Soares, Patricia, Fidler, Katy, Felton, Jessie, Jones, Christina J, Tavendale, Roger, Hövels, Anke, Bremner, Stephen, Palmer, Colin N A and Mukhopadhyay, Somnath (2021) An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing. Clin Exp Allergy. pp. 1-4. ISSN 0954-7894

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Abstract

The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Primary Care and Public Health
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	14 Jun 2021 07:58
Last Modified:	14 Jun 2021 08:00
URI:	http://sro.sussex.ac.uk/id/eprint/99760

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