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The effects of zinc sulfate supplementation on serum copeptin, c-reactive protein and metabolic markers in zinc-deficient diabetic patients on hemodialysis: a randomized, double-blind, placebo-controlled trial
journal contribution
posted on 2023-06-09, 23:52 authored by Razieh Hosseini, Farzaneh Montazerifar, Elham Shahraki, Mansour Karajibani, Ali Mohammad Mokhtari, Ali Reza Dashipour, Gordon FernsGordon Ferns, Mohammad JalaliWe aimed to investigate the association between zinc (Zn) supplementation and serum levels of copeptin, high-sensitive C-reactive protein (hs-CRP), glycemic control, anthropometric parameters and renal function in Zn -deficient diabetic hemodialysis patients (DHPs). This randomized, double-blind, placebo-controlled trial (RCT) was conducted on 46 DHPs with Zn-deficiency. The Zn supplement group (n = 21) received a 220-mg/day Zn sulfate capsule (containing 50 mg Zn), and the control group (n = 25) received a placebo capsule (220 mg corn starch), for 8 weeks. Fasting, predialysis blood samples were taken at baseline and after 8 weeks to assess fasting blood glucose (FBG), serum insulin, copeptin, high-sensitive C-reactive protein (hs-CRP), blood urea nitrogen (BUN), creatinine (Cr) concentrations, and homoeostatic model assessment (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI). Compared to controls, serum copeptin (P < 0.001), hs-CRP (P < 0.001), BUN (P < 0.001), Cr (P < 0.001), Zn (P < 0.001), FBG (P < 0.001) levels, BMI (P < 0.001), and body weight (P < 0.001) were significantly affected following ZnSO4 supplementation for 8 weeks. In contrast, QUICKI (P = 0.57), HOMA-IR (P = 0.60), and serum insulin (P = 0.55) were not affected following Zn supplementation in comparison with patients receiving placebo. Zn sulfate supplementation appears to have favorable effects on serum copeptin and hs-CRP, FBG, and renal function in Zn-deficient DHPs. Iranian Registry of Clinical Trials Identifier: IRCT20190806044461N1
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- Published
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- Accepted version
Journal
Biological Trace Element ResearchISSN
0163-4984Publisher
SpringerExternal DOI
Department affiliated with
- Division of Medical Education Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-05-17First Open Access (FOA) Date
2022-03-04First Compliant Deposit (FCD) Date
2021-05-14Usage metrics
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