The great pond snail (Lymnaea stagnalis) as a model of ageing and age-related memory impairment: an overview

Fodor, István, Svigruha, Réka, Kemenes, György, Kemenes, Ildikó and Pirger, Zsolt (2021) The great pond snail (Lymnaea stagnalis) as a model of ageing and age-related memory impairment: an overview. Journals of Gerontology, Series A, 76 (6). pp. 975-982. ISSN 1079-5006

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With the increase of life span, normal ageing and age-related memory decline are affecting an increasing number of people; however, many aspects of these processes are still not fully understood. Although vertebrate models have provided considerable insights into the molecular and electrophysiological changes associated with brain ageing, invertebrates, including the widely recognised molluscan model organism, the great pond snail (Lymnaea stagnalis) have proven to be extremely useful for studying mechanisms of ageing at the level of identified individual neurons and well-defined circuits. It’s numerically simpler nervous system, well-characterized life cycle and relatively long lifespan make it an ideal organism to study age-related changes in the nervous system. Here, we provide an overview of age-related studies on L. stagnalis and showcase this species as a contemporary choice for modelling the molecular, cellular, circuit, and behavioural mechanisms of ageing and age-related memory impairment.

Item Type: Article
Keywords: Lymnaea stagnalis, age-related memory impairment, ageing, mollusc, neuroscience
Schools and Departments: School of Life Sciences > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 05 Feb 2021 10:11
Last Modified: 25 Feb 2022 17:45

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Project NameSussex Project NumberFunderFunder Ref
G2208Updating of memories during memory consolidationBBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/P00766X/1