Olukoga, Tomisin, Fernández-Casañas, Maria and Chan, Kok-Lung (2019) Another string to the polo bow: a new mitotic role of PLK1 in centromere protection. Molecular and Cellular Oncology, 6 (6). a1658515 1-3. ISSN 2372-3556

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Abstract

Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity.

Item Type:	Article
Keywords:	BLM helicase, PICH translocase, PLK1, centromere dislocation, chromosome biorientation, ultra-fine DNA bridges
Schools and Departments:	School of Life Sciences > Sussex Centre for Genome Damage and Stability
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	12 May 2021 09:34
Last Modified:	18 Feb 2022 15:08
URI:	http://sro.sussex.ac.uk/id/eprint/99023

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