Article

Mitchell, Simon, Tsui, Rachel, Tan, Zhixin Cyrillus, Pack, Arran and Hoffmann, Alexander (2023) The NF-κB multidimer system model: a knowledge base to explore diverse biological contexts. Science Signaling, 16 (776). ISSN 1945-0877

Agnarelli, Alessandro, Mitchell, Simon, Caalim, Gillian, Wood, C David, Milton-Harris, Leanne, Chevassut, Timothy, West, Michelle J and Mancini, Erika J (2022) Dissecting the impact of bromodomain inhibitors on the IRF4-MYC oncogenic axis in multiple myeloma. Hematological Oncology, 40 (3). pp. 417-429. ISSN 0278-0232

Burley, Thomas A, Hesketh, Andrew, Bucca, Giselda, Kennedy, Emma, Ladikou, Eleni E, Towler, Benjamin P, Mitchell, Simon, Smith, Colin P, Fegan, Christopher, Johnston, Rosalynd, Pepper, Andrea and Pepper, Chris (2022) Elucidation of focal adhesion kinase as a modulator of migration and invasion and as a potential therapeutic target in chronic lymphocytic leukemia. Cancers, 14 (7). a1600 1-16. ISSN 2072-6694

Burley, Thomas A, Kennedy, Emma, Broad, Georgia, Boyd, Melanie, Li, David, Woo, Timothy, West, Christopher, Ladikou, Eleni E, Ashworth, Iona, Fegan, Christopher, Johnston, Rosalynd, Mitchell, Simon, Mackay, Simon P, Pepper, Andrea G S and Pepper, Chris (2022) Targeting the non-canonical NF-κB pathway in chronic lymphocytic leukemia and multiple myeloma. Cancers, 14 (6). a1489 1-17. ISSN 2072-6694

Samarasinghe, Ranmal A, Miranda, Osvaldo A, Buth, Jessie E, Mitchell, Simon, Ferando, Isabella, Watanabe, Momoko, Allison, Thomas F, Kurdian, Arinnae, Fotion, Namie N, Gandal, Michael J, Golshani, Peyman, Plath, Kathrin, Lowry, William E, Parent, Jack M, Mody, Istvan and Novitch, Bennett G (2021) Identification of neural oscillations and epileptiform changes in human brain organoids. Nature Neuroscience, 24. pp. 1488-1500. ISSN 1097-6256

Chang, Yu-Ling, Rossetti, Maura, Gjertson, David W, Rubbi, Liudmilla, Thompson, Michael, Montoya, Dennis J, Morselli, Marco, Ruffin, Felicia, Hoffmann, Alexander, Pellegrini, Matteo, Fowler, Vance G, Yeaman, Michael R, Reed, Elaine F, Mitchell, Simon, the MRSA Systems Immunology Group, and others, (2021) Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia. Proceedings of the National Academy of Sciences (PNAS), 118 (10). a2000663118 1-11. ISSN 0027-8424

Mitchell, Simon (2021) What will B will B: identifying molecular determinants of diverse B-cell fate decisions through systems biology. Frontiers in Cell and Developmental Biology, 8. a616592 1-8. ISSN 2296-634X

Kennedy, Emma, Coulter, Eve Marie, Halliwell, Emma, Profitos-Peleja, Nuria, Walsby, Elisabeth, Clark, Barnaby, Phillips, Elizabeth H, Burley, Thomas A, Mitchell, Simon, Devereux, Stephen, Jones, Christopher Iain, Johnston, Rosalynd, Chevassut, Timothy J, Pepper, Chris, Pepper, Andrea G S and others, (2021) TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target. Blood. pp. 1-32. ISSN 0006-4971

Oliver Metzig, Marie, Tang, Ying, Mitchell, Simon, Taylor, Brooks, Foreman, Robert, Wollman, Roy and Hoffmann, Alexander (2020) An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions. Molecular Systems Biology, 16 (12). e9677 1-17. ISSN 1744-4292

Latifi, Shahrzad, Mitchell, Simon, Habibey, Rouhollah, Hosseini, Fouzhan, Donzis, Elissa, Estrada-Sánchez, Ana María, Nejad, H Rezaei, Levine, Michael, Golshani, Peyman and Carmichael, S Thomas (2020) Neuronal network topology indicates distinct recovery processes after stroke. Cerebral Cortex. ISSN 1047-3211

Ngo, Kim A, Kishimoto, Kensei, Davis-Turak, Jeremy, Pimplaskar, Aditya Pimplaskar, Cheng, Zhang, Spreafico, Roberto, Chen, Emily Y, Tam, Amy, Ghosh, Gourisankar, Mitchell, Simon and Hoffman, Alexander (2020) Dissecting the regulatory strategies of NF-kB RelA target genes in the inflammatory response reveals differential transactivation logics. Cell Reports, 30 (8). pp. 2758-2775. ISSN 2211-1247

Mitchell, Simon, Mercado, Ellen L, Adelaja, Adewunmi, Ho, Jessica Q, Cheng, Quen J, Ghosh, Gourisankar and Hoffmann, Alexander (2019) An NFkB activity calculator to delineate signaling crosstalk: type I and II interferons enhance NFkB via distinct mechanisms. Frontiers in Immunology, 10 (1425). pp. 1-16. ISSN 1664-3224

Mitchell, Simon and Hoffmann, Alexander (2019) Substrate complex competition – a regulatory motif that allows NFkB RelA to license but not amplify NFkB RelB. Proceedings of the National Academy of Sciences, 116 (21). pp. 10592-10597. ISSN 1091-6490

Roy, Koushik, Mitchell, Simon, Liu, Yi, Ohta, Sho, Lin, Yu-sheng, Metzig, Marie Oliver, Nutt, Stephen L. and Hoffmann, Alexander (2019) A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation. Immunity, 50 (3). 616-628.e6. ISSN 1074-7613

Yeom, Kyu-Hyeon, Mitchell, Simon, Linares, Anthony J, Zheng, Sika, Lin, Chia-Ho, Wang, Xiao-Jun, Hoffmann, Alexander and Black, Douglas L (2018) Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proceedings of the National Academy of Sciences, 115 (47). E11061-E11070. ISSN 0027-8424

Mitchell, Simon and Hoffmann, Alexander (2018) Identifying noise sources governing cell-to-cell variability. Current Opinion in Systems Biology, 8. pp. 39-45. ISSN 2452-3100

Mitchell, Simon, Roy, Koushik, Zangle, Thomas A and Hoffmann, Alexander (2018) Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proceedings of the National Academy of Sciences, 115 (12). E2888-E2897. ISSN 0027-8424

Mitchell, Simon, Vargas, Jesse and Hoffmann, Alexander (2016) Signaling via the NFκB system. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 8 (3). pp. 227-241. ISSN 1939-5094

Spreafico, Roberto, Mitchell, Simon and Hoffmann, Alexander (2015) Training the 21st century immunologist. Trends in Immunology, 36 (5). pp. 283-285. ISSN 1471-4906

Mitchell, Simon and Mendes, Pedro (2013) A computational model of liver iron metabolism. PLoS Computational Biology, 9 (11). e1003299 1-14. ISSN 1553-7358

Conference or Workshop Item

Jayawant, Eleanor Sophie, Pepper, Andrea, Pepper, Christopher and Mitchell, Simon (2022) P1266: Flow cytometry combined with systems biology enables rational targeting of NFKB in DLBCL. In: EHA2022 Congress, June 15-17, 2022, Vienna, Austia.