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An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

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posted on 2023-06-10, 00:05 authored by Patricia Soares, Katy FidlerKaty Fidler, Jessie Felton, Christina J Jones, Roger Tavendale, Anke Hövels, Stephen BremnerStephen Bremner, Colin N A Palmer, Somnath MukhopadhyaySomnath Mukhopadhyay
The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

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Publication status

  • Published

File Version

  • Published version

Journal

Clin Exp Allergy

ISSN

0954-7894

Publisher

Wiley

Page range

1-4

Event location

England

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-06-14

First Open Access (FOA) Date

2021-06-14

First Compliant Deposit (FCD) Date

2021-06-11

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