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Vaitsiankova, Alina, Burdova, Kamila, Sobol, Margarita, Gautam, Amit, Benada, Oldrich, Hanzlikova, Hana and Caldecott, Keith W (2022) PARP inhibition impedes the maturation of nascent DNA strands during DNA replication. Nature Structural and Molecular Biology, 29. pp. 329-338. ISSN 1545-9993
Adamowicz, Marek, Hailstone, Richard, Demin, Annie A, Komulainen, Emilia, Hanzlikova, Hana, Brazina, Jan, Gautam, Amit, Wells, Sophie E and Caldecott, Keith W (2021) XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nature Cell Biology. ISSN 1465-7392
Russo, Lilian Cristina, Tomasin, Rebeka, Matos, Isaac Araújo, Manucci, Antonio Carlos, Sowa, Sven T, Dale, Katie, Caldecott, Keith W, Lehtiö, Lari, Schechtman, Deborah, Meotti, Flavia C, Bruni-Cardoso, Alexandre and Hoch, Nicolas Carlos (2021) The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling. Journal of Biological Chemistry, 297 (3). a101041 1-14. ISSN 0021-9258
Demin, Annie A, Hirota, Kouji, Tsuda, Masataka, Adamowicz, Marek, Hailstone, Richard, Brazina, Jan, Gittens, William, Kalasova, Ilona, Shao, Zhengping, Zha, Shan, Sasanuma, Hiroyuki, Hanzlikova, Hana, Takeda, Shunichi and Caldecott, Keith W (2021) XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. Molecular Cell, 81 (14). 3018-3030.e5. ISSN 1097-2765
Wu, Wei, Hill, Sarah E, Nathan, William J, Paiano, Jacob, Callen, Elsa, Wang, Dongpeng, Shinoda, Kenta, van Wietmarschen, Niek, Colón-Mercado, Jennifer M, Zong, Dali, De Pace, Raffaella, Shih, Han-Yu, Coon, Steve, Hanzlikova, Hana, Caldecott, Keith W and others, (2021) Neuronal enhancers are hotspots for DNA single-strand break repair. Nature, 593. pp. 440-444. ISSN 0028-0836
Komulainen, Emilia, Badman, Jack, Rey, Stephanie, Rulten, Stuart, Ju, Limei, Fennell, Kate, Kalasova, Ilona, Ilievova, Kristyna, McKinnon, Peter J, Hanzlikova, Hana, Staras, Kevin and Caldecott, Keith W (2021) Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures. EMBO Reports, 22 (5). a51851 1-12. ISSN 1469-221X
Hanzlikova, Hana, Prokhorova, Evgeniia, Krejcikova, Katerina, Cihlarova, Zuzana, Kalasova, Ilona, Kubovciak, Jan, Sachova, Jana, Hailstone, Richard, Brazina, Jan, Ghosh, Shereen, Cirak, Sebahattin, Gleeson, Joseph G, Ahel, Ivan and Caldecott, Keith W (2020) Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. Nature Communications, 11 (1). a3391 1-13. ISSN 2041-1723
Kalasova, Ilona, Hailstone, Richard, Bublitz, Janin, Bogantes, Jovel, Hofmann, Winfried, Leal, Alejandro, Hanzlikova, Hana and Caldecott, Keith W (2020) Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair. Nucleic Acids Research, 48 (12). pp. 6672-6684. ISSN 0305-1048
Canela, Andres, Marman, Yaakov, Huang, Shar-yin N, Wutz, Gordana, Tang, Wen, Zagnol-iVieira, Guido, Callen, Elsa, Wong, Nancy, Day, Amanda, Peters, Jan-Michael, Pommier, Yves, Caldecott, Keith W and Nussenzweig, André (2019) Topoisomerase II-Induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity. Molecular Cell. ISSN 1097-2765
Komulainen, Emilia, Pennicott, Lewis, Le Grand, Darren and Caldecott, Keith (2019) Deazaflavin inhibitors of TDP2 with cellular activity can affect etoposide influx and/or efflux. ACS Chemical Biology, 14 (6). pp. 1110-1114. ISSN 1554-8929
Kalasova, Ilona, Hanzlikova, Hana, Gupta, Neerja, Li, Yun, Altmüller, Janine, Reynolds, John J, Stewart, Grant S, Wollnick, Bernd, Yigit, Gökhan and Caldecott, Keith W (2019) Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ. Neurology Genetics, 5 (2). pp. 1-7. ISSN 2376-7839
Martinez-Macias, Maria Isabel, Moore, Duncan A Q, Green, Ryan L, Gomez-Herreros, Fernando, Naumann, Marcel, Hermann, Andreas, Van Damme, Philip, Hafezparast, Majid and Caldecott, Keith W (2019) FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress. Life Science Alliance, 2 (2). e201800222 1-14. ISSN 2575-1077
Polo, Luis M, Xu, Yingqi, Hornyak, Peter, Garces, Fernando, Zeng, Zhihong, Hailstone, Richard, Matthews, Steve J, Caldecott, Keith W, Oliver, Antony W and Pearl, Laurence H (2019) Efficient single-strand break repair requires binding to both poly(ADP-ribose) and DNA by the central BRCT domain of XRCC1. Cell Reports, 26 (3). 573-581.e5. ISSN 2211-1247
Zagnol-iVieira, Guido, Bruni, Francesco, Thompson, Kyle, He, Langping, Walker, Sarah, de Brouwer, Arjan P M, Taylor, Robert, Niyazov, Dimitriy and Caldecott, Keith W (2018) Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23). Neurology Genetics, 4 (4). ISSN 2376-7839
Hanzlikova, Hana, Kalasova, Ilona, Demin, Annie A, Pennicott, Lewis E, Cihlarova, Zuzana and Caldecott, Keith W (2018) The importance of Poly(ADP-Ribose) Polymerase as a sensor of unligated Okazaki fragments during DNA replication. Molecular Cell, 71 (2). pp. 319-331. ISSN 1097-2765
Gómez-Herreros, Fernando, Zagnoli-Vieira, Guido, Ntai, Ioanna, Martínez-Macías, María Isabel, Anderson, Rhona M, Herrero-Ruíz, Andrés and Caldecott, Keith W (2017) TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. Nature Communications, 8 (1). a233 1-9. ISSN 2041-1723
Zeng, Zhihong, Rulten, Stuart L, Breslin, Claire, Zlatanou, Anastasia, Coulthard, Victoria and Caldecott, Keith (2017) Acylpeptide hydrolase is a component of the cellular response to DNA damage. DNA Repair, 58. pp. 52-61. ISSN 1568-7864
Breslin, Claire, Mani, Rajam S, Fanta, Mesfin, Hoch, Nicolas, Weinfield, Michael and Caldecott, Keith W (2017) The RIR motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair. Journal of Biological Chemistry, 292. pp. 16024-16031. ISSN 1083-351X
Hanzlikova, Hana, Gittens, William, Krejcikova, Katerina, Zeng, Zhihong and Caldecott, Keith W (2017) Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin. Nucleic Acids Research, 45 (5). pp. 2546-2557. ISSN 1362-4962
Hoch, Nicolas C, Hanzlikova, Hana, Rulten, Stuart L, Tétreault, Martine, Komulainen, Emilia, Ju, Limei, Hornyak, Peter, Zeng, Zhihong, Gittens, William, Rey, Stephanie A, Staras, Kevin, Mancini, Grazia M S, McKinnon, Peter J, Wang, Zhao-Qi, Wagner, Justin D, Care4Rare Canada Consortium, , Yoon, Grace and Caldecott, Keith W (2017) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature, 541. pp. 87-91. ISSN 0028-0836
Grundy, Gabrielle J, Polo, Luis M, Zeng, Zhihong, Rulten, Stuart L, Hoch, Nicolas C, Pathompong, Paomephan, Xu, Yingqi, Sweet, Steve M, Thorne, Alan W, Oliver, Antony W, Matthews, Steve J, Pearl, Laurence H and Caldecott, Keith W (2016) PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature Communications, 7 (1). a12404 1-12. ISSN 2041-1723
Rulten, Stuart and Caldecott, Keith (2016) The PARP inhibitor AZD2461 provides insights into the role of PARP3 inhibition for both synthetic lethality and tolerability with chemotherapy in preclinical models. Cancer Research, 76 (20). ISSN 0008-5472
Grundy, Gabrielle J, Rulten, Stuart L, Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W, Pearl, Laurence H and Caldecott, Keith W (2016) The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Nature Communications, 7 (1). a11242. ISSN 2041-1723
Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021
Cherry, Amy L, Nott, Timothy J, Kelly, Geoffrey, Rulten, Stuart L, Caldecott, Keith W and Smerdon, Stephen J (2015) Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains. DNA repair, 35. pp. 116-125. ISSN 1568-7856
Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L, Hanzlikova, Hana, Oliver, Antony W and Caldecott, Keith W (2015) The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function. Nucleic Acids Research, 43 (14). pp. 6934-6944. ISSN 0305-1048
Dai, Xiaoxia, Rulten, Stuart L, You, Changjun, Caldecott, Keith W and Wang, Yinsheng (2015) Identification and functional characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in human Poly(ADP-ribose) Polymerase 3. Journal of proteome research, 14 (6). pp. 2575-2582. ISSN 1535-3907
Gomez Herreros, Fernando, Schuurs-Hoeijmakers, Janneke H M, McCormack, Mark, Greally, Marie T, Rulten, Stuart, Romero-Granados, Rocio, Counihan, Timothy J, Chaila, Elijah, Conroy, Judith, Ennis, Sean, Delanty, Norman, Cortes-Ledesma, Felipe, de Brouwer, Arjan P M, Cavalleri, Gianpiero L, El-Khamisy, Sherif F, de Vries, Bert B A and Caldecott, Keith W (2014) TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics, 46 (5). pp. 516-521. ISSN 1061-4036
Grundy, Gabrielle J, Moulding, Hayley A, Caldecott, Keith W and Rulten, Stuart L (2014) One ring to bring them all--the role of Ku in mammalian non-homologous end joining. DNA repair, 17. pp. 30-38. ISSN 1568-7856
Rulten, Stuart L, Rotheray, Amy, Green, Ryan L, Grundy, Gabrielle J, Moore, Duncan A Q, Gómez-Herreros, Fernando, Hafezparast, Majid and Caldecott, Keith W (2014) PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. Nucleic Acids Research, 42 (1). pp. 307-314. ISSN 1362-4962
Rulten, Stuart L and Caldecott, Keith W (2013) DNA strand break repair and neurodegeneration. DNA repair, 12 (8). pp. 558-567. ISSN 1568-7856
Grundy, Gabrielle L, Rulten, Stuart L, Zeng, Zhihong, Arribas-Bosacoma, Raquel, Iles, Natasha, Manley, Katie, Oliver, Antony and Caldecott, Keith W (2013) APLF promotes the assembly and activity of non-homologous end joining protein complexes. The EMBO journal, 32 (1). pp. 112-125. ISSN 1460-2075
Reynolds, John J, Walker, Alexandra K, Gilmore, Edward C, Walsh, Christopher A and Caldecott, Keith W (2012) Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair. Nucleic Acids Research, 40 (14). pp. 6608-6619. ISSN 1362-4962
Zeng, Z, Sharma, A, Ju, L, Murai, J, Umans, L, Vermeire, L, Pommier, Y, Takeda, S, Huylebroeck, D, Caldecott, K and El-Khamisy, S (2012) TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Research, 40 (17). pp. 8371-8380. ISSN 1362-4962
Rulten, Stuart L, Fisher, Anna E O, Robert, Isabelle, Zuma, Maria C, Rouleau, Michele, Ju, Limei, Poirier, Guy, Reina-San-Martin, Bernardo and Caldecott, Keith W (2011) PARP-3 and APLF function together to accelerate nonhomologous end joining. Molecular Cell, 41 (1). pp. 33-45. ISSN 1097-2765
Zeng, Zhihong, Cortés-Ledesma, Felipe, El-Khamisy, Sherif F and Caldecott, Keith W (2010) TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. Journal of Biological Chemistry, 286 (1). pp. 403-409. ISSN 0021-9258
Shen, Jun, Gilmore, Edward C, Marshall, Christine A, Haddadin, Mary, Reynolds, John J, Eyaid, Wafaa, Bodell, Adria, Barry, Brenda, Gleason, Danielle, Allen, Kathryn, Ganesh, Vijay S, Chang, Bernard S, Grix, Arthur, Hill, R Sean, Topcu, Meral, Caldecott, Keith W, Barkovich, A James and Walsh, Christopher A (2010) Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nature Genetics, 42 (3). 245-U38. ISSN 1061-4036
Cortes Ledesma, Felipe, El-Khamisy, Sherif F, Zuma, Maria C, Osborn, Kay and Caldecott, Keith W (2009) A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature, 461 (7264). pp. 674-678. ISSN 0028-0836
Breslin, Claire and Caldecott, Keith W (2009) DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress. Molecular and Cellular Biology, 29 (17). pp. 4653-4662. ISSN 0270-7306
Lee, Youngsoo, Katyal, Sachin, Li, Yang, El-Khamisy, Sherif F, Russell, Helen R, Caldecott, Keith W and McKinnon, Peter J (2009) The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nature Neuroscience, 12 (8). 973-U35. ISSN 1097-6256
Dungey, Fiona A, Caldecott, Keith W and Chalmers, Anthony J (2009) Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics, 8 (8). pp. 2243-2254. ISSN 1535-7163
Dungey, Fiona A, Caldecott, Keith W and Chalmers, Anthony J (2009) Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics, 8 (8). pp. 2243-2254. ISSN 1535-7163
El-Khamisy, Sherif F, Katyal, Sachin, Patel, Poorvi, Ju, Limei, McKinnon, Peter J and Caldecott, Keith W (2009) Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair, 8 (6). pp. 760-766. ISSN 1568-7864
Reynolds, John J, El-Khamisy, Sherif F, Katyal, Sachin, Clements, Peter, McKinnon, Peter J and Caldecott, Keith W (2009) Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Molecular and Cellular Biology, 29 (5). pp. 1354-1362. ISSN 0270-7306
Caldecott, Keith (2008) Single-strand break repair and genetic disease. Nature Reviews Genetics, 9 (8). pp. 619-631. ISSN 0028-0836
Rulten, Stuart L, Cortes-Ledesma, Felipe, Guo, Liandi, Iles, Natasha J and Caldecott, Keith W (2008) APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Molecular and Cellular Biology, 28 (14). pp. 4620-4628. ISSN 0270-7306
Caldecott, Keith W (2008) Preface. DNA Repair, 7 (7). p. 1009. ISSN 1568-7864
Caldecott, Keith (2008) Special Issue - DNA damage responses and neurological disease - Preface. DNA Repair, 7 (7). p. 1009. ISSN 15687864
Petermann, Eva, Helleday, Thomas and Caldecott, Keith W (2008) Claspin promotes normal replication fork rates in human cells. Molecular Biology of the Cell, 19 (6). pp. 2373-2378. ISSN 1059-1524
Katyal, Sachin, El-Khamisy, Sherif F, Russell, Helen R, Liu, Yang, Ju, Limei, Caldecott, Keith W and McKinnon, Peter J (2007) TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO Journal, 26. pp. 4720-4731. ISSN 0261-4189
El-Khamisy, Sherif F, Hartsuiker, Edgar and Caldecott, Keith W (2007) TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. DNA Repair, 6 (10). pp. 1485-1495. ISSN 1568-7864
Mani, Rajam S, Fanta, Mesfin, Karimi-Busheri, Feridoun, Silver, Elizabeth, Virgen, César A, Caldecott, Keith W, Cass, Carol E and Weinfeld, Michael (2007) XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates. Journal of Biological Chemistry, 282 (38). pp. 28004-28013. ISSN 0021-9258
Moser, Jill, Kool, Hanneke, Giakzidis, Ioannis, Caldecott, Keith, Mullenders, Leon H F and Fousteri, Maria I (2007) Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. Molecular and Cellular Biology, 27 (2). pp. 311-323. ISSN 0270-7306
Maya-Mendoza, Apolinar, Petermann, Eva, Gillespie, David A F, Caldecott, Keith W and Jackson, Dean A (2007) Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO Journal, 26 (11). pp. 2719-2731. ISSN 0261-4189
Iles, Natasha, Rulten, Stuart, El-Khamisy, Sherif F and Caldecott, Keith W (2007) APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Molecular and Cellular Biology, 27 (10). pp. 3793-3803. ISSN 0270-7306
El-Khamisy, S F and Caldecott, K W (2007) DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. Neuroscience, 145 (4). pp. 1260-1266. ISSN 0306-4522
Caldecott, Keith (2007) Mammalian single-strand break repair: mechanisms and links with chromatin. DNA Repair, 6 (4: Rep). pp. 443-453. ISSN 1568-7864
Caldecott, Keith (2007) Mammalian Single-Strand Break Repair; Mechanisms and Links with Chromatin. DNA Repair, 6 (4). pp. 443-453. ISSN 1568-7864
Fisher, Anna E O, Hochegger, Helfrid, Takeda, Shunichi and Caldecott, Keith W (2007) Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase. Molecular and Cellular Biology, 27 (15). pp. 5597-5605. ISSN 0270-7306
Ahel, Ivan, Rass, Ulrich, El-Khamisy, Sherif F, Katyal, Sachin, Clements, Paula M, McKinnon, Peter J, Caldecott, Keith W and West, Stephen C (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature, 443. pp. 713-716. ISSN 0028-0836
Petermann, Eva and Caldecott, Keith W (2006) Evidence that the ATR/Chk 1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle, 5 (19). pp. 2203-2209. ISSN 1551-4005
El-Khamisy, Sherif F and Caldecott, Keith W (2006) TDP1-dependent DNA single-strand break repair and neurodegeneration. Mutagenesis, 21 (4). pp. 219-224. ISSN 0267-8357
Petermann, Eva, Maya-Mendoza, Apolinar, Zachos, George, Gillespie, David A F, Jackson, Dean A and Caldecott, Keith W (2006) Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase. Molecular and Cellular Biology, 26 (8). pp. 3319-3326. ISSN 0270-7306
Breslin, Claire, Clements, Paula M, El-Khamisy, Sherif F, Petermann, Eva, Iles, Natasha and Caldecott, Keith W (2006) Measurement of chromosomal DNA single-strand breaks and replication fork progression rates. Methods in Enzymology, 409. pp. 410-425. ISSN 0076-6879
El-Khamisy, Sherif F, Saifi, Gulam M, Weinfeld, Michael, Johansson, Fredrik, Helleday, Thomas, Lupski, James R and Caldecott, Keith W (2005) Defective DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. Nature, 434. pp. 108-113. ISSN 0306-4522
El-Khamisy, Sherif F, Saifi, Gulam M, Weinfeld, Michael, Johansson, Fredrik, Helleday, Thomas, Lupski, James R and Caldecott, Keith W (2005) Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature, 434. pp. 108-113. ISSN 0028-0836
Caldecott, Keith and Chalmers, A. (2005) An Achilles' heel for breast cancer? Nature Structural and Molecular Biology, 12 (5). pp. 387-388. ISSN 1545-9993
Mani, Rajam S, Karimi-Busheri, Feridoun, Fanta, Mesfin, Caldecott, Keith W, Cass, Carol E and Weinfeld, Michael (2004) Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA. Biochemistry, 43 (51). pp. 16505-16514. ISSN 0006-2960
Caldecott, Keith (2004) DNA single-strand breaks and neurodegeneration. DNA Repair, 3 (8-9). pp. 875-882. ISSN 1568-7864
Dianova, Irina I, Sleeth, Kate M, Allinson, Sarah L, Parsons, Jason L, Breslin, Claire, Caldecott, Keith W and Dianov, Grigory L (2004) XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. Nucleic Acids Research, 32 (8). pp. 2550-2555. ISSN 0305-1048
Loizou, Joanna I, El-Khamisy, Sherif F, Zlatanou, Anastasia, Moore, David J, Chan, Douglas W, Qin, Jun, Sarno, Stefania, Meggio, Flavio, Pinna, Lorenzo A and Caldecott, Keith W (2004) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell, 117 (1). pp. 17-28. ISSN 0092-8674
Clements, Paula M, Breslin, Claire, Deeks, Emma D, Byrd, Philip J, Ju, Limei, Bieganowski, Pawel, Brenner, Charles, Moreira, Maria-Céu, Taylor, A Malcolm R and Caldecott, Keith W (2004) The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. DNA Repair, 3 (11). pp. 1493-1502. ISSN 1568-7864
Caldecott, Keith (2003) Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions. DNA Repair, 2 (10). pp. 1087-1100. ISSN 1568-7864
Caldecott, Keith (2003) Cell signaling: The BRCT domain: signaling with friends? Science, 302 (5645). pp. 579-580. ISSN 0036-8075
Nakamura, Jun, Asakura, Shoji, Hester, Susan D, de Murcia, Gilbert, Caldecott, Keith W and Swenberg, James A (2003) Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic Acids Research, 31 (17). e104-e104. ISSN 0305-1048
Caldecott, Keith (2003) XRCC1 and DNA strand break repair. DNA Repair, 2 (9). pp. 955-969. ISSN 1568-7864
Henry-Mowatt, Judith, Jackson, Dean, Masson, Jean-Yves, Johnson, Penny A, Clements, Paula M, Benson, Fiona E, Thompson, Larry H, Takeda, Shunichi, West, Stephen C and Caldecott, Keith W (2003) XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Molecular Cell, 11 (4). pp. 1109-1117. ISSN 1097-2765
Caldecott, Keith (2003) A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Research, 31 (19). pp. 5526-5533. ISSN 0305-1048
Caldecott, Keith (2003) DNA single-strand break repair and spinocerebellar ataxia. Cell, 112 (1). pp. 7-10. ISSN 0092-8674
Caldecott, Keith (2003) Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions, 31 (1). pp. 247-251. ISSN 0300-5127
Okano, Satoshi, Lan, Li, Caldecott, Keith W, Mori, Toshio and Yasui, Akira (2003) Spatial and temporal cellular responses to single-strand breaks in human cells. Molecular and Cellular Biology, 23 (11). pp. 3974-3981. ISSN 1098-5549
Taylor, Richard M, Thistlethwaite, Angela and Caldecott, Keith W (2002) Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair. Molecular and Cellular Biology, 22 (8). 2556-2563.. ISSN 0270-7306
Iftner, Thomas, Elbel, Michaela, Schopp, Betti, Hiller, Thomas, Loizou, Joanna I, Caldecott, Keith W and Stubenrauch, Frank (2002) Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1. EMBO Journal, 21 (17). pp. 4741-4748. ISSN 0261-4189
Caldecott, K.W. (2002) Polynucleotide kinase. A versatile molecule makes a clean break. Structure, 10 (9). pp. 1151-1152. ISSN 0969-2126
Caldecott, Keith (2001) Mammalian DNA single-strand break repair: an X-ra(y)ted affair. BioEssays, 23 (5). pp. 447-455. ISSN 0265-9247
Whitehouse, Claire J, Taylor, Richard M, Thistlethwaite, Angela, Zhang, Hong, Karimi-Busheri, Feridoun, Lasko, Dana D, Weinfeld, Michael and Caldecott, Keith W (2001) XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell, 104 (1). pp. 107-117. ISSN 0092-8674
Book Section
Rulten, Stuart L, Dantzer, Francoise and Caldecott, Keith W (2015) The role of PARPs in DNA strand break repair. In: Curtin, Nicola J and Sharma, Ricky A (eds.) PARP Inhibitors for Cancer Therapy. Cancer Drug Discovery and Development, 83 . Humana Press, New York, pp. 47-78. ISBN 9783319141503
Conference or Workshop Item
Reynolds, John J, El-Khamisy, Sherif F and Caldecott, Keith W (2009) Short-patch single-strand break repair in ataxia oculomotor apraxia-1. In: Symposium on DNA Damage - From Causes to Cures Univ Cambridge, Robinson Coll, Cambridge, ENGLAND, DEC 15-17, 2008, Cambridge, ENGLAND.