Another string to the polo bow: a new mitotic role of PLK1 in centromere protection

Olukoga, Tomisin, Fernández-Casañas, Maria and Chan, Kok-Lung (2019) Another string to the polo bow: a new mitotic role of PLK1 in centromere protection. Molecular and Cellular Oncology, 6 (6). a1658515 1-3. ISSN 2372-3556

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Abstract

Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity.

Item Type: Article
Keywords: BLM helicase, PICH translocase, PLK1, centromere dislocation, chromosome biorientation, ultra-fine DNA bridges
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 12 May 2021 09:34
Last Modified: 18 Feb 2022 15:08
URI: http://sro.sussex.ac.uk/id/eprint/99023

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Project NameSussex Project NumberFunderFunder Ref
Elucidating the mechanisms of centromere protection and disjunction in genome stability maintenanceG2743WELLCOME TRUST104178/Z/14/A
Molecular basis of inheritable DNA lesions on genome transformationG1408WELLCOME TRUST104178/Z/14/Z