pp. 3793-3803. ISSN 0270-7306

Iles, Natasha, Rulten, Stuart, El-Khamisy, Sherif F. and Caldecott, Keith W (2007) APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Molecular and Cellular Biology, 27 (10). pp. 3793-3803. ISSN 0270-7306

El-Khamisy, S F and Caldecott, K W (2007) DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. Neuroscience, 145 (4). pp. 1260-1266. ISSN 0306-4522

Caldecott, K W (2007) DNA Single-Strand Break Repair and Spinocerebellar Ataxia with Axonal Neuropathy-1. Neuroscience, 145 (4). pp. 1260-1266. ISSN 0306-4522

Caldecott, Keith W. (2007) Mammalian single-strand break repair: Mechanisms and links with chromatin. DNA Repair, 6 (4: Rep). pp. 443-453. ISSN 1568-7864

Caldecott, Keith (2007) Mammalian Single-Strand Break Repair; Mechanisms and Links with Chromatin. DNA Repair, 6 (4). pp. 443-453. ISSN 1568-7864

Fisher, Anna E O, Hochegger, Helfrid, Takeda, Shunichi and Caldecott, Keith W (2007) Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase. Molecular and Cellular Biology, 27 (15). pp. 5597-5605. ISSN 0270-7306

Petermann, Eva and Caldecott, Keith W (2006) Evidence that the ATR/Chk 1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle, 5 (19). pp. 2203-2209. ISSN 1551-4005

El-Khamisy, Sherif F and Caldecott, Keith W (2006) TDP1-dependent DNA single-strand break repair and neurodegeneration. Mutagenesis, 21 (4). pp. 219-224. ISSN 0267-8357

Petermann, Eva, Maya-Mendoza, Apolinar, Zachos, George, Gillespie, David A F, Jackson, Dean A and Caldecott, Keith W (2006) Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase. Molecular and Cellular Biology, 26 (8). pp. 3319-3326. ISSN 0270-7306

Ahel, Ivan, Rass, Ulrich, El-Khamisy, Sherif F, Katyal, Sachin, Clements, Paula M, McKinnon, Peter J, Caldecott, Keith W and West, Stephen C (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature, 443. pp. 713-716. ISSN 0028-0836

Breslin, Claire, Clements, Paula M, El-Khamisy, Sherif F, Petermann, Eva, Iles, Natasha and Caldecott, Keith W (2006) Measurement of chromosomal DNA single-strand breaks and replication fork progression rates. Methods in Enzymology, 409. pp. 410-425. ISSN 0076-6879

El-Khamisy, Sherif F, Saifi, Gulam M, Weinfeld, Michael, Johansson, Fredrik, Helleday, Thomas, Lupski, James R and Caldecott, Keith W (2005) Defective DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. Nature, 434. pp. 108-113. ISSN 0306-4522

El-Khamisy, Sherif F, Saifi, Gulam M, Weinfeld, Michael, Johansson, Fredrik, Helleday, Thomas, Lupski, James R and Caldecott, Keith W (2005) Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature, 434. pp. 108-113. ISSN 0028-0836

Caldecott, K. W. and Chalmers, A. (2005) An Achilles' heel for breast cancer? Nature Structural and Molecular Biology, 12 (5). pp. 387-8. ISSN 1545-9993

El-Khamisy, S. F., Saifi, G. M., Weinfeld, M., Johansson, F., Helleday, T., Lupski, J. R. and Caldecott, K. W. (2005) Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature, 434 (7029). pp. 108-13. ISSN 1476-4687

Mani, Rajam S, Karimi-Busheri, Feridoun, Fanta, Mesfin, Caldecott, Keith W, Cass, Carol E and Weinfeld, Michael (2004) Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA. Biochemistry, 43 (51). pp. 16505-16514. ISSN 0006-2960

Caldecott, Keith (2004) DNA single-strand breaks and neurodegeneration. DNA Repair, 3 (8-9). pp. 875-882. ISSN 1568-7864

Dianova, Irina I, Sleeth, Kate M, Allinson, Sarah L, Parsons, Jason L, Breslin, Claire, Caldecott, Keith W and Dianov, Grigory L (2004) XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. Nucleic Acids Research, 32 (8). pp. 2550-2555. ISSN 0305-1048

Loizou, Joanna I, El-Khamisy, Sherif F, Zlatanou, Anastasia, Moore, David J, Chan, Douglas W, Qin, Jun, Sarno, Stefania, Meggio, Flavio, Pinna, Lorenzo A and Caldecott, Keith W (2004) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell, 117 (1). pp. 17-28. ISSN 0092-8674

Clements, Paula M, Breslin, Claire, Deeks, Emma D, Byrd, Philip J, Ju, Limei, Bieganowski, Pawel, Brenner, Charles, Moreira, Maria-Céu, Taylor, A Malcolm R and Caldecott, Keith W (2004) The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. DNA Repair, 3 (11). pp. 1493-1502. ISSN 1568-7864

Caldecott, Keith (2003) Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions. DNA Repair, 2 (10). pp. 1087-1100. ISSN 1568-7864

Caldecott, Keith (2003) Cell signaling: The BRCT domain: signaling with friends? Science, 302 (5645). pp. 579-580. ISSN 0036-8075

Nakamura, Jun, Asakura, Shoji, Hester, Susan D, de Murcia, Gilbert, Caldecott, Keith W and Swenberg, James A (2003) Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic Acids Research, 31 (17). e104-e104. ISSN 0305-1048

Caldecott, Keith (2003) XRCC1 and DNA strand break repair. DNA Repair, 2 (9). pp. 955-969. ISSN 1568-7864

Henry-Mowatt, Judith, Jackson, Dean, Masson, Jean-Yves, Johnson, Penny A, Clements, Paula M, Benson, Fiona E, Thompson, Larry H, Takeda, Shunichi, West, Stephen C and Caldecott, Keith W (2003) XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Molecular Cell, 11 (4). pp. 1109-1117. ISSN 1097-2765

Caldecott, Keith (2003) Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions, 31 (1). pp. 247-251. ISSN 0300-5127

Caldecott, Keith (2003) A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Research, 31 (19). pp. 5526-5533. ISSN 0305-1048

Caldecott, K. W. (2003) DNA single-strand break repair and spinocerebellar ataxia. Cell, 112 (1). 7-10.. ISSN 0092-8674

Caldecott, Keith (2003) DNA single-strand break repair and spinocerebellar ataxia. Cell, 112 (1). pp. 7-10. ISSN 0092-8674

Caldecott, K. W. (2003) Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions, 31 (Pt 1). pp. 247-51. ISSN 0300-5127

Okano, Satoshi, Lan, Li, Caldecott, Keith W, Mori, Toshio and Yasui, Akira (2003) Spatial and temporal cellular responses to single-strand breaks in human cells. Molecular and Cellular Biology, 23 (11). pp. 3974-3981. ISSN 1098-5549

Caldecott, Keith (2002) Polynucleotide kinase. A versatile molecule makes a clean break. Structure, 10 (9). pp. 1151-1152. ISSN 0969-2126

Taylor, Richard M, Thistlethwaite, Angela and Caldecott, Keith W (2002) Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair. Molecular and Cellular Biology, 22 (8). 2556-2563.. ISSN 0270-7306

Iftner, Thomas, Elbel, Michaela, Schopp, Betti, Hiller, Thomas, Loizou, Joanna I, Caldecott, Keith W and Stubenrauch, Frank (2002) Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1. EMBO Journal, 21 (17). pp. 4741-4748. ISSN 0261-4189

Caldecott, K.W. (2002) Polynucleotide kinase. A versatile molecule makes a clean break. Structure, 10 (9). pp. 1151-1152. ISSN 0969-2126

Caldecott, Keith (2001) Mammalian DNA single-strand break repair: an X-ra(y)ted affair. BioEssays, 23 (5). pp. 447-455. ISSN 0265-9247

Whitehouse, Claire J, Taylor, Richard M, Thistlethwaite, Angela, Zhang, Hong, Karimi-Busheri, Feridoun, Lasko, Dana D, Weinfeld, Michael and Caldecott, Keith W (2001) XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell, 104 (1). pp. 107-117. ISSN 0092-8674

Book Section

Rulten, Stuart L, Dantzer, Francoise and Caldecott, Keith W (2015) The role of PARPs in DNA strand break repair. In: Curtin, Nicola J and Sharma, Ricky A (eds.) PARP Inhibitors for Cancer Therapy. Cancer Drug Discovery and Development, 83 . Humana Press, New York, pp. 47-78. ISBN 9783319141503

Conference or Workshop Item

Reynolds, John J, El-Khamisy, Sherif F and Caldecott, Keith W (2009) Short-patch single-strand break repair in ataxia oculomotor apraxia-1. In: Symposium on DNA Damage - From Causes to Cures Univ Cambridge, Robinson Coll, Cambridge, ENGLAND, DEC 15-17, 2008, Cambridge, ENGLAND.

This list was generated on Mon Jul 24 21:55:33 2017 BST.