Deep%20brain%20stimulation%20fine%20tuning%20in%20Parkinson%27s%20disease%20-%20short%20pulse%20width%20effect%20on%20speech.pdf (785.66 kB)
Deep brain stimulation fine-tuning in Parkinson’s disease: short pulse width effect on speech
Version 2 2023-06-20, 14:17
Version 1 2023-06-20, 14:12
journal contribution
posted on 2023-06-20, 14:17 authored by Margherita Fabbri, Federico Natale, Carlo Alberto Artusi, Alberto Romagnolo, Marco Bozzali, Giovanni Giulietti, Isabel Guimaraes, Mario Giorgio Rizzone, Anna Accornero, Leonardo Lopiano, Maurizio ZibettiBackground subthalamic nucleus deep brain stimulation (STN-DBS) may have a detrimental effect on speech in Parkinson's disease (PD) patients and new stimulation technologies may help in addressing this issue. Objective to evaluate the STN-DBS acute effect of 30 µs pulse width (30PW) versus conventional 60 µs PW (60PW) on speech and identify the core features of voice modified by 30PW. Methods seven STN-DBS treated PD patients participated into a pilot cross-sectional study. Motor and speech performances were tested by means of both automatic analysis and blinded clinical evaluations in four stimulation conditions: 30PW and 60PW both at the usual amplitude and at an amplitude just below the threshold for stimulation-related side effects. Results at the threshold amplitude, 30PW stimulation improved speech intelligibility for both words (p = 0.02) and sentences (p = 0.04), without worsening motor performance. A lower but not statistically significant voice variability and instability and percentage of stuttering disfluencies was also observed. The beneficial effect of 30PW detected by automatic analysis, was confirmed by patients’ perception. Conclusions STN-DBS treated patients experiencing low speech intelligibility may benefit from a 30PW stimulation trial at a higher amplitude. Deep characterization of PD speech profiles may help in a better application of recent DBS hardware advances.
History
Publication status
- Published
File Version
- Accepted version
Journal
Parkinsonism & Related DisordersISSN
1353-8020Publisher
ElsevierExternal DOI
Volume
87Page range
130-134Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-05-18First Open Access (FOA) Date
2022-05-19First Compliant Deposit (FCD) Date
2021-05-17Usage metrics
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