The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences? A systematic review

Ranjbar, Maryam, Salehi, Rasoul, Haghjooy Javanmard, Shaghayegh, Rafiee, Laleh, Faraji, Habibollah, jafarpor, Sima, Ferns, Gordon A, Ghayour-Mobarhan, Majid, Manian, Mostafa and Nedaeinia, Reza (2021) The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences? A systematic review. Cancer Cell International, 21. a194 1-24. ISSN 1475-2867

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth attributable cause of mortality and morbidity due to cancer. An emerging factor contributing to CRC is the gut microbiota and the cellular changes associated with it. Further insights on this may help in the prevention, diagnosis and new therapeutic approaches to colorectal cancer. In most cases of CRC, genetic factors appear to contribute less to its aetiology than environmental and epigenetic factors; therefore, it may be important to investigate these environmental factors, their effects, and the mechanisms that may contribute to this cancer. The gut microbiota has recently been highlighted as a potential risk factor that may affect the structural components of the tumor microenvironment, as well as free radical and enzymatic metabolites directly, or indirectly. Many studies have reported changes in the gut microbiota of patients with colorectal cancer. What is controversial is whether the cancer is the cause or consequence of the change in the microbiota. There is strong evidence supporting both possibilities. The presence of Fusobacterium nucleatum in human colorectal specimens has been demonstrated by RNA-sequencing. F. nucleatum has been shown to express high levels of virulence factors such as FadA, Fap2 and MORN2 proteins. Our review of the published data suggest that F. nucleatum may be a prognostic biomarker of CRC risk, and hence raises the potential of antibiotic treatment of F. nucleatum for the prevention of CRC.

Item Type: Article
Keywords: Colorectal cancer, Dysbiosis signature, F. nucleatum, Gut microbiota
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 04 Jun 2021 09:44
Last Modified: 26 Nov 2021 13:28
URI: http://sro.sussex.ac.uk/id/eprint/99633

View download statistics for this item

📧 Request an update