Items for Ward, Simon

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Number of items: 37.

Article

Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553

Reuillon, Tristan, Ward, Simon and Beswick, Paul (2016) AMPA receptor positive allosteric modulators: potential for the treatment of neuropsychiatric and neurological disorders. Current Topics in Medicinal Chemistry, 16 (29). pp. 3536-3565. ISSN 1568-0266

Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021

Pearl, Laurence H, Schierz, Amanda C, Ward, Simon E, Al-Lazikani, Bissan and Pearl, Frances M G (2015) Therapeutic opportunities within the DNA damage response. Nature Reviews Cancer, 15. pp. 166-180. ISSN 1474-175X

Ward, Simon E, Pennicott, Lewis E and Beswick, Paul (2015) AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications. Future Medicinal Chemistry, 7 (4). pp. 473-491. ISSN 1756-8919

Ward, Simon E and Beswick, Paul (2014) What does the aromatic ring number mean for drug design? Expert Opinion on Drug Discovery, 9 (9). pp. 995-1003. ISSN 1746-0441

Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A, Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H, Pearl, Laurence H, Oliver, Antony W, El-Khamisy, Sherif, Ward, Simon and Atack, John R (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry, 454. pp. 17-22. ISSN 0003-2697

Ward, Simon E, Harries, Mark, Aldegheri, Laura, Austin, Nigel E and et al, (2011) Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators. Journal of Medicinal Chemistry, 54 (1). pp. 78-94. ISSN 0022-2623

Thewlis, Kevin M, Aldegheri, Laura, Harries, Mark H, Mookherjee, Claudette, Oliosi, Beatrice and Ward, Simon E (2010) N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7116-7119. ISSN 0960-894X

Ward, Simon E and Harries, Mark (2010) Recent Advances in the Discovery of Selective AMPA Receptor Positive Allosteric Modulators. Current Medicinal Chemistry, 17 (30). pp. 3503-3513. ISSN 1875-533X

Ward, Simon, Bax, Benjamin D and Harries, Mark (2010) Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology, 160 (2). pp. 181-190. ISSN 0007-1188

Ward, Simon E and Watson, Jeannette M (2010) Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands. Current Topics in Medicinal Chemistry, 10 (5). pp. 479-492. ISSN 1873-4294

Leslie, Colin P, Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M, Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J, Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarlo, Pizzi, Domenica A, Stasi, Luigi P, Tibasco, Jessica, Vong, Antonio, Ward, Simon E and Zonzini, Laura (2010) Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT(1A/B/D) Receptor Antagonist. Journal of Medicinal Chemistry, 53 (23). pp. 8228-8240. ISSN 0022-2623

Ward, Simon, Harries, M, Aldegheri, L, Andreotti, D and et al, (2010) Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator. Journal of Medicinal Chemistry, 53 (15). pp. 5801-5812. ISSN 0022-2623

Alderton, W, Karran, E and Ward, Simon (2009) Current and Future Perspectives in Psychiatric Drug Discovery. Drug news & perspectives, 22 (6). pp. 360-364. ISSN 0214-0934

Ward, Simon E, Eddershaw, Peter, Flynn, Sean T, Gordon, Laurie, Lovell, Peter J, Moore, Susan H, Scott, Claire M, Smith, Paul W, Thewlis, Kevin M and Wyman, Paul A (2009) Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II. Bioorganic and Medicinal Chemistry Letters, 19 (2). pp. 428-432. ISSN 0960-894X

Ward, Simon E, Eddershaw, Peter J, Scott, Claire M, Gordon, Laurie J, Lovell, Peter J, Moore, Susan H, Smith, Paul W, Starr, Kathryn R, Thewlis, Kevin M and Watson, Jeannette M (2008) Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. Journal of Medicinal Chemistry, 51 (10). pp. 2887-2890. ISSN 0022-2623

Ward, Simon (2008) Antagonists of the human adenosine A(2A) receptor. Part 1: Discovery and synthesis of thieno[3,2-d] pyrimidine-4-methanone derivatives. Bioorganic & Medicinal Chemistry Letters, 18 (9). pp. 2916-2919. ISSN 0960894X

Book Section

Ward, Simon (2014) AMPA receptor positive allosteric modulators – a case history. In: Cox, Brian and Gosling, Martin (eds.) Ion channel drug discovery. RSC drug discovery . Royal Society of Chemistry, pp. 105-134. ISBN 9781849731867

Edited Book

Davis, Andrew and Ward, Simon E, eds. (2014) The handbook of medicinal chemistry: principles and practice. Royal Society of Chemistry. ISBN 9781849736251

Patent

Gibbs, Ayana Alice; Ward, Simon Edward; Pennicott, Lewis Elliot (2013) Neurodevelopmental disorders. WO2012GB52278 20120914.

Convergence Pharmaceuticals Ltd; Beswick, Paul J; Gleave, Robert J; Hachisu, Shuji; Vile, Sadie; Bertheleme, Nicolas; Ward, Simon E (2012) Tetrazole compounds as calcium channel blockers. PCT/GB2011/051276.

Glaxo Group Ltd; Bradley, Daniel M; Cardullo, Francesca; Marshall, Howard; Marzorati, Paola; Pozzan, Alfonso; Ward, Simon E (2010) Compounds which potentiate the AMPA receptor and uses thereof in medicine. WO/2010/066658.

Glaxo Group Ltd; Coulton, Steven; Gilpin, Martin; Ward, Simon E (2010) N-inden-2-yl-isopropylsulfonamides as AMPA receptor potentiators. PCT/EP2009/065263.

Glaxo Group Ltd; Ward, Simon, E; Bertheleme, Nicolas (2010) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2009/062652.

Convergence Pharmaceuticals Ltd; Heer, Jag P; Norton, David; Ward, Simon E (2010) Pyrazolo [1, 5-A] pyrimidine derivatives. PCT/EP2009/059013.

Glaxo Group Ltd; Thewlis, Kevin M; Ward, Simon E (2009) Compounds which potentiate the AMPA receptor and uses thereof in medicine. PCT/EP2009/050607.

Glaxo Group Ltd; Thewlis, Kevin M; Ward, Simon E (2009) Compounds which potentiate the AMPA receptor and uses thereof in medicine. PCT/EP2009/050608.

Glaxo Group Ltd; Bertheleme, Nicolas; Chan, Wai N; Scott, Jacqueline S; Ward, Simon E (2009) Compounds which potentiate the AMPA receptor and uses thereof in medicine. PCT/EP2008/067681.

Glaxo Group Ltd; Chan, Wai N; Harrison, Stephen; Hughes, Owen R; Neesom, James K; Thewlis, Kevin M; Ward, Simon E. (2009) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/064407.

Glaxo Group Ltd; Chan, Wai N; Thewlis, Kevin M; Ward, Simon E (2009) Thiazoles which potentiate AMPA receptor and medicinal uses thereof. PCT/EP2008/064408.

Glaxo Group Ltd; Bradley, Daniel M; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/056961.

Glaxo Group Ltd; Bertheleme, Nicolas; Bradley, Daniel M; Cardullo, Francesca; Merlo, Giancarlo; Pozzan, Alfonso; Scott, Jaqueline S; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/053194.

Glaxo Group Ltd; Bradley, Daniel M; Chan, Wai N; Harrison, Stephen A; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/052906.

Glaxo Group Ltd; Bradley, Daniel M; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate glutamate receptor and uses thereof in medicine. PCT/GB2005/008562.

Glaxo Group Ltd; Bradley, Daniel M; Chan, Wai n; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2007/061794.

Glaxo Group Ltd; Bradley, Daniel M; Chan, Wai N; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/056971.

This list was generated on Wed May 24 11:41:32 2017 BST.