Comparison of cerebellar grey matter alterations in bipolar and cerebellar patients: evidence from voxel-based analysis

Lupo, Michela, Olivito, Giusy, Gragnani, Andrea, Saettoni, Marco, Siciliano, Libero, Pancheri, Corinna, Panfili, Matteo, Bozzali, Marco, Delle Chiaie, Roberto and Leggio, Maria (2021) Comparison of cerebellar grey matter alterations in bipolar and cerebellar patients: evidence from voxel-based analysis. International Journal of Molecular Sciences, 22 (7). a2511 1-12. ISSN 1661-6596

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Abstract

The aim of this study was to compare the patterns of cerebellar alterations associated with bipolar disease with those induced by the presence of cerebellar neurodegenerative pathologies to clarify the potential cerebellar contribution to bipolar affective disturbance. Twenty-nine patients affected by bipolar disorder, 32 subjects affected by cerebellar neurodegenerative pathologies, and 37 age-matched healthy subjects underwent a 3T MRI protocol. A voxel-based morphometry analysis was used to show similarities and differences in cerebellar grey matter (GM) loss between the groups. We found a pattern of GM cerebellar alterations in both bipolar and cerebellar groups that involved the anterior and posterior cerebellar regions (p = 0.05). The direct comparison between bipolar and cerebellar patients demonstrated a significant difference in GM loss in cerebellar neurodegenerative patients in the bilateral anterior and posterior motor cerebellar regions, such as lobules I−IV, V, VI, VIIIa, VIIIb, IX, VIIb and vermis VI, while a pattern of overlapping GM loss was evident in right lobule V, right crus I and bilateral crus II. Our findings showed, for the first time, common and different alteration patterns of specific cerebellar lobules in bipolar and neurodegenerative cerebellar patients, which allowed us to hypothesize a cerebellar role in the cognitive and mood dysregulation symptoms that characterize bipolar disorder.

Item Type: Article
Keywords: bipolar disorder, cerebellar atrophy, cerebellar grey matter volume, voxel-based morphometry, Adult, Atrophy, Bipolar Disorder, Cerebellar Diseases, Cerebellum, Female, Gray Matter, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurodegenerative Diseases
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 04 Jun 2021 10:45
Last Modified: 04 Jun 2021 10:45
URI: http://sro.sussex.ac.uk/id/eprint/99634

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