The challenges of chronic pain and fatigue

Eccles, Jessica A and Davies, Kevin A (2021) The challenges of chronic pain and fatigue. Clinical Medicine, 21 (1). pp. 19-27. ISSN 1470-2118

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In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the ‘clinical problem’. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 01 Feb 2021 09:06
Last Modified: 25 Feb 2022 17:47

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Project NameSussex Project NumberFunderFunder Ref
Fibroduck Foundation - Donation to continue PF5661G2725FIBRODUCK FOUNDATIONUnset
Investigating the effects of mild inflammation on brain function in ME/CFSG2485ACTION FOR MEUnset
Viscero-sensory processes and neural responses to inflammation: mechanisms of pain and fatigue in fibromyalgiaG1863ARTHRITIS RESEARCH UK21194