LESTER_European_neuropsychopharmacology_Jan-2021.pdf (819.12 kB)
Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: a meta-analysis
journal contribution
posted on 2023-06-09, 23:10 authored by Miriam A Schiele, Andreas Reif, Jiaxi Lin, Georg W Alpers, Evelyn Andersson, Gerhard Andersson, Volker Arolt, Jan Bergström, Per Carlbring, Thalia C Eley, Gabriel Esquivel, Tomas Furmark, Alexander L Gerlach, Alfons Hamm, Kathryn LesterKathryn LesterThere is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.
History
Publication status
- Published
File Version
- Accepted version
Journal
European NeuropsychopharmacologyISSN
0924-977XPublisher
ElsevierExternal DOI
Volume
44Page range
105-120Event location
NetherlandsDepartment affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-02-26First Open Access (FOA) Date
2022-01-21First Compliant Deposit (FCD) Date
2021-02-25Usage metrics
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