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Therapeutic potential of active components of saffron in post-surgical adhesion band formation

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posted on 2023-06-09, 22:53 authored by Mohammad-Hassan Arjmand, Milad Hashemzehi, Atena Soleimani, Fereshteh Asgharzadeh, Amir Avan, Saeedeh Mehraban, Maryam Fakhraei, Gordon FernsGordon Ferns, Mikhail Ryzhikov, Masoumeh Gharib, Roshanak Salari, Sayyed Hadi Sayyed Hoseinian, Mohammad Reza Parizadeh, Majid Khazaei, Seyed Mahdi Hassanian
Background Abdominal adhesions are common and often develop after abdominal surgery. There are currently no useful targeted pharmacotherapies for adhesive disease. Saffron and its active constituents, Crocin and Crocetin, are wildly used in traditional medicine for alleviating the severity of inflammatory or malignant disease. Purpose The aim of this study was to investigate the therapeutic potential of the pharmacological active component of saffron in attenuating the formation of post-operative adhesion bands using different administration methods in a murine model. Material method saffron extract (100 mg/kg), Crocin (100 mg/kg), and Crocetin (100 mg/kg) were administered intraperitoneally and by gavage in various groups of male Wistar rat post-surgery. Also three groups were first treated intra-peritoneally by saffron extract, Crocin, and Crocetin (100 mg/kg) for 10 days and then had surgery. At the end of the experiments, animals sacrificed for biological assessment. Result A hydro-alcoholic extract of saffron and crocin but not crocetin potently reduced the adhesion band frequency in treatment and pre-treatment groups in the mice given intra-peritoneal (i.p) injections. Following the saffron or crocin administration, histological evaluation and quantitative analysis represented less inflammatory cell infiltration and less collagen composition, compared to control group. Moreover, the oxidative stress was significantly reduced in treatment groups. Conclusion These findings suggest that a hydro-alcoholic extract of saffron or its active compound, crocin, is a potentially novel therapeutic strategy for the prevention of adhesions formation and might be used as beneficial anti-inflammatory or anti-fibrosis agents in clinical trials. Taxonomy Abdominal surgeries/post-surgical adhesions.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Traditional and Complementary Medicine

ISSN

2225-4110

Publisher

Committee on Chinese Medicine and Pharmacy

Issue

4

Volume

11

Page range

328-335

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-01-26

First Open Access (FOA) Date

2021-01-26

First Compliant Deposit (FCD) Date

2021-01-26

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