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Redox regulation of immunity and the role of small molecular weight thiols

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journal contribution
posted on 2023-06-09, 23:49 authored by Pietro Ghezzi
It is thought that excessive production of reactive oxygen species (ROS) can be a causal component in many diseases, some of which have an inflammatory component. This led to an oversimplification whereby ROS are seen as inflammatory and antioxidants anti-inflammatory. This paper aims at reviewing some of the literature on thiols in host defense. The review will first summarize the mechanisms by which we survive infections by pathogens. Then we will consider how the redox field evolved from the concept of oxidative stress to that of redox regulation and how it intersects the field of innate immunity. A third section will analyze how an oversimplified oxidative stress theory of disease led to a hypothesis on the role of ROS and glutathione (GSH) in immunity, respectively as pro- and anti-inflammatory mediators. Finally, we will discuss some recent research and how to think out of the box of that oversimplification and link the role of thiols in redox regulation to the mechanisms by which we survive an infection outlined in the first section.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Redox Biology

ISSN

2213-2317

Publisher

Elsevier

Article number

a102001

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-05-10

First Open Access (FOA) Date

2021-05-10

First Compliant Deposit (FCD) Date

2021-05-08

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