Deep brain stimulation fine-tuning in Parkinson’s disease: short pulse width effect on speech

Fabbri, Margherita, Natale, Federico, Artusi, Carlo Alberto, Romagnolo, Alberto, Bozzali, Marco, Giulietti, Giovanni, Guimaraes, Isabel, Rizzone, Mario Giorgio, Accornero, Anna, Lopiano, Leonardo and Zibetti, Maurizio (2021) Deep brain stimulation fine-tuning in Parkinson’s disease: short pulse width effect on speech. Parkinsonism & Related Disorders, 87. pp. 130-134. ISSN 1353-8020

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Abstract

Background
subthalamic nucleus deep brain stimulation (STN-DBS) may have a detrimental effect on speech in Parkinson's disease (PD) patients and new stimulation technologies may help in addressing this issue.

Objective
to evaluate the STN-DBS acute effect of 30 μs pulse width (30PW) versus conventional 60 μs PW (60PW) on speech and identify the core features of voice modified by 30PW.

Methods
seven STN-DBS treated PD patients participated into a pilot cross-sectional study. Motor and speech performances were tested by means of both automatic analysis and blinded clinical evaluations in four stimulation conditions: 30PW and 60PW both at the usual amplitude and at an amplitude just below the threshold for stimulation-related side effects.

Results
at the threshold amplitude, 30PW stimulation improved speech intelligibility for both words (p = 0.02) and sentences (p = 0.04), without worsening motor performance. A lower but not statistically significant voice variability and instability and percentage of stuttering disfluencies was also observed. The beneficial effect of 30PW detected by automatic analysis, was confirmed by patients’ perception.

Conclusions
STN-DBS treated patients experiencing low speech intelligibility may benefit from a 30PW stimulation trial at a higher amplitude. Deep characterization of PD speech profiles may help in a better application of recent DBS hardware advances.

Item Type: Article
Keywords: Parkinson's Disease, deep brain stimulation, short-pulse width, dysarthria
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 18 May 2021 07:59
Last Modified: 19 May 2022 01:00
URI: http://sro.sussex.ac.uk/id/eprint/99216

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