Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: a meta-analysis

Schiele, Miriam A, Reif, Andreas, Lin, Jiaxi, Alpers, Georg W, Andersson, Evelyn, Andersson, Gerhard, Arolt, Volker, Bergström, Jan, Carlbring, Per, Eley, Thalia C, Esquivel, Gabriel, Furmark, Tomas, Gerlach, Alexander L, Hamm, Alfons and Lester, Kathryn J (2021) Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: a meta-analysis. European Neuropsychopharmacology, 44. pp. 105-120. ISSN 0924-977X

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Abstract

There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.

Item Type: Article
Keywords: CBT, Panic disorder, Serotonin transporter gene, Therapy outcome, Therapygenetics, Treatment response
Schools and Departments: School of Psychology > Psychology
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 26 Feb 2021 07:54
Last Modified: 21 Jan 2022 02:00
URI: http://sro.sussex.ac.uk/id/eprint/97415

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