Fernández-Casañas, Maria and Chan, Kok-Lung (2018) The unresolved problem of DNA bridging. Genes, 9 (12). a623 1-16. ISSN 2073-4425
![]() |
PDF
- Published Version
Available under License Creative Commons Attribution. Download (2MB) |
Abstract
Accurate duplication and transmission of identical genetic information into offspring cells lies at the heart of a cell division cycle. During the last stage of cellular division, namely mitosis, the fully replicated DNA molecules are condensed into X-shaped chromosomes, followed by a chromosome separation process called sister chromatid disjunction. This process allows for the equal partition of genetic material into two newly born daughter cells. However, emerging evidence has shown that faithful chromosome segregation is challenged by the presence of persistent DNA intertwining structures generated during DNA replication and repair, which manifest as so-called ultra-fine DNA bridges (UFBs) during anaphase. Undoubtedly, failure to disentangle DNA linkages poses a severe threat to mitosis and genome integrity. This review will summarize the possible causes of DNA bridges, particularly sister DNA inter-linkage structures, in an attempt to explain how they may be processed and how they influence faithful chromosome segregation and the maintenance of genome stability.
Item Type: | Article |
---|---|
Keywords: | Bloom’s syndrome complex, PICH/ERCC6L, Ultra-fine DNA bridges, chromosome segregation, sister chromatid disjunction |
Schools and Departments: | School of Life Sciences > Sussex Centre for Genome Damage and Stability |
SWORD Depositor: | Mx Elements Account |
Depositing User: | Mx Elements Account |
Date Deposited: | 12 May 2021 09:41 |
Last Modified: | 18 Feb 2022 15:06 |
URI: | http://sro.sussex.ac.uk/id/eprint/99025 |
View download statistics for this item
📧 Request an updateProject Name | Sussex Project Number | Funder | Funder Ref |
---|---|---|---|
Elucidating the mechanisms of centromere protection and disjunction in genome stability maintenance | G2743 | WELLCOME TRUST | 104178/Z/14/A |
Molecular basis of inheritable DNA lesions on genome transformation | G1408 | WELLCOME TRUST | 104178/Z/14/Z |