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Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation

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journal contribution
posted on 2023-06-09, 23:36 authored by Stefano Caserta, Pietro Ghezzi
Many studies reported that redox enzymes, particularly thioredoxin and peroxiredoxin, can be released by cells and act as soluble mediators in immunity. Recently, it became clear that peroxiredoxins can be secreted via the exosome-release route, yet it remains unclear how this exactly happens and why. This review will first introduce briefly the possible redox states of protein cysteines and the role of redox enzymes in their regulation. We will then discuss the studies on the extracellular forms of some of these enzymes, their association with exosomes/extracellular vesicles and with exosome micro-RNAs (miRNAs)/mRNAs involved in oxidative processes, relevant in infection and inflammation.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Free Radical Biology and Medicine

ISSN

0891-5849

Publisher

Elsevier

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-04-14

First Open Access (FOA) Date

2022-04-14

First Compliant Deposit (FCD) Date

2021-04-14

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