University of Sussex
Browse
Another string to the polo bow a new mitotic role of PLK1 in centromere protection.pdf (1.14 MB)

Another string to the polo bow: a new mitotic role of PLK1 in centromere protection

Download (1.14 MB)
journal contribution
posted on 2023-06-09, 23:50 authored by Tomisin Olukoga, María Fernández CasanasMaría Fernández Casanas, Kok-Lung ChanKok-Lung Chan
Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity.

Funding

Molecular basis of inheritable DNA lesions on genome transformation; G1408; WELLCOME TRUST; 104178/Z/14/Z

Elucidating the mechanisms of centromere protection and disjunction in genome stability maintenance; G2743; WELLCOME TRUST; 104178/Z/14/A

History

Publication status

  • Published

File Version

  • Published version

Journal

Molecular and Cellular Oncology

ISSN

2372-3556

Publisher

Taylor & Francis

External DOI

Issue

6

Volume

6

Page range

1-3

Article number

a1658515

Event location

United States

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-05-12

First Open Access (FOA) Date

2021-05-12

First Compliant Deposit (FCD) Date

2021-05-12

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Keywords

    BLM helicasePICH translocasePLK1centromere dislocationchromosome biorientationultra-fine DNA bridges

    Licence

    CC BY 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC