ijms-22-03511-v2.pdf (5.92 MB)
Comparison of cerebellar grey matter alterations in bipolar and cerebellar patients: evidence from voxel-based analysis
journal contribution
posted on 2023-06-10, 00:02 authored by Michela Lupo, Giusy Olivito, Andrea Gragnani, Marco Saettoni, Libero Siciliano, Corinna Pancheri, Matteo Panfili, Marco Bozzali, Roberto Delle Chiaie, Maria LeggioThe aim of this study was to compare the patterns of cerebellar alterations associated with bipolar disease with those induced by the presence of cerebellar neurodegenerative pathologies to clarify the potential cerebellar contribution to bipolar affective disturbance. Twenty-nine patients affected by bipolar disorder, 32 subjects affected by cerebellar neurodegenerative pathologies, and 37 age-matched healthy subjects underwent a 3T MRI protocol. A voxel-based morphometry analysis was used to show similarities and differences in cerebellar grey matter (GM) loss between the groups. We found a pattern of GM cerebellar alterations in both bipolar and cerebellar groups that involved the anterior and posterior cerebellar regions (p = 0.05). The direct comparison between bipolar and cerebellar patients demonstrated a significant difference in GM loss in cerebellar neurodegenerative patients in the bilateral anterior and posterior motor cerebellar regions, such as lobules I-IV, V, VI, VIIIa, VIIIb, IX, VIIb and vermis VI, while a pattern of overlapping GM loss was evident in right lobule V, right crus I and bilateral crus II. Our findings showed, for the first time, common and different alteration patterns of specific cerebellar lobules in bipolar and neurodegenerative cerebellar patients, which allowed us to hypothesize a cerebellar role in the cognitive and mood dysregulation symptoms that characterize bipolar disorder.
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- Published
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- Published version
Journal
International Journal of Molecular SciencesISSN
1661-6596Publisher
MDPIExternal DOI
Issue
7Volume
22Page range
1-12Article number
a2511Event location
SwitzerlandDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-06-04First Open Access (FOA) Date
2021-06-04First Compliant Deposit (FCD) Date
2021-06-04Usage metrics
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