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Molecular epidemiology of carbapenem-resistant acinetobacter baumannii from Khartoum State, Sudan

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Version 2 2023-06-12, 09:43
Version 1 2023-06-09, 23:02
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posted on 2023-06-12, 09:43 authored by Leena Al-HassanLeena Al-Hassan, Hana Elbadawi, Einas Osman, Sara Ali, Kamal Elhag, Daire Cantillon, Julia Wille, Harald Seifert, Paul G Higgins
Carbapenem resistant Acinetobacter baumannii (CRAb) is an important global pathogen contributing to increased morbidity and mortality in hospitalized patients, due to limited alternative treatment options. Nine international clonal (IC) lineages have been identified in many countries worldwide, however, data still lacks from some parts of the world, particularly in Africa. We hereby present the molecular epidemiology of MDR A. baumannii from four hospitals in Khartoum, Sudan, collected from 2017 to 2018. Forty-two isolates were whole-genome sequenced, and subsequent molecular epidemiology was determined by core genome MLST (cgMLST), and their resistomes identified. All isolates had an array of diverse antibiotic resistance mechanisms conferring resistance to multiple classes of antibiotics. We found a predominance (88%) of IC2 (with the intrinsic OXA-66 and acquired OXA-23), and some with NDM-1. IC2 isolates were sub-divided into 4 STs separated by 5 to 431 allelic differences, and with evidence of seven transmission clusters. Isolates belonging to IC1, IC5, and IC9 were also identified. These data illustrate that MDR IC2 A. baumannii are widely distributed in Khartoum hospitals and are in possession of multiple antibiotic resistance determinants.

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Publication status

  • Published

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  • Published version

Journal

Frontiers in Microbiology

ISSN

1664-302X

Publisher

Frontiers Media

Volume

12

Page range

1-9

Article number

a628736

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-02-12

First Open Access (FOA) Date

2021-03-02

First Compliant Deposit (FCD) Date

2021-02-12

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