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Olukoga, Tomisin, Fernández-Casañas, Maria and Chan, Kok-Lung (2019) Another string to the polo bow: a new mitotic role of PLK1 in centromere protection. Molecular and Cellular Oncology, 6 (6). a1658515 1-3. ISSN 2372-3556
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Official URL: https://doi.org/10.1080/23723556.2019.1658515
Abstract
Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity.
Item Type: | Article |
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Keywords: | BLM helicase, PICH translocase, PLK1, centromere dislocation, chromosome biorientation, ultra-fine DNA bridges |
Schools and Departments: | School of Life Sciences > Sussex Centre for Genome Damage and Stability |
SWORD Depositor: | Mx Elements Account |
Depositing User: | Mx Elements Account |
Date Deposited: | 12 May 2021 09:34 |
Last Modified: | 18 Feb 2022 15:08 |
URI: | http://sro.sussex.ac.uk/id/eprint/99023 |
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📧 Request an updateFunder and Project Information
Project Name | Sussex Project Number | Funder | Funder Ref |
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Elucidating the mechanisms of centromere protection and disjunction in genome stability maintenance | G2743 | WELLCOME TRUST | 104178/Z/14/A |
Molecular basis of inheritable DNA lesions on genome transformation | G1408 | WELLCOME TRUST | 104178/Z/14/Z |