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Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences

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Version 2 2023-06-12, 09:50
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posted on 2023-06-12, 09:50 authored by Kate ShawKate Shaw, L Bell, Katie Boyd, Dorieke Grijseels, D Clarke, Orla Bonnar, Hans CrombagHans Crombag, Catherine HallCatherine Hall
The hippocampus is essential for spatial and episodic memory but is damaged early in Alzheimer’s disease and is very sensitive to hypoxia. Understanding how it regulates its oxygen supply is therefore key for designing interventions to preserve its function. However, studies of neurovascular function in the hippocampus in vivo have been limited by its relative inaccessibility. Here we compared hippocampal and visual cortical neurovascular function in awake mice, using two photon imaging of individual neurons and vessels and measures of regional blood flow and haemoglobin oxygenation. We show that blood flow, blood oxygenation and neurovascular coupling were decreased in the hippocampus compared to neocortex, because of differences in both the vascular network and pericyte and endothelial cell function. Modelling oxygen diffusion indicates that these features of the hippocampal vasculature may restrict oxygen availability and could explain its sensitivity to damage during neurological conditions, including Alzheimer’s disease, where the brain’s energy supply is decreased.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Communications

ISSN

2041-1723

Publisher

Nature Research

Volume

12

Page range

1-16

Article number

a3190

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-04-29

First Open Access (FOA) Date

2021-06-01

First Compliant Deposit (FCD) Date

2021-04-28

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