Khoshghamat, Negar, Jafari, Niloufar, Moetamani-Ahmadi, Mehrdad, Khalili-Tanha, Ghazaleh, Khajavi rad, Mohammad-Hossein, Sahebdel, Saeed, Khalili-Tanha, Nima, Soleimanpour, Saman, Khazaei, Majid, Hassanian, Seyed Mahdi, Ferns, Gordon A and Avan, Amir (2021) Programmed cell death 1 as prognostic marker and therapeutic target in upper gastrointestinal cancers. Pathology - Research and Practice, 220. a153390 1-6. ISSN 0344-0338

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Abstract

Gastrointestinal (GIs) cancers are among the most common causes of cancer related death, and hence the importance for the identification of novel prognostic/predictive biomarkers for detection of patients at an early stage, and for using these to identify novel targeted therapies to improve the efficacy of existing chemotherapeutic regimens. Programmed cell death 1 has been reported as a potential target in several malignancies, and targeting agents are being developed, some already approved by FDA, such as: pembrolizumab, Atezolizumab, Nivolumab. Pembrolizumab that have been approved for the treatment of metastatic non-small cell lung cancer. Here we provide an overview of the mechanism of action PD-1/PD-L1, prognostic value and current progress in clinical trials using PD-1/PD-L1 inhibitors, and the resistant mechanisms at underlie the inhibitory effect of these agents in the treatment of gastrointestinal cancers.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	08 Apr 2021 07:08
Last Modified:	19 Feb 2022 02:00
URI:	http://sro.sussex.ac.uk/id/eprint/98162

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