The clinical application of Circulating tumor cells and DNAs as prognostic and predictive biomarkers in gastrointestinal cancer

Memarpour, Sara, Khalili-Tanha, Ghazaleh, Ghannad, Awa Alizadeh, Razavi, Masoud Sharifian, Joudi, Mona, Joodi, Marjan, Ferns, Gordon A, Hassanian, Seyed Mahdi, Khazaei, Majid and Avan, Amir (2021) The clinical application of Circulating tumor cells and DNAs as prognostic and predictive biomarkers in gastrointestinal cancer. Current Cancer Drug Targets, 21 (8). pp. 676-688. ISSN 1568-0096

[img] PDF - Accepted Version
Download (458kB)
[img] Image (JPEG) - Supplemental Material
Download (1MB)

Abstract

Gastrointestinal (GI) cancer is one of the most common cancers globally. Genetic and epigenetic mechanisms are involved in its pathogenesis. The conventional methods for diagnosis and screening for GI cancers are often invasive and have other limitations. In the era of personalized medicine, a novel non-invasive approach called liquid biopsy has been introduced for the detection and management of GI cancers, which focuses on the analysis of circulating tumor cells (CTCs) and circulating cell-free tumor DNA (ctDNA). Several studies have shown that this new approach allows for an improved understanding of GI tumor biology and will lead to an improvement in clinical management. The aim of the current review is to explore the clinical applications of CTCs and ctDNA in patients with GI cancer.
Key words: Gastrointestinal cancer; Liquid biopsy; CTCs; ctDNA; biomarkers; tumor biology

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 04 Jun 2021 07:11
Last Modified: 21 Mar 2022 16:30
URI: http://sro.sussex.ac.uk/id/eprint/99594

View download statistics for this item

📧 Request an update