Items for Prodromou, Chrisostomos

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Blundell, Katie L I M, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2017) The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. PLoS ONE, 12 (3). e0173543. ISSN 1932-6203

Prodromou, Chrisostomos (2017) Regulatory mechanisms of Hsp90. Biochemistry and Molecular Biology Journal, 3 (1). pp. 1-8. ISSN 2471-8084

Prodromou, Chrisostomos (2016) Mechanisms of Hsp90 regulation. Biochemical Journal, 473 (16). pp. 2439-2452. ISSN 1470-8728

Hernández-Ramírez, Laura C, Martucci, Federico, Morgan, Rhodri M L, Trivellin, Giampaolo, Tilley, Daniel, Ramos-Guajardo, Nancy, Iacovazzo, Donato, D'Acquisto, Fulvio, Prodromou, Chrisostomos and Korbonits, Márta (2016) Rapid proteasomal degradation of mutant proteins is the primary mechanism leading to tumorigenesis in patients with missense AIP mutations. The Journal of clinical endocrinology and metabolism, 101 (8). 3144 -3154. ISSN 1945-7197

Kasza, Ágnes, Hunya, Ákos, Frank, Zsuzsa, Fülöp, Ferenc, Török, Zsolt, Balogh, Gábor, Sántha, Miklós, Bálind, Árpád, Bernáth, Sándor, Blundell, Katie L I M, Prodromou, Chrisostomos, Horváth, Ibolya, Zeiler, Hans-Joachim, Hooper, Philip L, Vigh, László and Penke, Botond (2016) Dihydropyridine derivatives modulate heat shock responses and have a neuroprotective effect in a transgenic mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 53 (2). pp. 557-571. ISSN 1387-2877

Woodford, Mark R, Dunn, Diana M, Bladen, Adam R, Capriotti, Dante, Loiselle, David, Prodromou, Chrisostomos, Panaretou, Barry, Hughes, Philip F, Smith, Aaron, Ackerman, Wendi, Haystead, Timothy A, Loh, Stewart N, Bourboulia, Dimitra, Schmidt, Laura S, Linehan, W Marston, Bratslavsky, Gennady and Mollapour, Mehdi (2016) The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nature Communications, 7. p. 12037. ISSN 2041-1723

Woodford, Mark R, Truman, Andrew W, Dunn, Diana M, Jensen, Sandra M, Cotran, Richard, Bullard, Renee, Abouelleil, Mourad, Beebe, Kristin, Wolfgeher, Donald, Wierzbicki, Sara, Post, Dawn E, Caza, Tiffany, Tsutsumi, Shinji, Panaretou, Barry, Kron, Stephen J, Trepel, Jane B, Landas, Steve, Prodromou, Chrisostomos, Shapiro, Oleg, Stetler-Stevenson, William G, Bourboulia, Dimitra, Neckers, Len, Bratslavsky, Gennady and Mollapour, Mehdi (2016) Mps1 mediated phosphorylation of Hsp90 confers renal cell carcinoma sensitivity and selectivity to Hsp90 inhibitors. Cell Reports, 14 (4). pp. 872-884. ISSN 2211-1247

Dunn, Diana M, Woodford, Mark R, Truman, Andrew W, Jensen, Sandra M, Schulman, Jacqualyn, Caza, Tiffany, Remillard, Taylor C, Loiselle, David, Wolfgeher, Donald, Blagg, Brian S J, Franco, Lucas, Haystead, Timothy A, Daturpalli, Soumya, Mayer, Matthias P, Trepel, Jane B, Morgan, Rhodri M L, Prodromou, Chrisostomos, Kron, Stephen J, Panaretou, Barry, Stetler-Stevenson, William G, Landas, Steve K, Neckers, Len, Bratslavsky, Gennady, Bourboulia, Dimitra and Mollapour, Mehdi (2015) c-Abl mediated tyrosine phosphorylation of Aha1 activates its co-chaperone function in cancer cells. Cell Reports, 12 (6). pp. 1006-1018. ISSN 2211-1247

Morgan, Rhodri M L, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2015) Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Acta Crystallographica Section D: Biological Crystallography, D71. pp. 1197-1206. ISSN 1399-0047

Pal, Mohinder, Morgan, Marc, Phelps, Sarah E L, Roe, S Mark, Parry-Morris, Sarah, Downs, Jessica, Polier, Sigrun, Pearl, Laurence and Prodromou, Chrisostomos (2014) Structural basis for phosphorylation-dependent recruitment of tel2 to hsp90 by pih1. Structure, 22 (6). pp. 805-818. ISSN 1878-4186

Mollapour, Mehdi, Bourboulia, Dimitra, Beebe, Kristin, Woodford, Mark R, Polier, Sigrun, Hoang, Anthony, Chelluri, Raju, Li, Yu, Guo, Ailan, Lee, Min-Jung, Fotooh-Abadi, Elham, Khan, Sahar, Prince, Thomas, Miyajima, Naoto, Yoshida, Soichiro, Tsutsumi, Shinji, Xu, Wanping, Panaretou, Barry, Stetler-Stevenson, William G, Bratslavsky, Gennady, Trepel, Jane B, Prodromou, Chrisostomos and Neckers, Len (2014) Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors. Molecular Cell, 53 (2). pp. 317-329. ISSN 1097-2765

Dutton, Bridie L, Kitson, Russell R A, Parry-Morris, Sarah, Roe, S Mark, Prodromou, Chrisostomos and Moody, Chrisostomos (2014) Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Organic and Biomolecular Chemistry, 12 (8). pp. 1328-1340. ISSN 1477-0520

Smith, J R, de Billy, E, Hobbs, S, Powers, M, Prodromou, C, Pearl, L, Clarke, P A and Workman, P (2013) Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. Oncogene, 34 (1). pp. 15-26. ISSN 0950-9232

Kitson, Russell R A, Chang, Chuan-Hsin, Xiong, Rui, Williams, Huw E L, Davis, Adrienne L, Lewis, William, Dehn, Donna L, Siegel, David, Roe, S Mark, Prodromou, Chrisostomos, Ross, David and Moody, Christopher J (2013) Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nature Chemistry, 5 (4). pp. 307-314. ISSN 1755-4330

Polier, Sigrun, Samant, Rahul S, Clarke, Paul A, Workman, Paul, Prodromou, Chrisostomos and Pearl, Laurence H (2013) ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nature Chemical Biology, 9 (5). pp. 307-312. ISSN 1552-4450

Morgan, Rhodri M L, Hernández-Ramírez, Laura C, Trivellin, Giampaolo, Zhou, Lihong, Roe, S Mark, Korbonits, Márta and Prodromou, Chrisostomos (2012) Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PLoS ONE, 7 (12). e53339. ISSN 1932-6203

Truman, Andrew W, Kristjansdottir, Kolbrun, Wolfgeher, Donald, Hasin, Naushaba, Polier, Sigrun, Zhang, Hong, Perrett, Sarah, Prodromou, Chrisostomos, Jones, Gary W and Kron, Stephen J (2012) CDK-dependent Hsp70 phosphorylation controls G1 cyclin abundance and cell-cycle progression. Cell, 151 (6). pp. 1308-1318. ISSN 0092-8674

Xu, Wanping, Mollapour, Mehdi, Prodromou, Chrisostomos, Wang, Suiquan, Scroggins, Bradley T, Palchick, Zach, Beebe, Kristin, Siderius, Marco, Lee, Min-Jung, Couvillon, Anthony, Trepel, Jane B, Miyata, Yoshihiko, Matts, Robert and Neckers, Len (2012) Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Molecular Cell, 47 (3). pp. 434-443. ISSN 1097-2765

Prodromou, Chrisostomos (2012) The 'active life' of Hsp90 complexes. BBA - Molecular Cell Research, 1823 (3). pp. 614-623. ISSN 0006-3002

Tsutsumi, Shinji, Mollapour, Mehdi, Prodromou, Chrisostomos, Lee, Chung-Tien, Panaretou, Barry, Yoshida, Soichiro, Mayer, Matthias P and Neckers, Leonard M (2012) Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. Proceedings of the National Academy of Sciences, 109 (8). pp. 2937-2942. ISSN 1091-6490

Sharp, Swee Y, Roe, S Mark, Kazlauskas, Egidijus, Čikotienė, Inga, Workman, Paul, Matulis, Daumantas and Prodromou, Chrisostomos (2012) Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. PLoS Genetics, 7(9) (e44642). ISSN 1553-7390

Day, James E H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Hayes, Angela, Raynaud, Florence I, Lewis, William, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2011) Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. ACS Chemical Biology, 6 (12). pp. 1339-1347. ISSN 1554-8929

Millson, Stefan H, Chua, Chun-Song, Roe, S Mark, Polier, Sigrun, Solovieva, Svetlana, Pearl, Laurence H, Sim, Tiow-Suan, Prodromou, Chrisostomos and Piper, Peter W (2011) Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. FASEB Journal, 25 (11). pp. 3828-3837. ISSN 0892-6638

Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W, Xu, Wanping, Vaughan, Cara K, Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W, Trepel, Jane B, Prodromou, Chrisostomos, Pearl, Laurence H and Neckers, Len (2011) Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Molecular Cell, 41 (6). pp. 672-681. ISSN 1097-2765

Maclagan, Kate, Tommasi, Rita, Laurine, Emmanuelle, Prodromou, Chrisostomos, Driscoll, Paul C, Pearl, Laurence H, Reich, Stefanie and Savva, Renos (2011) A combinatorial method to enable detailed investigation of protein–protein interactions. Future Medicinal Chemistry, 3 (3). pp. 271-282. ISSN 1756-8919

Day, James E H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Lewis, William, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2010) Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Chemistry - A European Journal, 16 (34). pp. 10366-10372. ISSN 0947-6539

Zhang, Minghao, Kadota, Yasuhiro, Prodromou, Chrisostomos, Shirasu, Ken and Pearl, Laurence H (2010) Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Molecular Cell, 39 (2). pp. 269-281. ISSN 1097-2765

Millson, Stefan H., Prodromou, Chrisostomos and Piper, Peter W. (2010) A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta. Biochemical Pharmacology, 79 (11). pp. 1581-1588. ISSN 0006-2952

Mollapour, Mehdi, Tsutsumi, Shinji, Donnelly, Alison C, Beebe, Kristin, Tokita, Mari J, Lee, Min-Jung, Lee, Sunmin, Morra, Giulia, Bourboulia, Dimitra, Scroggins, Bradley T, Colombo, Giorgio, Blagg, Brian S, Panaretou, Barry, Stetler-Stevenson, William G, Trepel, Jane B, Piper, Peter W, Prodromou, Chrisostomos, Pearl, Laurence H and Neckers, Len (2010) Swe1(Wee1)-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function. Molecular Cell, 37 (3). pp. 333-343. ISSN 1097-2765

Rowlands, Martin, McAndrew, Craig, Prodromou, Chris, Pearl, Laurence, Kalusa, Andrew, Jones, Keith, Workman, Paul and Aherne, Wynne (2010) Detection of the ATPase Activity of the Molecular Chaperones Hsp90 and Hsp72 Using the Transcreener™ ADP Assay Kit. Journal of Biomolecular Screening, 15 (3). pp. 279-86. ISSN 1087-0571

Tsutsumi, Shinji, Mollapour, Mehdi, Graf, Christian, Lee, Chung-Tien, Scroggins, Bradley T, Xu, Wanping, Haslerova, Lenka, Hessling, Martin, Konstantinova, Anna A, Trepel, Jane B, Panaretou, Barry, Buchner, Johannes, Mayer, Matthias P, Prodromou, Chrisostomos and Neckers, Len (2009) Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain. Nature Structural and Molecular Biology, 16 (11). pp. 1141-1147. ISSN 1545-9993

Prodromou, Chrisostomos (2009) Strategies for Stalling Malignancy: Targeting Cancer's Addiction to Hsp90. Current Topics in Medicinal Chemistry, 9 (15). pp. 1352-1368. ISSN 1568-0266

Nilapwar, Sanjay, Williams, Eleanor, Fu, Christopher, Prodromou, Chrisostomos, Pearl, Laurence H, Williams, Mark A and Ladbury, John E (2009) Structural–Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90. Journal of Molecular Biology, 392 (4). pp. 923-936. ISSN 0022-2836

Prodromou, Chrisostomos, Nuttall, James M, Millson, Stefan H, Roe, S Mark, Sim, Tiow-Suan, Tan, Doreen, Workman, Paul, Pearl, Laurence H and Piper, Peter W (2009) Structural basis of the radicicol resistance displayed by a fungal hsp90. ACS Chemical Biology, 4 (4). pp. 289-297. ISSN 1554-8929

Mayer, Matthias P, Prodromou, Chrisostomos and Frydman, Judith (2009) The Hsp90 mosaic: a picture emerges. Nature Structural and Molecular Biology, 16 (1). pp. 2-6. ISSN 1545-9993

Vaughan, Cara K, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2009) A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. FEBS Journal, 276 (1). pp. 199-209. ISSN 1742-464X

Zhang, Minghao, Botër, Marta, Li, Kuoyu, Kadota, Yasuhiro, Panaretou, Barry, Prodromou, Chrisostomos, Shirasu, Ken and Pearl, Laurence H (2008) Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. EMBO Journal, 27 (20). pp. 2789-2798. ISSN 0261-4189

Vaughan, Cara K, Mollapour, Mehdi, Smith, Jennifer R, Truman, Andrew, Hu, Bin, Good, Valerie M, Panaretou, Barry, Neckers, Len, Clarke, Paul A, Workman, Paul, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2008) Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molecular Cell, 31 (6). pp. 886-895. ISSN 1097-2765

Millson, Stefan H, Vaughan, Cara K, Zhai, Chao, Ali, Maruf M U, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2008) Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochemical Journal, 413. pp. 261-268. ISSN 0264-6021

Brough, Paul A., Pearl, Laurence H., Prodromou, Chrisostomos and et al, (2008) 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. Journal of Medicinal Chemistry, 51 (2). pp. 196-218. ISSN 0022-2623

Eccles, Suzanne A, Massey, Andy, Raynaud, Florence I, Sharp, Swee Y, Box, Gary, Valenti, Melanie, Patterson, Lisa, de Haven Brandon, Alexis, Gowan, Sharon, Boxall, Frances, Aherne, Wynne, Rowlands, Martin, Hayes, Angela, Martins, Vanessa, Urban, Frederique, Boxall, Kathy, Prodromou, Chrisostomos, Pearl, Laurence, James, Karen, Matthews, Thomas P, Cheung, Kwai-Ming, Kalusa, Andrew, Jones, Keith, McDonald, Edward, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Dymock, Brian, Drysdale, Martin J, Finch, Harry, Howes, Rob, Hubbard, Roderick E, Surgenor, Alan, Webb, Paul, Wood, Mike, Wright, Lisa and Workman, Paul (2008) NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Research, 68 (8). pp. 2850-2860. ISSN 0008-5472

Martin, Christine J, Gaisser, Sabine, Challis, Iain R, Carletti, Isabelle, Wilkinson, Barrie, Gregory, Matthew, Prodromou, Chrisostomos, Roe, S Mark, Pearl, Laurence H, Boyd, Susan M and Zhang, Ming-Qiang (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. Journal of Medicinal Chemistry, 51 (9). pp. 2853-2857. ISSN 0022-2623

Pearl, Laurence H, Prodromou, Chrisostomos and Workman, Paul (2008) The Hsp90 molecular chaperone: an open and shut case for treatment. Biochemical Journal, 410. pp. 439-453. ISSN 0264-6021

Hawkins, Thomas A, Haramis, Anna-Pavlina, Etard, Christelle, Prodromou, Chrisostomos, Vaughan, Cara K, Ashworth, Rachel, Ray, Saikat, Behra, Martine, Holder, Nigel, Talbot, William S, Pearl, Laurence H, Strähle, Uwe and Wilson, Stephen W (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development, 135 (6). pp. 1147-1156. ISSN 0950-1991

Zhang, Ming-Qiang, Gaisser, Sabine, Nur-E-Alam, Mohammad, Sheehan, Lesley S, Vousden, William A, Gaitatzis, Nikolaos, Peck, Gerrard, Coates, Nigel J, Moss, Steven J, Radzom, Markus, Foster, Teresa A, Sheridan, Rose M, Gregory, Matthew A, Roe, Susan M, Prodromou, Chrisostomos, Pearl, Laurence, Boyd, Susan M, Wilkinson, Barrie and Martin, Christine J (2008) Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. Journal of Medicinal Chemistry, 51 (18). pp. 5494-5497. ISSN 0022-2623

Savva, Renos, Prodromou, Chrisostomos and Driscoll, Paul C (2007) DNA fragmentation based combinatorial approaches to soluble protein expression Part II: library expression, screening and scale-up. Drug Discovery Today, 12 (21-22). pp. 939-947. ISSN 1359-6446

Sharp, Swee Y, Prodromou, Chrisostomos, Boxall, Kathy, Powers, Marissa V, Holmes, Joanna L, Box, Gary, Matthews, Thomas P, Cheung, Kwai-Ming J, Kalusa, Andrew, James, Karen, Hayes, Angela, Hardcastle, Anthea, Dymock, Brian, Brough, Paul A, Barril, Xavier, Cansfield, Julie E, Wright, Lisa, Surgenor, Allan, Foloppe, Nicolas, Hubbard, Roderick E, Aherne, Wynne, Pearl, Laurence, Jones, Keith, McDonald, Edward, Raynaud, Florence, Eccles, Sue, Drysdale, Martin and Workman, Paul (2007) Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Molecular Cancer Therapeutics, 6 (4). pp. 1198-1211. ISSN 1535-7163

Prodromou, Chrisostomos, Savva, Renos and Driscoll, Paul C (2007) DNA fragmentation-based combinatorial approaches to soluble protein expression: Part I. Generating DNA fragment libraries. Drug Discovery Today, 12 (21-22). pp. 931-938. ISSN 1359-6446

Truman, Andrew W, Millson, Stefan H, Nuttall, James M, Mollapour, Mehdi, Prodromou, Chrisostomos and Piper, Peter W (2007) In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity. Eukaryotic Cell, 6 (4). pp. 744-752. ISSN 1535-9778

Sharp, Swee Y, Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A, Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thomas P, Cheung, Kwai-Ming J, Ball, Karen, Hayes, Angela, Raynaud, Florence, Marais, Richard, Pearl, Laurence, Eccles, Sue, Aherne, Wynne, McDonald, Edward and Workman, Paul (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Research, 67 (5). pp. 2206-2216. ISSN 0008-5472

Truman, Andrew W, Millson, Stefan H, Nuttall, James M, King, Victoria, Mollapour, Medhi, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2006) Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryotic Cell, 5 (11). pp. 1914-1924. ISSN 1535-9778

Proisy, Nicolas, Sharp, Swee Y, Boxall, Kathy, Connelly, Stephen, Roe, S Mark, Prodromou, Chrisostomos, Slawin, Alexandra M Z, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2006) Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chemistry and Biology, 13 (11). pp. 1203-1215. ISSN 1074-5521

Pearl, Laurence H and Prodromou, Chrisostomos (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. Annual Review of Biochemistry, 75. pp. 271-294. ISSN 0066-4154

Ali, Maruf M U, Roe, S Mark, Vaughan, Cara K, Meyer, Phillipe, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2006) Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature, 440. pp. 1013-1017. ISSN 0028-0836

Reich, Stephanie, Puckey, Loretto H, Cheetham, Caroline L, Harris, Richard, Ali, Ammar A E, Bhattacharyya, Uma, Maclagan, Kate, Powell, Keith A, Prodromou, Chrisostomos, Pearl, Laurence H, Driscoll, Paul C and Savva, Renos (2006) Combinatorial domain hunting: an effective approach for the identification of soluble protein domains adaptable to high-throughput applications. Protein Science, 15 (10). pp. 2356-2365. ISSN 0961-8368

Vaughan, Cara K, Gohlke, Ulrich, Sobott, Frank, Good, Valerie M, Ali, Maruf M U, Prodromou, Chrisostomos, Robinson, Carol V, Saibil, Helen R and Pearl, Laurence H (2006) Structure of an Hsp90-Cdc37-Cdk4 complex. Molecular Cell, 23 (5). pp. 697-707. ISSN 1097-2765

Zhang, Minghao, Windheim, Mark, Roe, S Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos and Pearl, Laurence H (2005) Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Molecular Cell, 20 (4). pp. 525-538. ISSN 1097-2765

Cheung, Kwai-Ming J, Matthews, Thomas P, James, Karen, Rowlands, Martin G, Boxall, Katherine J, Sharp, Swee Y, Maloney, Alison, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Aherne, G Wynne, McDonald, Edward and Workman, Paul (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorganic and Medicinal Chemistry Letters, 15 (14). pp. 3338-3343. ISSN 0960-894X

Millson, Stefan H, Truman, Andrew W, King, Victoria, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2005) A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Eukaryotic Cell, 4 (5). pp. 849-860. ISSN 1535-9778

Hu, Bin, Liao, Chunyan, Millson, Stefan H, Mollapour, Mehdi, Prodromou, Chrisostomos, Pearl, Laurence H, Piper, Peter W and Panaretou, Barry (2005) Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Molecular Microbiology, 55 (6). pp. 1735-1750. ISSN 0950-382X

Siligardi, Giuliano, Hu, Bin, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2004) Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. Journal of Biological Chemistry, 279 (50). pp. 51989-51998. ISSN 0021-9258

Rowlands, Martin G, Newbatt, Yvette M, Prodromou, Chrisostomos, Pearl, Laurence, Workman, Paul and Aherne, Wynne (2004) High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Analytical Biochemistry, 327 (2). pp. 176-183. ISSN 0003-2697

Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23 (6). pp. 1402-1410. ISSN 0261-4189

Roe, S Mark, Ali, Maruf M U, Meyer, Philippe, Vaughan, Cara K, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2004) The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell, 116 (1). pp. 87-98. ISSN 0092-8674

Millson, Stefan H, Truman, Andrew W, Wolfram, Francis, King, Victoria, Panaretou, Barry, Prodromou, Chrisostomos, Pearl, Laurence H and Piper, Peter W (2004) Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach. Cell Stress and Chaperones, 9 (4). pp. 359-368. ISSN 1355-8145

Piper, Peter W, Millson, Stefan H, Mollapour, Mehdi, Panaretou, Barry, Siligardi, Giuliano, Pearl, Laurence H and Prodromou, Chrisostomos (2003) Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. European Journal of Biochemistry, 270 (23). pp. 4689-4695. ISSN 0014-2956

Prodromou, Chrisostomos and Pearl, Laurence H (2003) Structure and functional relationships of Hsp90. Current Cancer Drug Targets, 3 (5). pp. 301-323. ISSN 1568-0096

Meyer, Philipe, Prodromou, Chrisostomos, Hu, Bin, Vaughan, Cara, Roe, S Mark, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2003) Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Molecular Cell, 11 (3). pp. 647-658. ISSN 1097-2765

Piper, Peter W, Panaretou, Barry, Millson, Stefan H, Truman, Andrew, Mollapour, Mehdi, Pearl, Laurence and Prodromou, Chrisostomos (2003) Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. Gene, 302 (1-2). pp. 165-170. ISSN 0378-1119

Aherne, Wynne, Maloney, Alison, Prodromou, Chrisostomos, Rowlands, Martin G, Hardcastle, Anthea, Boxall, Katherine, Clarke, Paul, Walton, Michael I, Pearl, Laurence and Workman, Paul (2003) Assays for HSP90 and inhibitors. Methods in Molecular Medicine, 85. pp. 149-161. ISSN 1543-1894

Panaretou, Barry, Siligardi, Giuliana, Meyer, Philippe, Maloney, Alison, Sullivan, Janis K, Singh, Shradha, Millson, Stefan H, Clarke, Paul A, Naaby-Hansen, Soren, Stein, Rob, Cramer, Rainer, Mollapour, Mehdi, Workman, Paul, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2002) Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Molecular Cell, 10 (6). pp. 1307-1318. ISSN 1097-2765

Salek, Reza M, Williams, Mark A, Prodromou, Chrisostomos, Pearl, Laurence H and Ladbury, John E (2002) Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone. Journal of Biomolecular NMR, 23 (4). pp. 327-328. ISSN 0925-2738

Siligardi, Giuliano, Panaretou, Barry, Meyer, Philippe, Singh, Shradha, Woolfson, Derek N, Piper, Peter W, Pearl, Laurence H and Prodromou, Chrisostomos (2002) Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. Journal of Biological Chemistry, 277 (23). pp. 20151-20159. ISSN 0021-9258

Pearl, Laurence H and Prodromou, Chrisostomos (2001) Structure, function, and mechanism of the Hsp90 molecular chaperone. Advances in Protein Chemistry, 59. pp. 157-186. ISSN 0065-3233

Pearl, Laurence H and Prodromou, Chrisostomos (2000) Structure and in vivo function of Hsp90. Current Opinion in Structural Biology, 10 (1). pp. 46-51. ISSN 0959-440X

Prodromou, Chrisostomos, Panaretou, Barry, Chohan, Shahzad, Siligardi, Giuliano, O'Brien, Ronan, Ladbury, John E, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (2000) The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO Journal, 19 (16). pp. 4383-92. ISSN 0261-4189

Panaretou, Barry, Sinclair, Kirsty, Prodromou, Chrisostomos, Johal, Jasvinder, Pearl, Laurence and Piper, Peter W (1999) The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections. Microbiology, 145 (12). pp. 3455-3463. ISSN 1350-0872

Roe, S Mark, Prodromou, Chrisostomos, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. Journal of Medicinal Chemistry, 42 (2). pp. 260-266. ISSN 0022-2623

Prodromou, Chrisostomos, Siligardi, Giuliano, O'Brien, Ronan, Woolfson, Derek N, Regan, Lynne, Panaretou, Barry, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO Journal, 18 (3). pp. 754-762. ISSN 0261-4189

Panaretou, Barry, Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1998) ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO Journal, 17 (16). pp. 4829-4836. ISSN 0261-4189

Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1997) Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell, 90 (1). pp. 65-75. ISSN 0092-8674

Prodromou, Chrisostomos, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (1997) A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nature Structural Biology, 4 (6). pp. 477-482. ISSN 1072-8368

Prodromou, Chrisostomos, Piper, Peter W and Pearl, Laurence H (1996) Expression and crystallization of the yeast Hsp82 chaperone, and preliminary X-ray diffraction studies of the amino-terminal domain. Proteins, 25 (4). pp. 517-522. ISSN 0887-3585

Wheeler, Vanessa C, Prodromou, Chrisostomos, Pearl, Laurence H, Williamson, Robert and Coutelle, Charles (1996) Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect. Gene, 169 (2). pp. 251-255. ISSN 0378-1119

Prodromou, Chrisostomos and Pearl, Laurence H (1992) Recursive PCR: a novel technique for total gene synthesis. Protein Engineering, Design and Selection, 5 (8). pp. 827-829. ISSN 1741-0126

Prodromou, Chrisostomos, Artymiuk, Peter J and Guest, John R (1992) The aconitase of Escherichia coli. Nucleotide sequence of the aconitase gene and amino acid sequence similarity with mitochondrial aconitases, the iron-responsive-element-binding protein and isopropylmalate isomerases. European Journal of Biochemistry, 204 (2). pp. 599-609. ISSN 0014-2956

Prodromou, Chrisostomos, Haynes, Megan J and Guest, John R (1991) The aconitase of Escherichia coli: purification of the enzyme and molecular cloning and map location of the gene (acn). Journal of General Microbiology, 137 (11). pp. 2505-2515. ISSN 0022-1287

Prodromou, C, Wright, I P, Evans, I H and Bevan, E A (1991) Cloning of the HIS3 gene of Yarrowia lipolytica. Antonie Van Leeuwenhoek, 60 (2). pp. 95-99. ISSN 0003-6072

Book Section

Prodromou, Chrisostomos and Morgan, Rhodri M L (2015) “Tuning” the ATPase activity of Hsp90. In: Chakraborti, Sajal and Dhalla, Naranjan S (eds.) Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Advances in biochemistry in health and disease, 14 . Springer, pp. 469-490. ISBN 9783319247786

This list was generated on Thu Apr 27 02:11:06 2017 BST.