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Alexieva, D, Long, Y, Sarkar, R, Dhayan, H, Bruet, E, Winston, R, Vorechovsky, I, Castellano, L and Dibb, N J (2022) Background splicing as a predictor of aberrant splicing in genetic disease. RNA Biology, 19 (1). pp. 256-265. ISSN 1547-6286
Chrysostomou, Stelios, Roy, Rajat, Prischi, Filippo, Thamlikitkul, Lucksamon, Chapman, Kathryn L, Mufti, Uwais, Peach, Robert, Ding, Laifeng, Hancock, David, Moore, Christopher, Molina-Arcas, Miriam, Mauri, Francesco, Pinato, David J, Castellano, Leandro, Giamas, Georgios and others, (2021) Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. Science Translational Medicine, 13 (602). ISSN 1946-6234
Zagorac, Sladjana, de Giorgio, Alex, Dabrowska, Aleksandra, Kalisz, Mark, Casas-Vila, Nuria, Cathcart, Paul, Yiu, Angela, Ottaviani, Silvia, Degani, Neta, Lombardo, Ylenia, Tweedie, Alistair, Nissan, Tracy, Vance, Keith W, Ulitsky, Igor, Stebbing, Justin and Castellano, Leandro (2020) SCIRT lncRNA restrains tumorigenesis by opposing transcriptional programs of tumor-initiating cells. Cancer Research. ISSN 0008-5472
Malczewska, Anna, Frampton, Adam E, Mato Prado, Mireia, Ameri, Shima, Dabrowska, Aleksandra F, Zagorac, Sladjana, Clift, Ashley K, Kos-Kudła, Beata, Faiz, Omar, Stebbing, Justin, Castellano, Leandro and Frilling, Andrea (2019) Circulating MicroRNAs in Small Bowel Neuroendocrine Tumors – a potential tool for diagnosis and assessment of effectiveness of surgical resection. Annals of Surgery. ISSN 0003-4932
Ottaviani, Silvia, Stebbing, Justin, Frampton, Adam E, Zagorac, Sladjana, Krell, Jonathan, de Giorgio, Alexander, Trabulo, Sara M, Nguyen, Van T M, Magnani, Luca, Feng, Hugang, Giovannetti, Elisa, Funel, Nicola, Gress, Thomas, Jiao, Long, Lombardo, Ylenia, Lemoine, Nicholas R, Heeschen, Christopher and Castellano, Leandro (2018) TGF-ß induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nature Communications, 9 (1845). pp. 1-18. ISSN 2041-1723
Begum, S, Yiu, A, Stebbing, J and Castellano, L (2018) Novel tumour suppressive protein encoded by circular RNA, circ-SHPRH, in glioblastomas. Oncogene, 37. pp. 4055-4057. ISSN 1476-5594
Frampton, Adam E, Prado, Mireia Mato, López-Jiménez, Elena, Fajardo-Puerta, Ana Belen, Jawad, Zaynab A R, Lawton, Phillip, Giovannetti, Elisa, Habib, Nagy A, Castellano, Leandro, Stebbing, Justin, Krell, Jonathan and Jiao, Long R (2018) Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden. Oncotarget, 9 (27). pp. 19006-19013. ISSN 1949-2553
Macdougall, Claire E, Wood, Elizabeth G, Loschko, Jakob, Scagliotti, Valeria, Cassidy, Féaron C, Robinson, Mark E, Feldhahn, Niklas, Castellano, Leandro, Voisin, Mathieu-Benoit, Marelli-Berg, Federica, Gaston-Massuet, Carles, Charalambous, Marika and Longhi, M Paula (2018) Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets. Cell Metabolism, 27 (3). 588-601.e4. ISSN 1550-4131
Harrod, A, Fulton, J, Nguyen, V T M, Periyasamy, M, Ramos-Garcia, L, Lai, C-F, Metodieva, G, de Giorgio, A, Williams, R L, Santos, D B, Gomez, P J, Lin, M-L, Metodiev, M V, Stebbing, J, Castellano, L, Magnani, L, Coombes, R C, Buluwela, L and Ali, S (2017) Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene, 36 (16). pp. 2286-2296. ISSN 1476-5594
Boulianne, Bryant, Robinson, Mark E, May, Philippa C, Castellano, Leandro, Blighe, Kevin, Thomas, Jennifer, Reid, Alistair, Müschen, Markus, Apperley, Jane F, Stebbing, Justin and Feldhahn, Niklas (2017) Lineage-specific genes are prominent DNA damage hotspots during leukemic transformation of B cell precursors. Cell Reports, 18 (7). pp. 1687-1698. ISSN 2211-1247
Castellano, Leandro, Dabrowska, Aleksandra, Pellegrino, Loredana, Ottaviani, Silvia, Cathcart, Paul, Frampton, Adam E, Krell, Jonathan and Stebbing, Justin (2017) Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR. Nucleic Acids Research, 45 (8). pp. 4401-4412. ISSN 1362-4962
Miller, Helen C, Frampton, Adam E, Malczewska, Anna, Ottaviani, Silvia, Stronach, Euan A, Flora, Rashpal, Kaemmerer, Daniel, Schwach, Gert, Pfragner, Roswitha, Faiz, Omar, Kos-Kudła, Beata, Hanna, George B, Stebbing, Justin, Castellano, Leandro and Frilling, Andrea (2016) MicroRNAs associated with small bowel neuroendocrine tumours and their metastases. Endocrine-related cancer, 23 (9). pp. 711-726. ISSN 1479-6821
Pardo, Olivier E, Castellano, Leandro, Munro, Catriona E, Hu, Yili, Mauri, Francesco, Krell, Jonathan, Lara, Romain, Pinho, Filipa G, Choudhury, Thameenah, Frampton, Adam E, Pellegrino, Loredana, Pshezhetskiy, Dmitry, Wang, Yulan, Waxman, Jonathan, Seckl, Michael J and Stebbing, Justin (2016) miR-515-5p controls cancer cell migration through MARK4 regulation. EMBO reports, 17 (4). pp. 570-584. ISSN 1469-3178
Jacob, Jimmy, Favicchio, Rosa, Karimian, Negin, Mehrabi, Maryam, Harding, Victoria, Castellano, Leandro, Stebbing, Justin and Giamas, Georgios (2016) LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5. Cancer Letters, 372 (1). pp. 137-146. ISSN 0304-3835
Krell, Jonathan, Stebbing, Justin, Carissimi, Claudia, Dabrowska, Aleksandra F, de Giorgio, Alexander, Frampton, Adam E, Harding, Victoria, Fulci, Valerio, Macino, Giuseppe, Colombo, Teresa and Castellano, Leandro (2016) TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network. Genome Research, 26 (3). pp. 331-341. ISSN 1549-5469
Nguyen, Van T M, Barozzi, Iros, Faronato, Monica, Lombardo, Ylenia, Steel, Jennifer H, Patel, Naina, Darbre, Philippa, Castellano, Leandro, Győrffy, Balázs, Woodley, Laura, Meira, Alba, Patten, Darren K, Vircillo, Valentina, Periyasamy, Manikandan, Ali, Simak, Frige, Gianmaria, Minucci, Saverio, Coombes, R Charles and Magnani, Luca (2015) Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature Communications, 6 (10044). ISSN 2041-1723
Roca-Alonso, L, Castellano, L, Mills, A, Dabrowska, A F, Sikkel, M B, Pellegrino, L, Jacob, J, Frampton, A E, Krell, J, Coombes, R C, Harding, S E, Lyon, A R and Stebbing, J (2015) Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis. Cell Death & Disease, 6. e1754. ISSN 2041-4889
Castellano, Leandro, Rizzi, Ermanno, Krell, Jonathan, Di Cristina, Manlio, Galizi, Roberto, Mori, Ayako, Tam, Janis, De Bellis, Gianluca, Stebbing, Justin, Crisanti, Andrea and Nolan, Tony (2015) The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNA. BMC Genomics, 16. p. 100.
Tan, Geok Chin, Chan, Elcie, Molnar, Attila, Sarkar, Rupa, Alexieva, Diana, Isa, Ihsan Mad, Robinson, Sophie, Zhang, Shuchen, Ellis, Peter, Langford, Cordelia F, Guillot, Pascale V, Chandrashekran, Anil, Fisk, Nick M, Castellano, Leandro, Meister, Gunter, Winston, Robert M, Cui, Wei, Baulcombe, David and Dibb, Nick J (2014) 5' isomiR variation is of functional and evolutionary importance. Nucleic Acids Research, 42 (14). pp. 9424-9435. ISSN 1362-4962
Krell, Jonathan, Frampton, Adam E, Mirnezami, Reza, Harding, Victoria, De Giorgio, Alex, Roca Alonso, Laura, Cohen, Patrizia, Ottaviani, Silvia, Colombo, Teresa, Jacob, Jimmy, Pellegrino, Loredana, Buchanan, Gordon, Stebbing, Justin and Castellano, Leandro (2014) Growth arrest-specific transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer. PLoS ONE, 9 (6). e98561. ISSN 1932-6203
Frampton, Adam E, Castellano, Leandro, Colombo, Teresa, Giovannetti, Elisa, Krell, Jonathan, Jacob, Jimmy, Pellegrino, Loredana, Roca-Alonso, Laura, Funel, Niccola, Gall, Tamara M H, De Giorgio, Alexander, Pinho, Filipa G, Fulci, Valerio, Britton, David J, Ahmad, Raida, Habib, Nagy A, Coombes, R Charles, Harding, Victoria, Knösel, Thomas, Stebbing, Justin and Jiao, Long R (2014) MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression. Gastroenterology, 146 (1). 268-277.e18. ISSN 0016-5085
Pinho, Filipa G, Frampton, Adam E, Nunes, Joao, Krell, Jonathan, Alshaker, Heba, Jacob, Jimmy, Pellegrino, Loredana, Roca-Alonso, Laura, de Giorgio, Alexander, Harding, Victoria, Waxman, Jonathan, Stebbing, Justin, Pchejetski, Dmitry and Castellano, Leandro (2013) Downregulation of microRNA-515-5p by the estrogen receptor modulates sphingosine kinase 1 and breast cancer cell proliferation. Cancer Research, 73 (19). pp. 5936-5948. ISSN 0008-5472
Pellegrino, Loredana, Stebbing, Justin, Braga, Vania M, Frampton, Adam E, Jacob, Jimmy, Buluwela, Lakjaya, Jiao, Long R, Periyasamy, Manikandan, Madsen, Chris D, Caley, Matthew P, Ottaviani, Silvia, Roca-Alonso, Laura, El-Bahrawy, Mona, Coombes, R Charles, Krell, Jonathan and Castellano, Leandro (2013) miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts. Nucleic Acids Research, 41 (10). pp. 5400-5412. ISSN 1362-4962
Castellano, Leandro and Stebbing, Justin (2013) Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues. Nucleic Acids Research, 41 (5). pp. 3339-3351. ISSN 0305-1048
Krell, Jonathan, Frampton, Adam E, Jacob, Jimmy, Pellegrino, Loredana, Roca-Alonso, Laura, Zeloof, Daniel, Alifrangis, Costi, Lewis, Jacqueline S, Jiao, Long R, Stebbing, Justin and Castellano, Leandro (2012) The clinico-pathologic role of microRNAs miR-9 and miR-151-5p in breast cancer metastasis. Molecular Diagnosis & Therapy, 16 (3). pp. 167-172. ISSN 1179-2000
Jiao, Long R, Frampton, Adam E, Jacob, Jimmy, Pellegrino, Loredana, Krell, Jonathan, Giamas, Georgios, Tsim, Nicole, Vlavianos, Panagiotis, Cohen, Patrizia, Ahmad, Raida, Keller, Andreas, Habib, Nagy A, Stebbing, Justin and Castellano, Leandro (2012) MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors. PLoS ONE, 7 (2). e32068. ISSN 1932-6203
Giamas, Georgios, Filipović, Aleksandra, Jacob, Jimmy, Messier, Walter, Zhang, Hua, Yang, Dongyun, Zhang, Wu, Shifa, Belul Assefa, Photiou, Andrew, Tralau-Stewart, Cathy, Castellano, Leandro, Green, Andrew R, Coombes, R Charles, Ellis, Ian O, Ali, Simak, Lenz, Heinz-Josef and Stebbing, Justin (2011) Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nature Medicine, 17 (6). pp. 715-719. ISSN 1546-170X
Castellano, Leandro, Giamas, Georgios, Jacob, Jimmy, Coombes, R Charles, Lucchesi, Walter, Thiruchelvam, Paul, Barton, Geraint, Jiao, Long R, Wait, Robin, Waxman, Jonathan, Hannon, Gregory J and Stebbing, Justin (2009) The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response. Proceedings of the National Academy of Sciences, 106 (37). pp. 15732-15737. ISSN 1091-6490
Giamas, Georgios, Castellano, Leandro, Feng, Qin, Knippschild, Uwe, Jacob, Jimmy, Thomas, Ross S, Coombes, R Charles, Smith, Carolyn L, Jiao, Long R and Stebbing, Justin (2009) CK1δ modulates the transcriptional activity of ERα via AIB1 in an estrogen-dependent manner and regulates ERα-AIB1 interactions. Nucleic Acids Research, 37 (9). pp. 3110-3123. ISSN 0305-1048
Apostolopoulos, Christos, Castellano, Leandro, Stebbing, Justin and Giamas, Georgios (2008) Bendamustine as a model for the activity of alkylating agents. Future Oncology, 4 (3). pp. 323-332. ISSN 1479-6694
Fulci, Valerio, Chiaretti, Sabina, Goldoni, Marina, Azzalin, Gianluca, Carucci, Nicoletta, Tavolaro, Simona, Castellano, Leandro, Magrelli, Armando, Citarella, Franca, Messina, Monica, Maggio, Roberta, Peragine, Nadia, Santangelo, Simona, Mauro, Francesca Romana, Landgraf, Pablo, Tuschl, Thomas, Weir, David B, Chien, Minchen, Russo, James J, Ju, Jingyue, Sheridan, Robert, Sander, Chris, Zavolan, Mihaela, Guarini, Anna, Foà, Robin and Macino, Giuseppe (2007) Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood, 109 (11). pp. 4944-4951. ISSN 0006-4971
Conference Proceedings
Castellano, L, Waxman, J, Giamas, G, Apostolopous, C and Stebbing, J (2008) The identification of new tumour suppressor micromas epigenetically silenced in drug resistant cancer cells. 20th Meeting of the European Association for Cancer Research, Lyon, France, 5-8 July 2008. Published in: European Journal of Cancer Supplements. 6 (9) 95-95. Elsevier ISSN 1359-6349
Giamas, G, Ali, S, Apostolopoulos, C, Castellano, L, Coombes, C and Stebbing, J (2008) The identification of new signaling pathways involved in estrogen receptor-alpha (ER alpha) transcriptional activity. Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference, Athens, Greece, June 28 - July 03, 2008. Published in: FEBS JOURNAL. 275 137-137. ISSN 1742-464X